PMID- 26322951
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20191210
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 115
DP  - 2015 Nov 10
TI  - Combination of counterpropagation artificial neural networks and antioxidant 
      activities for comprehensive evaluation of associated-extraction efficiency of 
      various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.
PG  - 580-6
LID - S0731-7085(15)30104-7 [pii]
LID - 10.1016/j.jpba.2015.08.006 [doi]
AB  - Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat 
      hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to 
      minimize problems relative to medicine bioavailability, such as low solubility 
      and poor stability. The objective of this study was to determine the 
      associated-extraction efficiency of various CDs in XZN. Three various type CDs 
      were evaluated, including native CDs (alpha-CD, beta-CD), hydrophilic CD derivatives 
      (HP-beta-CD and Me-beta-CD), and ionic CD derivatives (SBE-beta-CD and CM-beta-CD). An ultra 
      high-performance liquid chromatography (UHPLC) fingerprint was applied to 
      determine the components in CD extracts and original aqueous extract (OAE). A 
      counterpropagation artificial neural network (CP-ANN) was used to analyze the 
      components in different extracts and compare the selective extraction of various 
      CDs. Extraction efficiencies of the various CDs in terms of extracted components 
      follow the ranking, ionic CD derivatives>hydrophilic CD derivatives>native 
      CDs>OAE. Besides, different types of CDs have their own selective extraction and 
      ionic CD derivatives present the strongest associated-extraction efficiency. 
      Antioxidant potentials of various extracts were evaluated by determining the 
      inhibition of spontaneous, H2O2-induced, CCl4-induced and Fe(2+)/ascorbic 
      acid-induced lipid peroxidation (LPO) and analyzing the scavenging capacity for 
      DPPH and hydroxyl radicals. The order of extraction efficiencies of the various 
      CDs relative to antioxidant activities is as follows: 
      SBE-beta-CD>CM-beta-CD>HP-beta-CD>Me-beta-CD>beta-CD>alpha-CD. It can be demonstrated that all of 
      the CDs studied increase the extraction efficiency and that ionic CD derivatives 
      (SBE-beta-CD and CM-beta-CD) present the highest extraction capability in terms of 
      amount extracted and antioxidant activities of extracts.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Sun, Lili
AU  - Sun L
AD  - School of Chinese Materia Medica, Tianjin University of Traditional Chinese 
      Medicine, Tianjin, 300193, China.
FAU - Yang, Jianwen
AU  - Yang J
AD  - School of Chinese Materia Medica, Tianjin University of Traditional Chinese 
      Medicine, Tianjin, 300193, China.
FAU - Wang, Meng
AU  - Wang M
AD  - Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of 
      Traditional Chinese Medicine, Tianjin, 300193, China.
FAU - Zhang, Huijie
AU  - Zhang H
AD  - School of Chinese Materia Medica, Tianjin University of Traditional Chinese 
      Medicine, Tianjin, 300193, China.
FAU - Liu, Yanan
AU  - Liu Y
AD  - School of Chinese Materia Medica, Tianjin University of Traditional Chinese 
      Medicine, Tianjin, 300193, China.
FAU - Ren, Xiaoliang
AU  - Ren X
AD  - School of Chinese Materia Medica, Tianjin University of Traditional Chinese 
      Medicine, Tianjin, 300193, China. Electronic address: renxiaoliang@tjutcm.edu.cn.
FAU - Qi, Aidi
AU  - Qi A
AD  - School of Chinese Materia Medica, Tianjin University of Traditional Chinese 
      Medicine, Tianjin, 300193, China.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150812
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Antioxidants)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Cyclodextrins)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Picrates)
RN  - 0 (xue-zhi-ning)
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
SB  - IM
MH  - Antioxidants/chemistry/*isolation & purification/pharmacology
MH  - Biphenyl Compounds/chemistry
MH  - Chemistry, Pharmaceutical
MH  - Chromatography, High Pressure Liquid
MH  - Cyclodextrins/*chemistry
MH  - Drugs, Chinese Herbal/chemistry/*isolation & purification/pharmacology
MH  - Hydroxyl Radical/chemistry
MH  - Lipid Peroxidation
MH  - *Neural Networks, Computer
MH  - Picrates/chemistry
MH  - Technology, Pharmaceutical/*methods
OTO - NOTNLM
OT  - Antioxidant activities
OT  - Associated-extraction efficiency
OT  - Counterpropagation artificial neural network (CP-ANN)
OT  - Cyclodextrins
OT  - Kohonen maps
OT  - Traditional Chinese formula Xue-Zhi-Ning (XZN)
EDAT- 2015/09/01 06:00
MHDA- 2016/07/07 06:00
CRDT- 2015/09/01 06:00
PHST- 2015/07/10 00:00 [received]
PHST- 2015/08/03 00:00 [revised]
PHST- 2015/08/06 00:00 [accepted]
PHST- 2015/09/01 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
AID - S0731-7085(15)30104-7 [pii]
AID - 10.1016/j.jpba.2015.08.006 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2015 Nov 10;115:580-6. doi: 10.1016/j.jpba.2015.08.006. Epub 
      2015 Aug 12.