PMID- 26323659
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 26
IP  - 5
DP  - 2016 May
TI  - Is a Simple Food-Diverting Operation the Solution for Type 2 Diabetes Treatment? 
      Experimental Study in a Non-Obese Rat Model.
PG  - 1010-5
LID - 10.1007/s11695-015-1871-8 [doi]
AB  - BACKGROUND: The feasibility of a side-to-side jejunoileal anastomosis (SJA) to 
      control type 2 diabetes mellitus (T2DM) was studied in non-obese diabetic 
      Goto-Kakizaki (GK) rats. METHODS: Seventeen 14-week-old male GK rats were divided 
      into three groups: SJA bypassing 60% of the small bowel length, sham-operated 
      jejunoileal bypass (Sham group), and control animals. Rats were observed for 10 
      weeks after surgery. Fasting blood glucose (FBG) levels and oral glucose 
      tolerance test (OGTT) were measured before and after the procedure. RESULTS: 
      Animals with SJA exhibited normalization of FBG levels from the 1st and up to the 
      10th postoperative week when the experiment terminated. OGTT compared with 
      sham-operated and control groups was also significantly better at 3 and 8 weeks 
      postoperatively. CONCLUSIONS: A simple SJA, diverting the food and 
      biliopancreatic secretion to the distal small bowel, was able to normalize both 
      FBG levels and OGTT in a non-obese diabetic rat model.
FAU - Melissas, John
AU  - Melissas J
AD  - Bariatric Unit, Department of Surgical Oncology, University of Crete, 164 
      Erythreas str, Heraklion, 71409, Greece. melissas@med.uoc.gr.
FAU - Peirasmakis, Drakos
AU  - Peirasmakis D
AD  - Bariatric Unit, Department of Surgical Oncology, University of Crete, 164 
      Erythreas str, Heraklion, 71409, Greece.
FAU - Lamprou, Vasileios
AU  - Lamprou V
AD  - Bariatric Unit, Department of Surgical Oncology, University of Crete, 164 
      Erythreas str, Heraklion, 71409, Greece.
FAU - Papadakis, John
AU  - Papadakis J
AD  - Department of Medicine, Heraklion University Hospital, Medical School, University 
      of Crete, Heraklion, Greece.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/metabolism/pathology/*surgery
MH  - Diabetes Mellitus, Type 2/metabolism/pathology/*surgery
MH  - Feasibility Studies
MH  - Glucose Tolerance Test
MH  - Insulin/blood
MH  - Intestine, Small/surgery
MH  - *Jejunoileal Bypass
MH  - Male
MH  - Rats
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Diabetes type 2
OT  - Goto-Kakizaki rat
OT  - Jejunoileal anastomosis
OT  - Metabolic surgery
EDAT- 2015/09/02 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/09/02 06:00
PHST- 2015/09/02 06:00 [entrez]
PHST- 2015/09/02 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1007/s11695-015-1871-8 [pii]
AID - 10.1007/s11695-015-1871-8 [doi]
PST - ppublish
SO  - Obes Surg. 2016 May;26(5):1010-5. doi: 10.1007/s11695-015-1871-8.