PMID- 26327142
OWN - NLM
STAT- MEDLINE
DCOM- 20160301
LR  - 20161125
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 606
DP  - 2015 Oct 8
TI  - Three-dimensional alteration of cervical anterior spinal artery and anterior 
      radicular artery in rat model of chronic spinal cord compression by micro-CT.
PG  - 106-12
LID - S0304-3940(15)30120-8 [pii]
LID - 10.1016/j.neulet.2015.08.050 [doi]
AB  - OBJECTIVE: To investigate the spatial and temporal changes of anterior spinal 
      artery (ASA) and anterior radicular artery (ARA) of chronic compressive spinal 
      cord injury on rat model by three-dimensional micro-CT. METHODS: 48 rats were 
      divided into two groups: sham control group (n=24) and compressive spinal cord 
      injury group (n=24). A C6 semi-laminectomy was performed in the sham control 
      group, while a water-absorbable polyurethane polymer was implanted into C6 
      epidural space in the compression group. The Basso Beattie Bresnahan (BBB) score 
      and somatosensory evoked potentials (SEP) were used to evaluate neurological 
      function. Micro-CT scanning was used to investigate the change of ASA and ARA 
      after perfusion at the 1th (n=6), 28th (n=6), 42th (n=6) and 70th (n=6) day of 
      post operation. The diameter, angle-off and vascular index (VI) was measured by 
      3D micro-CT. RESULTS: In comparison with sham control, BBB score have a 
      significant reduction at the 28th day (p<0.05) and abnormal SEP have a 
      significant severity at the 28th day (p<0.05). Both of them have a significant 
      improvement at the 70th day compared with that of the 28th day (p<0.05). VI shows 
      the amount of microvessels reduced at the 28th day (p<0.05) and increased at the 
      70th day (p<0.05). The diameter and angle-off of ASA and ARA also changed 
      significantly at the 28th, 42th, 70th day (p<0.05). CONCLUSION: There was a 
      significant alteration of cervical anterior spinal artery and anterior radicular 
      artery after chronic cervical spinal cord compression. Alteration of ASA and ARA 
      may affect the vascular density of spinal cord and play an important role in 
      neural functional change of chronic cervical spinal cord compression through 3D 
      micro-CT.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Cheng, Xing
AU  - Cheng X
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou 510080, PR China.
FAU - Long, HouQing
AU  - Long H
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou 510080, PR China. Electronic address: houqinglong@163.com.
FAU - Chen, WenLi
AU  - Chen W
AD  - Department of neurosurgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou 510080, PR China.
FAU - Xu, JingHui
AU  - Xu J
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou 510080, PR China.
FAU - Huang, YangLiang
AU  - Huang Y
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou 510080, PR China.
FAU - Li, FoBao
AU  - Li F
AD  - Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou 510080, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150905
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Animals
MH  - Cervical Vertebrae/*blood supply/diagnostic imaging
MH  - Evoked Potentials, Somatosensory
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/*blood supply/diagnostic imaging
MH  - Spinal Cord Compression/diagnostic imaging/*pathology/physiopathology
MH  - Tomography, X-Ray Computed
MH  - Vertebral Artery/diagnostic imaging/pathology
OTO - NOTNLM
OT  - 3D micro-CT
OT  - Anterior radicular artery
OT  - Anterior spinal artery
OT  - Chronic spinal cord compression
OT  - Neurological function
EDAT- 2015/09/04 06:00
MHDA- 2016/03/02 06:00
CRDT- 2015/09/02 06:00
PHST- 2015/07/31 00:00 [received]
PHST- 2015/08/26 00:00 [accepted]
PHST- 2015/09/02 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - S0304-3940(15)30120-8 [pii]
AID - 10.1016/j.neulet.2015.08.050 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Oct 8;606:106-12. doi: 10.1016/j.neulet.2015.08.050. Epub 
      2015 Sep 5.