PMID- 26319381
OWN - NLM
STAT- MEDLINE
DCOM- 20151009
LR  - 20150831
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 39
IP  - 230
DP  - 2015 Aug
TI  - [Factors predisposing to the reprogramming of implantable 
      cardioverter-defibrillators and the causes of changes in pharmacotherapy in 
      patients with dilated cardiomyopathy for primary prevention of sudden cardiac 
      death].
PG  - 86-90
AB  - Ambulatory care of patients with implantable cardioverter-defibrillator (ICD) 
      involves regular follow-up visit, where a decision on reprogramming of the device 
      and modification of pharmacotherapy is made. AIM: The aim of the study was the 
      assessment of frequency and reasons of reprogramming and pharmacotherapy changes 
      in patients with dilated cardiomyopathy with an ICD implanted due to primary 
      prevention of sudden cardiac death (SCD). MATERIALS AND METHODS: The study 
      included 143 consecutive patients with an ICD implanted in 2010-2011. The 
      inclusion criteria were: left ventricle ejection fraction (LVEF)</=35%, New York 
      Heart Association (NYHA) Class>/=II, implantation due to primary prevention of SCD. 
      All ambulatory visits in outpatient department were investigated retrospectively. 
      The following variables were analyzed: age, gender, presence of coronary artery 
      disease (CAD) and atrial fibrillation (AF), LVEF, NYHA class, presence of 
      interventions, reprogramming and pharmacotherapy changes. RESULTS: The most 
      common changes in ICD parameters were modification of detection and therapy of 
      ventricular arrhythmias. Modification of pharmacotherapy were most often referred 
      to B-blocker and cardiac glycosides. Patients with AF had more often parameters 
      of bradycardia pacing changed (p=0,016). There was a significant correlation 
      between number of interventions and total number of reprogramming (r=0,3 p<0,05). 
      A negative correlation was found between LVEF and number of reprogramming of 
      detection of ventricular tachyarrhythmia (r=-0,18 p<0,05) and between LVEF and 
      number of interventions (r=-0,2, p<0,05). Patients with interventions and 
      patients AF had more pharmacotherapy changes (82 vs 29, p<0,001 and 59 vs 52, 
      p<0,01 respectively). A significant correlation was found between number of 
      interventions and total number of pharmacotherapy changes (r=0,5 p<0,05) and 
      between number of interventions and modification of pharmacotherapy with 
      B-blocker, cardiac glycosides and introduction of amiodarone therapy (r=0,47; 
      r=0,30; r=0,32 respectively, p<0,05). CONCLUSIONS: Patients with AF had more 
      changes in ICD parameters, pacing parameters and pharmacotherapy. Patients with 
      lower LVEF had more interventions and more changes in detection of ventricular 
      tachyarrhythmia.
CI  - (c) 2015 MEDPRESS.
FAU - Pudlo, Joanna
AU  - Pudlo J
AD  - Jagiellonian University, Institute of Cardiology, Department of 
      Electrocardiology. The John Paul II Hospital in Krakow.
FAU - Lisznianski, Piotr
AU  - Lisznianski P
AD  - The Hospital in Chrzanow, Department of Cardiology.
FAU - Senderek, Tomasz
AU  - Senderek T
AD  - Jagiellonian University, Institute of Cardiology, Department of 
      Electrocardiology. The John Paul II Hospital in Krakow.
FAU - Lelakowska-Piela, Maria
AU  - Lelakowska-Piela M
AD  - The John Paul II Hospital in Krakow.
FAU - Lelakowski, Jacek
AU  - Lelakowski J
AD  - Jagiellonian University, Institute of Cardiology, Department of 
      Electrocardiology. The John Paul II Hospital in Krakow.
FAU - Nowak, Jacek
AU  - Nowak J
AD  - The Hospital in Chrzanow, Department of Cardiology.
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Czynniki wplywajace na przeprogramowanie implantowanych 
      kardiowerterow-defibrylatorow oraz powody zmian farmakoterapii u chorych z 
      kardiomiopatia rozstrzeniowa w prewencji pierwotnej naglego zgonu sercowego.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Cardiac Glycosides)
SB  - IM
MH  - Adrenergic beta-Antagonists/therapeutic use
MH  - Aged
MH  - Atrial Fibrillation/epidemiology/physiopathology
MH  - Cardiac Glycosides/therapeutic use
MH  - Cardiomyopathy, Dilated/drug therapy/epidemiology/*therapy
MH  - Comorbidity
MH  - Coronary Disease/epidemiology
MH  - Death, Sudden, Cardiac/epidemiology/*prevention & control
MH  - *Defibrillators, Implantable
MH  - Equipment Failure Analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Primary Prevention
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Fibrillation/drug therapy/epidemiology/*therapy
OTO - NOTNLM
OT  - changes in pharmacotherapy
OT  - reprogramming of implantable cardioverter-defibrillators
EDAT- 2015/09/01 06:00
MHDA- 2015/10/10 06:00
CRDT- 2015/08/31 06:00
PHST- 2015/08/31 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2015/10/10 06:00 [medline]
AID - PML230-086 [pii]
PST - ppublish
SO  - Pol Merkur Lekarski. 2015 Aug;39(230):86-90.