PMID- 26319355
OWN - NLM
STAT- MEDLINE
DCOM- 20160629
LR  - 20210109
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Print)
IS  - 2050-084X (Linking)
VI  - 4
DP  - 2015 Aug 29
TI  - Dissociable roles of the inferior longitudinal fasciculus and fornix in face and 
      place perception.
LID - 10.7554/eLife.07902 [doi]
LID - e07902
AB  - We tested a novel hypothesis, generated from representational accounts of medial 
      temporal lobe (MTL) function, that the major white matter tracts converging on 
      perirhinal cortex (PrC) and hippocampus (HC) would be differentially involved in 
      face and scene perception, respectively. Diffusion tensor imaging was applied in 
      healthy participants alongside an odd-one-out paradigm sensitive to PrC and HC 
      lesions in animals and humans. Microstructure of inferior longitudinal fasciculus 
      (ILF, connecting occipital and ventro-anterior temporal lobe, including PrC) and 
      fornix (the main HC input/output pathway) correlated with accuracy on odd-one-out 
      judgements involving faces and scenes, respectively. Similarly, blood oxygen 
      level-dependent (BOLD) response in PrC and HC, elicited during oddity judgements, 
      was correlated with face and scene oddity performance, respectively. We also 
      observed associations between ILF and fornix microstructure and 
      category-selective BOLD response in PrC and HC, respectively. These striking 
      three-way associations highlight functionally dissociable, structurally 
      instantiated MTL neurocognitive networks for complex face and scene perception.
FAU - Hodgetts, Carl J
AU  - Hodgetts CJ
AUID- ORCID: 0000-0002-0339-2447
AD  - School of Psychology, Cardiff University, Cardiff, Wales.
FAU - Postans, Mark
AU  - Postans M
AD  - School of Psychology, Cardiff University, Cardiff, Wales.
FAU - Shine, Jonathan P
AU  - Shine JP
AD  - School of Psychology, Cardiff University, Cardiff, Wales.
FAU - Jones, Derek K
AU  - Jones DK
AD  - School of Psychology, Cardiff University, Cardiff, Wales.
FAU - Lawrence, Andrew D
AU  - Lawrence AD
AUID- ORCID: 0000-0001-6705-2110
AD  - School of Psychology, Cardiff University, Cardiff, Wales.
FAU - Graham, Kim S
AU  - Graham KS
AUID- ORCID: 0000-0002-1512-7667
AD  - School of Psychology, Cardiff University, Cardiff, Wales.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 096646/WT_/Wellcome Trust/United Kingdom
GR  - BB/I007091/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - G1002149/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150829
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
SB  - IM
MH  - Brain Mapping/methods
MH  - Diffusion Tensor Imaging
MH  - *Facial Recognition
MH  - Female
MH  - Fornix, Brain/*physiology
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Neural Pathways/*physiology
MH  - *Space Perception
MH  - Temporal Lobe/*physiology
PMC - PMC4586481
OTO - NOTNLM
OT  - diffusion tensor imaging
OT  - human
OT  - medial temporal lobe
OT  - neuroscience
OT  - structure-function
OT  - tractography
OT  - visual perception
COIS- The authors declare that no competing interests exist.
EDAT- 2015/09/01 06:00
MHDA- 2016/06/30 06:00
PMCR- 2015/08/30
CRDT- 2015/08/31 06:00
PHST- 2015/04/02 00:00 [received]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/08/31 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/06/30 06:00 [medline]
PHST- 2015/08/30 00:00 [pmc-release]
AID - 07902 [pii]
AID - 10.7554/eLife.07902 [doi]
PST - epublish
SO  - Elife. 2015 Aug 29;4:e07902. doi: 10.7554/eLife.07902.