PMID- 26321925
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150831
LR  - 20201001
IS  - 1662-5137 (Print)
IS  - 1662-5137 (Electronic)
IS  - 1662-5137 (Linking)
VI  - 9
DP  - 2015
TI  - Bidirectional interactions between neuronal and hemodynamic responses to 
      transcranial direct current stimulation (tDCS): challenges for brain-state 
      dependent tDCS.
PG  - 107
LID - 10.3389/fnsys.2015.00107 [doi]
LID - 107
AB  - Transcranial direct current stimulation (tDCS) has been shown to modulate 
      cortical neural activity. During neural activity, the electric currents from 
      excitable membranes of brain tissue superimpose in the extracellular medium and 
      generate a potential at scalp, which is referred as the electroencephalogram 
      (EEG). Respective neural activity (energy demand) has been shown to be closely 
      related, spatially and temporally, to cerebral blood flow (CBF) that supplies 
      glucose (energy supply) via neurovascular coupling. The hemodynamic response can 
      be captured by near-infrared spectroscopy (NIRS), which enables continuous 
      monitoring of cerebral oxygenation and blood volume. This neurovascular coupling 
      phenomenon led to the concept of neurovascular unit (NVU) that consists of the 
      endothelium, glia, neurons, pericytes, and the basal lamina. Here, recent works 
      suggest NVU as an integrated system working in concert using feedback mechanisms 
      to enable proper brain homeostasis and function where the challenge remains in 
      capturing these mostly nonlinear spatiotemporal interactions within NVU for 
      brain-state dependent tDCS. In principal accordance, we propose EEG-NIRS-based 
      whole-head monitoring of tDCS-induced neuronal and hemodynamic alterations during 
      tDCS.
FAU - Dutta, Anirban
AU  - Dutta A
AD  - INRIA (Sophia Antipolis) - CNRS: UMR5506 - Universite Montpellier Montpellier, 
      France ; Laboratoire d'Informatique de Robotique et de Microelectronique de 
      Montpellier (LIRMM), CNRS: UMR5506 - Universite Montpellier Montpellier, France.
LA  - eng
PT  - Journal Article
DEP - 20150810
PL  - Switzerland
TA  - Front Syst Neurosci
JT  - Frontiers in systems neuroscience
JID - 101477946
PMC - PMC4530593
OTO - NOTNLM
OT  - electroencephalogram
OT  - hemo-neural hypothesis
OT  - near-infrared spectroscopy
OT  - neurovascular coupling
OT  - transcranial direct current stimulation
EDAT- 2015/09/01 06:00
MHDA- 2015/09/01 06:01
PMCR- 2015/01/01
CRDT- 2015/09/01 06:00
PHST- 2015/04/02 00:00 [received]
PHST- 2015/07/13 00:00 [accepted]
PHST- 2015/09/01 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2015/09/01 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnsys.2015.00107 [doi]
PST - epublish
SO  - Front Syst Neurosci. 2015 Aug 10;9:107. doi: 10.3389/fnsys.2015.00107. 
      eCollection 2015.