PMID- 26319410
OWN - NLM
STAT- MEDLINE
DCOM- 20161219
LR  - 20161230
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 10
IP  - 1
DP  - 2016 Jan-Mar
TI  - Pattern of circulating endothelial-derived microparticles among chronic heart 
      failure patients with dysmetabolic comorbidities: The impact of subclinical 
      hypothyroidism.
PG  - 29-36
LID - S1871-4021(15)00068-5 [pii]
LID - 10.1016/j.dsx.2015.08.001 [doi]
AB  - The study aim was to evaluate the impact of dysmetabolic comorbidities including 
      subclinical hypothyroidism (SH) on pattern of circulating endothelial-derived 
      microparticles (EMPs) in chronic heart failure (CHF) patients. METHODS: It was 
      retrospectively involved a cohort of 388 patients with CHF. Fifty three CHF 
      subjects had SH and 335 patients were free from thyroid dysfunction. Circulating 
      levels of NT-pro brain natriuretic peptide (NT-pro-BNP), high-sensitivity 
      C-reactive protein (hs-CRP), thyroid stimulating hormone (TSH), total and free 
      thyroxine (T4) and triiodothyronine (T3) EMPs were measured at baseline. SH was 
      defined per contemporary clinical guideline as state associated with elevated 
      level of serum TSH>10 muU/L and basal normal free T3 and T4 concentration. 
      RESULTS: Circulating CD31+/annexin V+ EMPs were higher in SH patients compared 
      with none SH subjects. In contrast, activated CD62E+ EMP numbers were not 
      significantly different between both patient cohorts. Using C-statistics for 
      Models with TSH, New York Heart Association (NYHA) class, dyslipidemia, and 
      circulating biomarkers (hs-CRP, NT-proBNP, serum uric acid) as Continuous 
      Variables we found that adding of NYHA class alone, NT-proBNP alone or their 
      combination to the based model (TSH) improved the relative integrated 
      discrimination improvement (IDI) for increased CD31+/annexin V+ to CD62E+ ratio 
      by 4.9%; 9.2% and 9.6% respectively. NT-proBNP improves significantly predictive 
      model based on TSH for increased CD31+/annexin V+ to CD62E+ ratio. Among patient 
      study population for category-free net reclassification improvement (NRI), 4% of 
      events (P=0.026) and 6% of non-events (P=0.012) were correctly reclassified by 
      the addition of circulating NT-proBNP to the base model (TSH) for Increased 
      CD31+/annexin V+ to CD62E+ ratio. Therefore, 4% of events (P=0.028) and 5% of 
      non-events (P=0.014) were correctly reclassified using category-free NRI for 
      increased CD31+/annexin V+ to CD62E+ ratio. CONCLUSION: We found that SH state in 
      CHF patients associates with impaired pattern of circulating EMPs with 
      predominantly increased number of apoptotic-derived microparticles.
CI  - Copyright (c) 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Berezin, Alexander E
AU  - Berezin AE
AD  - Cardiology Unit, Internal Medicine Department, State Medical University, 26, 
      Mayakovsky av., Zaporozhye, UA-69035, Ukraine. Electronic address: 
      dr_berezin@mail.ru.
FAU - Kremzer, Alexander A
AU  - Kremzer AA
AD  - Clinical Pharmacology Department, State Medical University, Zaporozhye, Ukraine.
FAU - Martovitskaya, Yulia V
AU  - Martovitskaya YV
AD  - Pathology Department, State Medical University, Zaporozhye, Ukraine.
FAU - Samura, Tatyana A
AU  - Samura TA
AD  - Clinical Pharmacology Department, State Medical University, Zaporozhye, Ukraine.
FAU - Berezina, Tatyana A
AU  - Berezina TA
AD  - Private Medical Center "Vita-center", Zaporozhye, Ukraine.
LA  - eng
PT  - Journal Article
DEP - 20150821
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Cell-Derived Microparticles/*metabolism
MH  - Chronic Disease
MH  - Computed Tomography Angiography
MH  - Coronary Vessels/diagnostic imaging
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Heart Failure/*complications/diagnostic imaging/metabolism
MH  - Humans
MH  - Hypothyroidism/*complications/diagnostic imaging/metabolism
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Chronic heart failure
OT  - Dysmetabolic comorbidities
OT  - Endothelial-derived microparticles
OT  - Subclinical hypothyroidism
EDAT- 2015/09/01 06:00
MHDA- 2016/12/20 06:00
CRDT- 2015/08/31 06:00
PHST- 2015/08/31 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/12/20 06:00 [medline]
AID - S1871-4021(15)00068-5 [pii]
AID - 10.1016/j.dsx.2015.08.001 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2016 Jan-Mar;10(1):29-36. doi: 10.1016/j.dsx.2015.08.001. 
      Epub 2015 Aug 21.