PMID- 26323654
OWN - NLM
STAT- MEDLINE
DCOM- 20170111
LR  - 20170112
IS  - 1535-6302 (Electronic)
IS  - 0363-0188 (Linking)
VI  - 45
IP  - 3
DP  - 2016 May-Jun
TI  - High-Attenuation Mucus Impaction in Patients With Allergic Bronchopulmonary 
      Aspergillosis: Objective Criteria on High-Resolution Computed Tomography and 
      Correlation With Serologic Parameters.
PG  - 168-73
LID - S0363-0188(15)00109-7 [pii]
LID - 10.1067/j.cpradiol.2015.07.006 [doi]
AB  - The aim of the study was to correlate the high-resolution computed tomography 
      (HRCT) finding of high-attenuation mucus (HAM) impaction, including mean CT 
      density and immunologic parameters in patients with allergic bronchopulmonary 
      aspergillosis (ABPA). The institutional review board approved the study, and 
      informed written consent was obtained. A total of 100 consecutive patients 
      diagnosed with ABPA between June 2012 and December 2013 undergoing HRCT were 
      enrolled. HRCT scan of the chest was evaluated for central bronchiectasis, mucoid 
      impaction, and number of involved bronchial segments. Findings of mucoid 
      impaction in patients were classified as HAM and non-HAM. CT attenuation values 
      and mean CT density were calculated. Serologic parameters were assessed for total 
      immunoglobin E (IgE), specific IgE, and absolute eosinophil count. Patients with 
      HAM impaction on HRCT were found to have significantly higher levels of total IgE 
      (P < 0.001), specific IgE (P = 0.03), and number of bronchial segments affected 
      (P < 0.001). We found a CT density value of 70 Hounsfield units (HU) as an 
      adequate cutoff value for HAM impaction. CT density >100HU is correlated with 
      significantly higher values of serologic parameters. The present study suggests a 
      relation between absolute HU values of HAM impaction and absolute value of 
      serologic parameters in ABPA.
CI  - Copyright (c) 2015 Mosby, Inc. All rights reserved.
FAU - Phuyal, Subash
AU  - Phuyal S
AD  - Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical 
      Education and Research (PGIMER), Chandigarh, India.
FAU - Garg, Mandeep Kumar
AU  - Garg MK
AD  - Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical 
      Education and Research (PGIMER), Chandigarh, India. Electronic address: 
      gargmandeep@hotmail.com.
FAU - Agarwal, Ritesh
AU  - Agarwal R
AD  - Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and 
      Research (PGIMER), Chandigarh, India.
FAU - Gupta, Pankaj
AU  - Gupta P
AD  - Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical 
      Education and Research (PGIMER), Chandigarh, India.
FAU - Chakrabarti, Arunaloke
AU  - Chakrabarti A
AD  - Department of Medical Microbiology, Postgraduate Institute of Medical Education 
      and Research (PGIMER), Chandigarh, India.
FAU - Sandhu, Manavjit Singh
AU  - Sandhu MS
AD  - Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical 
      Education and Research (PGIMER), Chandigarh, India.
FAU - Khandelwal, Niranjan
AU  - Khandelwal N
AD  - Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical 
      Education and Research (PGIMER), Chandigarh, India.
LA  - eng
PT  - Journal Article
DEP - 20150810
PL  - United States
TA  - Curr Probl Diagn Radiol
JT  - Current problems in diagnostic radiology
JID - 7607123
SB  - IM
MH  - Adult
MH  - Aspergillosis, Allergic Bronchopulmonary/*blood/*diagnostic imaging/immunology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mucus/*diagnostic imaging/immunology
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2015/09/02 06:00
MHDA- 2017/01/12 06:00
CRDT- 2015/09/02 06:00
PHST- 2015/06/12 00:00 [received]
PHST- 2015/07/15 00:00 [accepted]
PHST- 2015/09/02 06:00 [entrez]
PHST- 2015/09/02 06:00 [pubmed]
PHST- 2017/01/12 06:00 [medline]
AID - S0363-0188(15)00109-7 [pii]
AID - 10.1067/j.cpradiol.2015.07.006 [doi]
PST - ppublish
SO  - Curr Probl Diagn Radiol. 2016 May-Jun;45(3):168-73. doi: 
      10.1067/j.cpradiol.2015.07.006. Epub 2015 Aug 10.