PMID- 26320859
OWN - NLM
STAT- MEDLINE
DCOM- 20161012
LR  - 20190109
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Print)
IS  - 0303-7207 (Linking)
VI  - 421
DP  - 2016 Feb 5
TI  - Animal models of pituitary neoplasia.
PG  - 68-81
LID - S0303-7207(15)30064-2 [pii]
LID - 10.1016/j.mce.2015.08.024 [doi]
AB  - Pituitary neoplasias can occur as part of a complex inherited disorder, or more 
      commonly as sporadic (non-familial) disease. Studies of the molecular and genetic 
      mechanisms causing such pituitary tumours have identified dysregulation of >35 
      genes, with many revealed by studies in mice, rats and zebrafish. Strategies used 
      to generate these animal models have included gene knockout, gene knockin and 
      transgenic over-expression, as well as chemical mutagenesis and drug induction. 
      These animal models provide an important resource for investigation of 
      tissue-specific tumourigenic mechanisms, and evaluations of novel therapies, 
      illustrated by studies into multiple endocrine neoplasia type 1 (MEN1), a 
      hereditary syndrome in which  approximately  30% of patients develop pituitary adenomas. This 
      review describes animal models of pituitary neoplasia that have been generated, 
      together with some recent advances in gene editing technologies, and an 
      illustration of the use of the Men1 mouse as a pre clinical model for evaluating 
      novel therapies.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights 
      reserved.
FAU - Lines, K E
AU  - Lines KE
AD  - Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, 
      Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill 
      Hospital, Headington, Oxford OX3 7LJ, UK.
FAU - Stevenson, M
AU  - Stevenson M
AD  - Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, 
      Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill 
      Hospital, Headington, Oxford OX3 7LJ, UK.
FAU - Thakker, R V
AU  - Thakker RV
AD  - Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, 
      Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill 
      Hospital, Headington, Oxford OX3 7LJ, UK. Electronic address: 
      rajesh.thakker@ndm.ox.ac.uk.
LA  - eng
GR  - G1000467/Medical Research Council/United Kingdom
GR  - G9825289/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150828
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mice
MH  - Models, Animal
MH  - Pituitary Neoplasms/*genetics/*pathology/therapy
MH  - Proto-Oncogene Proteins/*genetics
MH  - Rats
MH  - Zebrafish
PMC - PMC4721536
OTO - NOTNLM
OT  - Adenoma
OT  - Carcinoma
OT  - Mouse
OT  - Multiple endocrine neoplasia type 1
OT  - Pituitary
OT  - Rat
EDAT- 2015/09/01 06:00
MHDA- 2016/10/13 06:00
PMCR- 2016/02/05
CRDT- 2015/09/01 06:00
PHST- 2015/07/31 00:00 [received]
PHST- 2015/08/25 00:00 [revised]
PHST- 2015/08/25 00:00 [accepted]
PHST- 2015/09/01 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/10/13 06:00 [medline]
PHST- 2016/02/05 00:00 [pmc-release]
AID - S0303-7207(15)30064-2 [pii]
AID - 10.1016/j.mce.2015.08.024 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2016 Feb 5;421:68-81. doi: 10.1016/j.mce.2015.08.024. Epub 
      2015 Aug 28.