PMID- 26318886
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20220316
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 104
IP  - 5
DP  - 2015 Nov
TI  - Increased chromosome 16 disomy rates in human spermatozoa and recurrent 
      spontaneous abortions.
PG  - 1130-7.e1-10
LID - S0015-0282(15)01672-6 [pii]
LID - 10.1016/j.fertnstert.2015.07.1160 [doi]
AB  - OBJECTIVE: To investigate if unexplained recurrent spontaneous abortions (RSA) 
      are associated with increased rates of aneuploidy in spermatozoa of RSA partners 
      ("RSA-men"). DESIGN: Case-control study. SETTING: Academic research center. 
      PATIENT(S): Patients enrolled at the Hormone and Fertility Center and controls at 
      the Department of Urology (LMU-Munich). INTERVENTION(S): Sperm samples of 11 
      partners of unexplained RSA cases evaluated for elevated diploidy and disomy 
      levels of chromosomes 1-22, X, and Y by multicolor sperm fluorescence in situ 
      hybridization (FISH). MAIN OUTCOME MEASURE(S): Aneuploidy rates obtained in 
      RSA-men compared with controls from the literature and internally; an increase of 
      the aneuploidy rate was considered statistically significant, when it differed >/= 
      2 standard deviations from the mean baseline level in controls. RESULT(S): Our 
      sperm FISH data on RSA men showed increased disomy rates for at least three 
      chromosomes in more than 60% of patients but no statistically significant 
      increase of the overall mean sperm disomy or diploidy rate. In particular, 
      meiotic errors involving chromosome 16 contributed to increased sperm disomy in 
      more than 60% of our patients. CONCLUSION(S): These data suggest that among 
      paternal meiotic errors nondisjunction of chromosome 16 might have similar 
      relative influence on fetal aneuploidy compared with maternal chromosome 16 
      disomy.
CI  - Copyright (c) 2015. Published by Elsevier Inc.
FAU - Neusser, Michaela
AU  - Neusser M
AD  - Institute of Human Genetics, University Hospital, Ludwig Maximilian University of 
      Munich, Munich, Germany.
FAU - Rogenhofer, Nina
AU  - Rogenhofer N
AD  - Division of Gynecological Endocrinology and Reproductive Medicine, Department of 
      Obstetrics and Gynecology, Ludwig Maximilian University of Munich, Munich, 
      Germany.
FAU - Durl, Stephanie
AU  - Durl S
AD  - Institute of Human Genetics, University Hospital, Ludwig Maximilian University of 
      Munich, Munich, Germany.
FAU - Ochsenkuhn, Robert
AU  - Ochsenkuhn R
AD  - Fertility Center, Augsburg, Germany.
FAU - Trottmann, Matthias
AU  - Trottmann M
AD  - Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
FAU - Jurinovic, Vindi
AU  - Jurinovic V
AD  - Institute for Medical Informatics, Biometry and Epidemiology, Ludwig Maximilian 
      University of Munich, Munich, Germany.
FAU - Steinlein, Ortrud
AU  - Steinlein O
AD  - Institute of Human Genetics, University Hospital, Ludwig Maximilian University of 
      Munich, Munich, Germany.
FAU - von Schonfeldt, Viktoria
AU  - von Schonfeldt V
AD  - Division of Gynecological Endocrinology and Reproductive Medicine, Department of 
      Obstetrics and Gynecology, Ludwig Maximilian University of Munich, Munich, 
      Germany.
FAU - Muller, Stefan
AU  - Muller S
AD  - Institute of Human Genetics, University Hospital, Ludwig Maximilian University of 
      Munich, Munich, Germany. Electronic address: stefan.mueller@med.uni-muenchen.de.
FAU - Thaler, Christian J
AU  - Thaler CJ
AD  - Division of Gynecological Endocrinology and Reproductive Medicine, Department of 
      Obstetrics and Gynecology, Ludwig Maximilian University of Munich, Munich, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20150825
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Abortion, Habitual/diagnosis/*genetics
MH  - Adult
MH  - *Aneuploidy
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 16/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Meiosis
MH  - *Nondisjunction, Genetic
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Risk Factors
MH  - Spermatozoa/*pathology
OTO - NOTNLM
OT  - Aneuploidy
OT  - chromosome
OT  - miscarriage
OT  - recurrent pregnancy loss
OT  - spermatozoa
EDAT- 2015/09/01 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/08/31 06:00
PHST- 2014/09/29 00:00 [received]
PHST- 2015/07/25 00:00 [revised]
PHST- 2015/07/27 00:00 [accepted]
PHST- 2015/08/31 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - S0015-0282(15)01672-6 [pii]
AID - 10.1016/j.fertnstert.2015.07.1160 [doi]
PST - ppublish
SO  - Fertil Steril. 2015 Nov;104(5):1130-7.e1-10. doi: 
      10.1016/j.fertnstert.2015.07.1160. Epub 2015 Aug 25.