PMID- 26316721
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150828
LR  - 20201001
IS  - 1177-889X (Print)
IS  - 1177-889X (Electronic)
IS  - 1177-889X (Linking)
VI  - 9
DP  - 2015
TI  - Detection and correlation analysis of serum cytokines in non-small-cell lung 
      cancer patients with bone and non-bone metastases.
PG  - 1165-9
LID - 10.2147/PPA.S86605 [doi]
AB  - OBJECTIVE: To detect and analyze 13 cytokines that may be related to bone 
      metastasis in the serum of non-small-cell lung cancer (NSCLC) patients with bone 
      metastases and NSCLC patients with non-bone metastases. PATIENTS AND METHODS: The 
      Luminex LiquiChip system was used to detect the concentration of 13 cytokines 
      that may be related to bone metastasis in the serum of 30 NSCLC patients with 
      bone metastases and 30 with non-bone metastases. RESULTS: The concentration of 
      insulin-like growth factor binding protein-3 (IGFBP-3) in the serum of NSCLC 
      patients with bone metastases was obviously higher than in non-bone metastasis 
      patients (P=0.014). The serum concentration of other cytokines showed no 
      significant difference (P>0.05) between the two groups. The concentration of 
      IGFBP-3 in the serum of the bone metastasis group was positively correlated to 
      VEGF concentration (r=0.804, P=0.009) and monocyte chemotactic protein 1 (MCP-1) 
      concentration (r=0.785, P=0.012), but had no correlation to other factors 
      (P>0.05). No correlation was found between serum concentrations of cytokines in 
      bone metastasis. Concentration of IGFBP-3 in the serum of bone metastasis 
      patients was positively correlated to the presence or absence of pain at 
      diagnosis (r=0.701, P=0.036) and performance status (PS) score (r=0.670, 
      P=0.048), and correlated with the number of bone metastases, sex, age, 
      pathological characteristics, T stage, and N stage (P>0.05). CONCLUSION: The 
      findings of this study suggest important clinical implications to detect the 
      concentration of IGFBP-3 in the serum of lung cancer patients so as to evaluate 
      the diagnosis and degree of bone metastasis. Concentration of IGFBP-3 in the 
      serum of bone metastasis patients was positively correlated to concentration of 
      VEGF and MCP-1, which may be highly relevant for the development of new 
      treatments for bone metastasis of lung cancer.
FAU - Sun, Yingjia
AU  - Sun Y
AD  - Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai, People's Republic of China.
FAU - Ai, Xinghao
AU  - Ai X
AD  - Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai, People's Republic of China.
FAU - Shen, Shengping
AU  - Shen S
AD  - Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai, People's Republic of China.
FAU - Gu, Linping
AU  - Gu L
AD  - Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai, People's Republic of China.
FAU - Lu, Shun
AU  - Lu S
AD  - Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20150812
PL  - New Zealand
TA  - Patient Prefer Adherence
JT  - Patient preference and adherence
JID - 101475748
PMC - PMC4542409
OTO - NOTNLM
OT  - cytokine
OT  - liquichip
OT  - metastatic lung cancer
EDAT- 2015/09/01 06:00
MHDA- 2015/09/01 06:01
PMCR- 2015/08/12
CRDT- 2015/08/29 06:00
PHST- 2015/08/29 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2015/09/01 06:01 [medline]
PHST- 2015/08/12 00:00 [pmc-release]
AID - ppa-9-1165 [pii]
AID - 10.2147/PPA.S86605 [doi]
PST - epublish
SO  - Patient Prefer Adherence. 2015 Aug 12;9:1165-9. doi: 10.2147/PPA.S86605. 
      eCollection 2015.