PMID- 26321934
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150831
LR  - 20201001
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 9
DP  - 2015
TI  - Anticipatory pleasure predicts effective connectivity in the mesolimbic system.
PG  - 217
LID - 10.3389/fnbeh.2015.00217 [doi]
LID - 217
AB  - Convergent evidence suggests the important role of the mesolimbic pathway in 
      anticipating monetary rewards. However, the underlying mechanism of how the 
      sub-regions interact with each other is still not clearly understood. Using 
      dynamic causal modeling, we constructed a reward-related network for anticipating 
      monetary reward using the Monetary Incentive Delay Task. Twenty-six healthy 
      adolescents (Female/Male = 11/15; age = 18.69 +/- 1.35 years; education = 12 +/- 1.58 
      years) participated in the present study. The best-fit network involved the right 
      substantia nigra/ventral tegmental area (SN/VTA), the right nucleus accumbens 
      (NAcc) and the right thalamus, which were all activated during anticipation of 
      monetary gain and loss. The SN/VTA directly activates the NAcc and the thalamus. 
      More importantly, monetary gain modulated the connectivity from the SN/VTA to the 
      NAcc and this was significantly correlated with subjective anticipatory pleasure 
      (r = 0.649, p < 0.001). Our findings suggest that activity in the mesolimbic 
      pathway during the anticipation of monetary reward could to some extent be 
      predicted by subjective anticipatory pleasure.
FAU - Li, Zhi
AU  - Li Z
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, 
      China ; The University of Chinese Academy of Sciences Beijing, China.
FAU - Yan, Chao
AU  - Yan C
AD  - Key Laboratory of Brain Functional Genomics (MOE and STCSM), School of Psychology 
      and Cognitive Science, East China Normal University Shanghai, China.
FAU - Xie, Wei-Zhen
AU  - Xie WZ
AD  - Department of Psychology, University of California Riverside, CA, USA.
FAU - Li, Ke
AU  - Li K
AD  - MRI Center, Hospital 306 of PLA Beijing, China.
FAU - Zeng, Ya-Wei
AU  - Zeng YW
AD  - MRI Center, Hospital 306 of PLA Beijing, China.
FAU - Jin, Zhen
AU  - Jin Z
AD  - MRI Center, Hospital 306 of PLA Beijing, China.
FAU - Cheung, Eric F C
AU  - Cheung EF
AD  - Castle Peak Hospital, Hong Kong Special Administrative Region Tuen Mun, China.
FAU - Chan, Raymond C K
AU  - Chan RC
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20150812
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC4532926
OTO - NOTNLM
OT  - anticipatory pleasure
OT  - dynamic causal modeling
OT  - hedonic capacity
OT  - monetary reward
EDAT- 2015/09/01 06:00
MHDA- 2015/09/01 06:01
PMCR- 2015/01/01
CRDT- 2015/09/01 06:00
PHST- 2015/06/01 00:00 [received]
PHST- 2015/07/30 00:00 [accepted]
PHST- 2015/09/01 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2015/09/01 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2015.00217 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2015 Aug 12;9:217. doi: 10.3389/fnbeh.2015.00217. 
      eCollection 2015.