PMID- 26319500
OWN - NLM
STAT- MEDLINE
DCOM- 20160613
LR  - 20221207
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 22
IP  - 12
DP  - 2015 Dec
TI  - Genetic screening for human leukocyte antigen alleles prior to carbamazepine 
      treatment.
PG  - 1992-3
LID - S0967-5868(15)00389-6 [pii]
LID - 10.1016/j.jocn.2015.05.037 [doi]
AB  - We describe a 28-year-old Malaysian Australian man of Han Chinese descent with 
      toxic epidermal necrolysis (TEN), occurring 2 weeks after commencing 
      carbamazepine. He was subsequently found to be positive for human leukocyte 
      antigen (HLA)-B*1502. Carbamazepine-induced Stevens-Johnson syndrome/TEN is 
      strongly associated with the HLA-B*1502 allele, which is highly prevalent in Han 
      Chinese, Malay, Thai and Indian populations. Prospective screening for the allele 
      may prevent this cutaneous adverse drug reaction from occurring, but many 
      neurologists and other medical practitioners are still unaware of the 
      medico-legal risks of prescribing carbamazepine in susceptible populations and 
      the availability of HLA-B*1502 testing. Performing HLA-B*1502 genotyping and 
      avoiding carbamazepine in at-risk individuals has been proven to decrease 
      incidences of drug-induced TEN. This test is widely available at most large 
      pathology services in Australia, with results available within 2 weeks. The 
      recommendation by regulatory bodies should be strengthened to ensure that the 
      broad medical community is made more aware of this pertinent issue.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Tan, Jeremy C K
AU  - Tan JC
AD  - Department of Dermatology, St George Hospital Sydney, Gray Street, Kogarah, NSW 
      2217, Australia; University of New South Wales, High Street, Kensington, NSW 
      2052, Australia. Electronic address: jeremytck1989@gmail.com.
FAU - Murrell, Dedee F
AU  - Murrell DF
AD  - Department of Dermatology, St George Hospital Sydney, Gray Street, Kogarah, NSW 
      2217, Australia; University of New South Wales, High Street, Kensington, NSW 
      2052, Australia.
FAU - Hersch, Mark I
AU  - Hersch MI
AD  - Department of Neurology, St George Hospital Sydney, Kogarah, NSW, Australia; 
      University of New South Wales, High Street, Kensington, NSW 2052, Australia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150828
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-B*15:02 antigen)
RN  - 0 (HLA-B15 Antigen)
RN  - 33CM23913M (Carbamazepine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Anticonvulsants/*adverse effects
MH  - Asian People/genetics
MH  - Carbamazepine/*adverse effects
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - HLA-B15 Antigen/*genetics
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Prospective Studies
MH  - Stevens-Johnson Syndrome/*genetics
OTO - NOTNLM
OT  - Carbamazepine
OT  - Genetic screening
OT  - HLA-B*1502
OT  - Stevens-Johnson syndrome
OT  - Toxic epidermal necrolysis
EDAT- 2015/09/01 06:00
MHDA- 2016/06/14 06:00
CRDT- 2015/08/31 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/04/29 00:00 [revised]
PHST- 2015/05/01 00:00 [accepted]
PHST- 2015/08/31 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/06/14 06:00 [medline]
AID - S0967-5868(15)00389-6 [pii]
AID - 10.1016/j.jocn.2015.05.037 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2015 Dec;22(12):1992-3. doi: 10.1016/j.jocn.2015.05.037. Epub 
      2015 Aug 28.