PMID- 26322834
OWN - NLM
STAT- MEDLINE
DCOM- 20151027
LR  - 20220310
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 9
DP  - 2015 Aug
TI  - Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of 
      Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2.
PG  - 5698-705
LID - 10.1167/iovs.15-16708 [doi]
AB  - PURPOSE: To identify eyes of patients with diabetes type 2 that show progression 
      of retinal disease within a 1-year period using noninvasive techniques. METHODS: 
      Three hundred seventy-four type 2 diabetic patients with mild nonproliferative 
      diabetic retinopathy (Early Treatment Diabetic Retinopathy Study [ETDRS] level 20 
      or 35) were included in a 12-month prospective observational study to identify 
      retinopathy progression. Four visits were scheduled at 0, 3, 6, and 12 months. 
      Microaneurysm (MA) activity using the RetmarkerDR and retinal thickness using 
      spectral-domain optical coherence tomography (SD-OCT) were assessed by a central 
      reading center at all visits and ETDRS severity level in the first and last 
      visits. RESULTS: Three hundred thirty-one eyes/patients completed the study. 
      Microaneurysm formation rate greater than or equal to 2 was present in 68.1% of 
      the eyes and MA turnover greater than or equal to 6 in 54.0% at month 6. Higher 
      MA turnover values were registered in eyes that showed progression in ETDRS 
      severity level (P < 0.03). There were also significant correlations between 
      increased microaneurysm activity and increases in retinal thickness. 
      Spectral-domain OCT identified clinical macular edema in 24 eyes/patients (6.7%) 
      and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. 
      Progression of retinal thickening was registered in eyes that had either 
      subclinical or clinical macular edema at baseline. CONCLUSIONS: Changes in MA 
      activity measured with RetmarkerDR and in central retinal thickness in eyes with 
      mild nonproliferative diabetic retinopathy and diabetes type 2 are able to 
      identify eyes at risk of progression. These eyes/patients should be selected for 
      inclusion in future clinical trials of drugs targeted to prevent diabetic 
      retinopathy progression to vision-threatening complications. (ClinicalTrials.gov 
      number, NCT01145599.)
FAU - Ribeiro, Luisa
AU  - Ribeiro L
AD  - Association for Innovation and Biomedical Research on Light and Image (AIBILI) 
      Coimbra, Portugal.
FAU - Bandello, Francesco
AU  - Bandello F
AD  - Department of Ophthalmology, University Vita Salute-Scientific Institute of San 
      Raffael, Milan, Italy.
FAU - Tejerina, Amparo Navea
AU  - Tejerina AN
AD  - Fundacion para la Investigacion Biomedica y Sanitaria, FISABIO-OFTALMOLOGIA, 
      Valencia, Spain.
FAU - Vujosevic, Stela
AU  - Vujosevic S
AD  - Centre for Clinical Trials, Department of Ophthalmology, University of Padova, 
      Padova, Italy.
FAU - Varano, Monica
AU  - Varano M
AD  - G.B. Bietti Eye Foundation-IRCCS, Rome, Italy.
FAU - Egan, Catherine
AU  - Egan C
AD  - Clinical Trials Unit, Moorfields Eye Hospital, NHS Foundation Trust, London, 
      United Kingdom.
FAU - Sivaprasad, Sobha
AU  - Sivaprasad S
AD  - Laser and Retinal Research Unit, King's Health Partners, London, United Kingdom.
FAU - Menon, Geeta
AU  - Menon G
AD  - Ophthalmology Clinical Trials Unit, Frimley Park Hospital Foundation Trust, 
      Frimley, United Kingdom.
FAU - Massin, Pascale
AU  - Massin P
AD  - Department of Ophthalmology, Lariboisiere Hospital, Paris, France.
FAU - Verbraak, Frank D
AU  - Verbraak FD
AD  - Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands.
FAU - Lund-Andersen, Henrik
AU  - Lund-Andersen H
AD  - Department of Ophthalmology, Glostrup Hospital, Copenhagen University, Glostrup, 
      Denmark.
FAU - Martinez, Jose P
AU  - Martinez JP
AD  - Rotterdam Eye Hospital, Rotterdam, The Netherlands.
FAU - Jurgens, Ignasi
AU  - Jurgens I
AD  - Institut Catala de Retina (ICR), Barcelona, Spain.
FAU - Smets, Erica
AU  - Smets E
AD  - Antwerp University Hospital, Department of Ophthalmology, Antwerp, Belgium.
FAU - Coriat, Caroline
AU  - Coriat C
AD  - Centre d'Investigation Clinique, Centre National d'Ophtalmologie des 
      Quinze-Vingts, Paris, France.
FAU - Wiedemann, Peter
AU  - Wiedemann P
AD  - University Eye Hospital Leipzig, Leipzig, Germany.
FAU - Agoas, Victor
AU  - Agoas V
AD  - Instituto de Oftalmologia Dr. Gama Pinto, Lisboa, Portugal.
FAU - Querques, Giuseppe
AU  - Querques G
AD  - Centre Hospitalier Intercommunal de Creteil, University Paris-Est Creteil, 
      Creteil, France.
FAU - Holz, Frank G
AU  - Holz FG
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Nunes, Sandrina
AU  - Nunes S
AD  - Association for Innovation and Biomedical Research on Light and Image (AIBILI) 
      Coimbra, Portugal.
FAU - Neves, Catarina
AU  - Neves C
AD  - Association for Innovation and Biomedical Research on Light and Image (AIBILI) 
      Coimbra, Portugal.
FAU - Cunha-Vaz, Jose
AU  - Cunha-Vaz J
AD  - Association for Innovation and Biomedical Research on Light and Image (AIBILI) 
      Coimbra, Portugal.
CN  - Evicr Net Study Group
LA  - eng
SI  - ClinicalTrials.gov/NCT01145599
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Retinopathy/*diagnosis/etiology/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Retina/*pathology
MH  - Time Factors
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
FIR - Ribeiro, Luisa
IR  - Ribeiro L
FIR - Figueira, Joao
IR  - Figueira J
FIR - Pires, Isabel
IR  - Pires I
FIR - Leal, Sergio
IR  - Leal S
FIR - Simao, Silvia
IR  - Simao S
FIR - Santos, Ana Rita
IR  - Santos AR
FIR - Simoes, Isabel
IR  - Simoes I
FIR - Querques, Giuseppe
IR  - Querques G
FIR - Souied, Eric H
IR  - Souied EH
FIR - Coriat, Caroline
IR  - Coriat C
FIR - Egan, Catherine
IR  - Egan C
FIR - Boston, Hayley
IR  - Boston H
FIR - Degli Esposti, Simona
IR  - Degli Esposti S
FIR - Rocco, Vincent
IR  - Rocco V
FIR - Smets, Erica
IR  - Smets E
FIR - Mathysen, Danny G P
IR  - Mathysen DG
FIR - Massin, Pascale
IR  - Massin P
FIR - Erginay, Ali
IR  - Erginay A
FIR - Holz, Frank G
IR  - Holz FG
FIR - Fleckenstein, Monika
IR  - Fleckenstein M
FIR - Varano, Monica
IR  - Varano M
FIR - Cacciamani, Andrea
IR  - Cacciamani A
FIR - Parravano, Mariacristina
IR  - Parravano M
FIR - Cosimi, Pamela
IR  - Cosimi P
FIR - Verbraak, Frank
IR  - Verbraak F
FIR - Mourits, M
IR  - Mourits M
FIR - Schlingemann, R O
IR  - Schlingemann R
FIR - Wezel, M
IR  - Wezel M
FIR - Jansen-Kok, C
IR  - Jansen-Kok C
FIR - Althoff, A
IR  - Althoff A
FIR - de Vries, D
IR  - de Vries D
FIR - Stam, M
IR  - Stam M
FIR - Wiedemann, Peter
IR  - Wiedemann P
FIR - Jochmann, Claudia
IR  - Jochmann C
FIR - Koch, Christian
IR  - Koch C
FIR - Vollhardt, Daniela
IR  - Vollhardt D
FIR - Tilgner, Christina
IR  - Tilgner C
FIR - Pinto, Gama
IR  - Pinto G
FIR - Agoas, Victor
IR  - Agoas V
FIR - Camacho, Pedro
IR  - Camacho P
FIR - Lund-Andersen, Henrik
IR  - Lund-Andersen H
FIR - Jurgens, Ignasi
IR  - Jurgens I
FIR - Vila, Daniel
IR  - Vila D
FIR - Morilla, Antonio
IR  - Morilla A
FIR - Gonzalez, Lluis
IR  - Gonzalez L
FIR - Martinez, Victor
IR  - Martinez V
FIR - Pedros, Gemma
IR  - Pedros G
FIR - Garcia, Mireia
IR  - Garcia M
FIR - Aradilla, Yolanda
IR  - Aradilla Y
FIR - Martinez, Alexia
IR  - Martinez A
FIR - Escude, Raimon
IR  - Escude R
FIR - Vujosevic, Stela
IR  - Vujosevic S
FIR - Midena, Edoardo
IR  - Midena E
FIR - Martini, Ferdinando
IR  - Martini F
FIR - Urban, Francesca
IR  - Urban F
FIR - Daniele, Anna Rita
IR  - Daniele AR
FIR - Martinez, Jose
IR  - Martinez J
FIR - Tejerina, Amparo Navea
IR  - Tejerina AN
FIR - Fernandez-Lopez, Ester
IR  - Fernandez-Lopez E
FIR - Fandino, Adriana
IR  - Fandino A
FIR - Carmen, M
IR  - Carmen M
FIR - Jord, Pablo Perez
IR  - Jord PP
FIR - Menon, Geeta
IR  - Menon G
FIR - Chandran, Manju
IR  - Chandran M
FIR - North, Lorraine
IR  - North L
FIR - Robson, Deana
IR  - Robson D
FIR - Chekuri, Maheswari
IR  - Chekuri M
FIR - Bandello, Francesco
IR  - Bandello F
FIR - Lattanzio, Rosangela
IR  - Lattanzio R
FIR - Del Turco, Claudia
IR  - Del Turco C
FIR - Alto, Giorgio
IR  - Alto G
FIR - Buzzotta, Alessio
IR  - Buzzotta A
FIR - Marelli, Marta
IR  - Marelli M
FIR - Ribecca, Antonella
IR  - Ribecca A
FIR - Sivaprasad, Sobha
IR  - Sivaprasad S
FIR - Crosby-Nwaobi, Roxanne
IR  - Crosby-Nwaobi R
FIR - Schwartz, Christian
IR  - Schwartz C
FIR - Simao, Silvia
IR  - Simao S
FIR - Neves, Catarina
IR  - Neves C
FIR - Pita, Rui
IR  - Pita R
FIR - Ribeiro, Luisa
IR  - Ribeiro L
FIR - Santos, Ana Rita
IR  - Santos AR
FIR - Ecsodi, Joana
IR  - Ecsodi J
FIR - Nunes, Sandrina
IR  - Nunes S
FIR - Simoes, Sonia
IR  - Simoes S
FIR - Nunes, Sandrina
IR  - Nunes S
FIR - Costa, Miguel
IR  - Costa M
FIR - Cunha-Vaz, Jose
IR  - Cunha-Vaz J
FIR - Martinho, Cecilia
IR  - Martinho C
FIR - Fernandes, Rita
IR  - Fernandes R
EDAT- 2015/09/01 06:00
MHDA- 2015/10/28 06:00
CRDT- 2015/09/01 06:00
PHST- 2015/09/01 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2015/10/28 06:00 [medline]
AID - 2434745 [pii]
AID - 10.1167/iovs.15-16708 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5698-705. doi: 10.1167/iovs.15-16708.