PMID- 26327809
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20181113
IS  - 1449-2288 (Electronic)
IS  - 1449-2288 (Linking)
VI  - 11
IP  - 10
DP  - 2015
TI  - Beneficial Effects of Highly Palatable Food on the Behavioral and Neural 
      Adversities induced by Early Life Stress Experience in Female Rats.
PG  - 1150-9
LID - 10.7150/ijbs.12044 [doi]
AB  - This study examined the effects of highly palatable food during adolescence on 
      the psycho-emotional and neural disturbances caused by early life stress 
      experience in female rats. Female Sprague-Dawley pups were separated from dam for 
      3 h daily during the first two weeks of birth (MS) or left undisturbed (NH). Half 
      of MS females received free access to chocolate cookies in addition to ad libitum 
      chow from postnatal day 28. Pups were subjected to the behavioral tests during 
      young adulthood. The plasma corticosterone response to acute stress, DeltaFosB and 
      brain-derived neurotrophic factor (BDNF) levels in the brain regions were 
      analyzed. Total caloric intake and body weight gain during the whole experimental 
      period did not differ among the experimental groups. Cookie access during 
      adolescence and youth improved anxiety-/depression-like behaviors by MS 
      experience. DeltaFosB expression was decreased, but BDNF was increased in the nucleus 
      accumbens of MS females, and DeltaFosB expression was normalized and BDNF was further 
      increased following cookie access. Corticosterone response to acute stress was 
      blunted by MS experience and cookie access did not improve it. Results suggest 
      that cookie access during adolescence improves the psycho-emotional disturbances 
      of MS females, and DeltaFosB and/or BDNF expression in the nucleus accumbens may play 
      a role in its underlying neural mechanisms.
FAU - Kim, Jin Young
AU  - Kim JY
AD  - 1. Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul 
      National University School of Dentistry, Seoul, 110-768, Korea.
FAU - Lee, Jong-Ho
AU  - Lee JH
AD  - 1. Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul 
      National University School of Dentistry, Seoul, 110-768, Korea.
FAU - Kim, Doyun
AU  - Kim D
AD  - 1. Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul 
      National University School of Dentistry, Seoul, 110-768, Korea ; 2. Department of 
      Brain Science, Daegu Gyeongbuk Institute of Science & Technology, Dae Gu, 
      711-873, Korea.
FAU - Kim, Soung-Min
AU  - Kim SM
AD  - 1. Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul 
      National University School of Dentistry, Seoul, 110-768, Korea.
FAU - Koo, JaeHyung
AU  - Koo J
AD  - 2. Department of Brain Science, Daegu Gyeongbuk Institute of Science & 
      Technology, Dae Gu, 711-873, Korea.
FAU - Jahng, Jeong Won
AU  - Jahng JW
AD  - 1. Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul 
      National University School of Dentistry, Seoul, 110-768, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150801
PL  - Australia
TA  - Int J Biol Sci
JT  - International journal of biological sciences
JID - 101235568
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fosb protein, rat)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Anxiety/diet therapy
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/blood
MH  - Depression/diet therapy
MH  - Feeding Behavior/*psychology
MH  - Female
MH  - Food
MH  - Nucleus Accumbens/*metabolism
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - *Stress, Psychological
MH  - Weight Gain
PMC - PMC4551751
OTO - NOTNLM
OT  - Early life stress
OT  - Female
OT  - Highly palatable food
OT  - Nucleus accumbens
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2015/09/04 06:00
MHDA- 2016/06/28 06:00
PMCR- 2015/01/01
CRDT- 2015/09/02 06:00
PHST- 2015/03/04 00:00 [received]
PHST- 2015/07/13 00:00 [accepted]
PHST- 2015/09/02 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - ijbsv11p1150 [pii]
AID - 10.7150/ijbs.12044 [doi]
PST - epublish
SO  - Int J Biol Sci. 2015 Aug 1;11(10):1150-9. doi: 10.7150/ijbs.12044. eCollection 
      2015.