PMID- 26324785
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20161126
IS  - 1502-7732 (Electronic)
IS  - 0300-9742 (Linking)
VI  - 45
IP  - 3
DP  - 2016
TI  - Subclinical left ventricular dysfunction in childhood-onset systemic lupus 
      erythematosus: a two-dimensional speckle-tracking echocardiographic study.
PG  - 202-9
LID - 10.3109/03009742.2015.1063686 [doi]
AB  - OBJECTIVES: The main purpose of the study was to investigate left ventricular 
      (LV) subclinical systolic and diastolic dysfunction in childhood-onset systemic 
      lupus erythematosus (c-SLE) patients using two-dimensional speckle-tracking 
      (2DST) echocardiography. We also interrogated possible correlations between 
      impairment of myocardial deformation and the SLE Disease Activity Index 2000 
      (SLEDAI-2K), as well as the presence of traditional and disease-related 
      cardiovascular risk factors (CRFs). METHOD: A total of 50 asymptomatic patients 
      and 50 controls (age 14.74 vs. 14.82 years, p = 0.83) were evaluated by standard 
      and 2DST echocardiography. RESULTS: Despite a normal ejection fraction (EF), 
      there was reduction in all parameters of LV longitudinal and radial deformation 
      in patients compared to controls: peak longitudinal systolic strain (PLSS) [-20.3 
      (-11 to -26) vs. -22 (-17.8 to -30.4)%, p < 0.0001], PLSS rate [-1.19 +/- 0.21 vs. 
      -1.3 +/- 0.25 s(-1), p = 0.0005], longitudinal strain rate in early diastole [1.7 
      (0.99-2.95) vs. 2 (1.08-3.00) s(-1), p = 0.0034], peak radial systolic strain 
      [33.09 +/- 8.6 vs. 44.36 +/- 8.72%, p < 0.0001], peak radial systolic strain rate 
      [1.98 +/- 0.53 vs. 2.49 +/- 0.68 s(-1), p < 0.0001], and radial strain rate in early 
      diastole [-2.31 +/- 0.88 vs. -2.75 +/- 0.97 s(-1), p = 0.02]. Peak circumferential 
      systolic strain [-23.67 +/- 3.46 vs. -24.6 +/- 2.86%, p = 0.43] and circumferential 
      strain in early diastole [0.37 +/- 0.17 vs. 0.41 +/- 0.15, p = 0.27] were similar 
      between patients and controls, although peak circumferential systolic strain rate 
      [-1.5 +/- 0.3 vs. -1.6 +/- 0.3 s(-1), p = 0.036] was reduced in c-SLE. Further 
      analysis of patients revealed a negative correlation between LV PLSS and 
      SLEDAI-2K (r = -0.52, p < 0.0001), and also between LV PLSS and the number of 
      CRFs per patient (r = -0.32, p = 0.024). CONCLUSIONS: 2DST echocardiography has 
      identified subclinical LV deformation impairment in c-SLE patients. Disease 
      activity and cumulative exposure to CRFs contribute to myocardial compromise.
FAU - Leal, G N
AU  - Leal GN
AD  - a Department of Radiology, Children's Institute, Hospital das Clinicas , Sao 
      Paulo University Medical School.
FAU - Silva, K F
AU  - Silva KF
AD  - a Department of Radiology, Children's Institute, Hospital das Clinicas , Sao 
      Paulo University Medical School.
FAU - Lianza, A C
AU  - Lianza AC
AD  - a Department of Radiology, Children's Institute, Hospital das Clinicas , Sao 
      Paulo University Medical School.
FAU - Giacomin, M F
AU  - Giacomin MF
AD  - b Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculty of 
      Medicine , University of Sao Paulo.
FAU - Andrade, J L
AU  - Andrade JL
AD  - c Institute of Radiology, Hospital das Clinicas , Sao Paulo University Medical 
      School.
FAU - Kozu, K
AU  - Kozu K
AD  - b Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculty of 
      Medicine , University of Sao Paulo.
FAU - Bonfa, E
AU  - Bonfa E
AD  - d Department of Rheumatology, Faculty of Medicine , University of Sao Paulo , Sao 
      Paulo , Brazil.
FAU - Silva, C A
AU  - Silva CA
AD  - b Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculty of 
      Medicine , University of Sao Paulo.
LA  - eng
PT  - Journal Article
DEP - 20150831
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
SB  - IM
MH  - Adolescent
MH  - *Asymptomatic Diseases
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*diagnostic imaging/epidemiology
MH  - Male
MH  - Risk Factors
MH  - *Stroke Volume
MH  - Systole
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/epidemiology
MH  - Young Adult
EDAT- 2015/09/02 06:00
MHDA- 2016/08/16 06:00
CRDT- 2015/09/02 06:00
PHST- 2015/09/02 06:00 [entrez]
PHST- 2015/09/02 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
AID - 10.3109/03009742.2015.1063686 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 2016;45(3):202-9. doi: 10.3109/03009742.2015.1063686. Epub 
      2015 Aug 31.