PMID- 26316612
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20210202
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 126
IP  - 9
DP  - 2015 Aug 27
TI  - Secretion of Wnts is dispensable for hematopoiesis.
PG  - 1051-2
LID - 10.1182/blood-2015-07-653402 [doi]
AB  - In this issue of Blood, Kabiri and coworkers report the hematopoietic deletion of 
      the endoplasmic reticulum-localized O-acyltransferase porcupine (PORCN), which is 
      necessary for acylation of Wnts in the endoplasmic reticulum, enabling their 
      secretion and binding to the frizzled receptors. Unexpectedly, the absence of 
      secreted Wnt factors does not have major effects on steady-state in vivo 
      hematopoiesis or on long-term repopulating activity of Wnt-deficient 
      hematopoietic stem cells.
FAU - Oostendorp, Robert A J
AU  - Oostendorp RA
AUID- ORCID: 0000-0002-4947-0412
AD  - KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
CON - Blood. 2015 Aug 27;126(9):1086-94. PMID: 26089398
MH  - Animals
MH  - *Hematopoiesis
MH  - Hematopoietic Stem Cells/*cytology
MH  - *Wnt Signaling Pathway
EDAT- 2015/09/01 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/08/29 06:00
PHST- 2015/08/29 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0006-4971(20)30969-1 [pii]
AID - 10.1182/blood-2015-07-653402 [doi]
PST - ppublish
SO  - Blood. 2015 Aug 27;126(9):1051-2. doi: 10.1182/blood-2015-07-653402.