PMID- 26319758
OWN - NLM
STAT- MEDLINE
DCOM- 20160105
LR  - 20151003
IS  - 2210-7762 (Print)
VI  - 208
IP  - 10
DP  - 2015 Oct
TI  - Molecular cytogenetics of pediatric adipocytic tumors.
PG  - 469-81
LID - S2210-7762(15)00127-1 [pii]
LID - 10.1016/j.cancergen.2015.06.005 [doi]
AB  - Both epidemiologic and cytogenetic data on pediatric adipose tissue tumors are 
      scarce. Pediatric adipose tumors are mainly represented by lipomas, though only 
      28 cytogenetic descriptions of pediatric lipoma have been reported to date. 
      Similar to adult cases, most of these pediatric lipomas harbored rearrangements 
      of the chromosomal regions 12q14-q15 and 6p21, involving the HMGA2 and HMGA1 
      genes. Further cytogenetic studies of pediatric lipoma would be useful to 
      determinate whether some partner genes of HMGA2, such as NFIB, may have a 
      specific role in the early onset of these tumors. Cytogenetically, the best 
      documented pediatric adipose tumor is lipoblastoma, which is the second most 
      frequent adipose tumor in children. Chromosomal alterations in lipoblastoma, 
      observed in 61% of cases studied by conventional cytogenetics, typically involve 
      the 8q11-q12 region. The target gene of this rearrangement is PLAG1. Anomalies of 
      PLAG1 have been observed in 70% of cases of pediatric adipose tumors studied by 
      molecular cytogenetics methods, such as fluorescence in situ hybridization (FISH) 
      or comparative genomic hybridization on array (array-CGH). The rare described 
      cases of malignant pediatric adipose tumors in children are mostly myxoid 
      liposarcomas. In the 27 cases explored at the genetic level, all pediatric myxoid 
      liposarcomas showed the classical rearrangement of the DDIT3 gene at 12q13. In 
      conclusion, the epidemiology and the prevalence of histological types of adipose 
      tissue tumors differ in the pediatric population compared with adults, whereas 
      chromosomal and genic rearrangements are similar to those of adult cases in each 
      histological type.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Dadone, Berengere
AU  - Dadone B
AD  - Laboratory of Solid Tumors Genetics, Nice University Hospital, Faculty of 
      Medicine, Nice, France; Institute for Research on Cancer and Aging of Nice 
      (IRCAN), CNRS UMR 7284/INSERM U1081, University of Nice - Sophia Antipolis, 
      Faculty of Medicine, Nice, France.
FAU - Refae, Sadal
AU  - Refae S
AD  - Laboratory of Solid Tumors Genetics, Nice University Hospital, Faculty of 
      Medicine, Nice, France; Institute for Research on Cancer and Aging of Nice 
      (IRCAN), CNRS UMR 7284/INSERM U1081, University of Nice - Sophia Antipolis, 
      Faculty of Medicine, Nice, France.
FAU - Lemarie-Delaunay, Camille
AU  - Lemarie-Delaunay C
AD  - Department of Pathology, Brabois Hospital, Vandoeuvre-les-Nancy, France.
FAU - Bianchini, Laurence
AU  - Bianchini L
AD  - Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR 7284/INSERM 
      U1081, University of Nice - Sophia Antipolis, Faculty of Medicine, Nice, France.
FAU - Pedeutour, Florence
AU  - Pedeutour F
AD  - Laboratory of Solid Tumors Genetics, Nice University Hospital, Faculty of 
      Medicine, Nice, France; Institute for Research on Cancer and Aging of Nice 
      (IRCAN), CNRS UMR 7284/INSERM U1081, University of Nice - Sophia Antipolis, 
      Faculty of Medicine, Nice, France. Electronic address: 
      florence.pedeutour@unice.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150626
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
RN  - 0 (Recombinant Fusion Proteins)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Chromosome Aberrations
MH  - Cytogenetic Analysis
MH  - Humans
MH  - Infant
MH  - Lipoblastoma/*epidemiology/*genetics/pathology
MH  - Liposarcoma/*epidemiology/*genetics/pathology
MH  - Prevalence
MH  - Recombinant Fusion Proteins/genetics
OTO - NOTNLM
OT  - Lipoma
OT  - cytogenetics
OT  - lipoblastoma
OT  - liposarcoma
OT  - pediatric tumors
EDAT- 2015/09/01 06:00
MHDA- 2016/01/06 06:00
CRDT- 2015/08/31 06:00
PHST- 2015/04/16 00:00 [received]
PHST- 2015/06/16 00:00 [revised]
PHST- 2015/06/23 00:00 [accepted]
PHST- 2015/08/31 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/01/06 06:00 [medline]
AID - S2210-7762(15)00127-1 [pii]
AID - 10.1016/j.cancergen.2015.06.005 [doi]
PST - ppublish
SO  - Cancer Genet. 2015 Oct;208(10):469-81. doi: 10.1016/j.cancergen.2015.06.005. Epub 
      2015 Jun 26.