PMID- 26329428
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20230322
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Linking)
VI  - 9
IP  - 2
DP  - 2016 Mar
TI  - The lymph nodes draining the small intestine and colon are anatomically separate 
      and immunologically distinct.
PG  - 468-78
LID - 10.1038/mi.2015.77 [doi]
AB  - Dendritic cells (DCs) in the small intestine (SI) and colon are fundamental to 
      direct intestinal immune responses; they migrate to the mesenteric lymph nodes 
      (MLNs) and prime T cells. We demonstrate anatomical segregation of lymphatic 
      drainage from the intestine, specifically that DCs from the SI and colon migrate 
      to different nodes within the MLN, here called the sMLN and cMLN. As a 
      consequence, different frequencies of DC subsets observed in the SI and colon are 
      reflected among the DCs in the sMLN and cMLN. Consistent with the SI's function 
      in absorbing food, fed antigen is presented in the sMLN, but not in the cMLN. 
      Furthermore, the levels of expression of CCR9 and alpha4beta7 are increased on T cells 
      in the sMLN compared with the cMLN. DCs from the cMLN and colon are unable to 
      metabolize vitamin A to retinoic acid (RA); thus, DCs may contribute to the 
      differential expression of tissue homing markers observed in the sMLN and cMLN. 
      In summary, the sMLN and cMLN, and the DCs that migrate to these LNs are 
      anatomically and immunologically separate. This segregation allows immune 
      responses in the SI and colon to be controlled independently.
FAU - Houston, S A
AU  - Houston SA
AD  - Centre for Immunobiology, Institute for Infection, Immunity and Inflammation, 
      College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, 
      UK.
FAU - Cerovic, V
AU  - Cerovic V
AD  - Centre for Immunobiology, Institute for Infection, Immunity and Inflammation, 
      College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, 
      UK.
FAU - Thomson, C
AU  - Thomson C
AD  - Centre for Immunobiology, Institute for Infection, Immunity and Inflammation, 
      College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, 
      UK.
FAU - Brewer, J
AU  - Brewer J
AD  - Centre for Immunobiology, Institute for Infection, Immunity and Inflammation, 
      College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, 
      UK.
FAU - Mowat, A M
AU  - Mowat AM
AD  - Centre for Immunobiology, Institute for Infection, Immunity and Inflammation, 
      College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, 
      UK.
FAU - Milling, S
AU  - Milling S
AD  - Centre for Immunobiology, Institute for Infection, Immunity and Inflammation, 
      College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, 
      UK.
LA  - eng
GR  - MR/K021095/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/L000598/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/N023625/1/MRC_/Medical Research Council/United Kingdom
GR  - BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150902
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
RN  - 0 (CC chemokine receptor 9)
RN  - 0 (Integrins)
RN  - 0 (Receptors, CCR)
RN  - 0 (integrin alpha4beta7)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Lineage/immunology
MH  - Cell Movement
MH  - Cell Tracking
MH  - Colon/*cytology/immunology
MH  - Dendritic Cells/*cytology/immunology
MH  - Flow Cytometry
MH  - Gene Expression Regulation
MH  - Immunity, Mucosal
MH  - Immunophenotyping
MH  - Integrins/genetics/immunology
MH  - Intestinal Mucosa/*cytology/immunology
MH  - Intestine, Small/*cytology/immunology
MH  - Lymph Nodes/*cytology/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptors, CCR/genetics/immunology
MH  - Signal Transduction
MH  - T-Lymphocytes/*cytology/immunology
EDAT- 2015/09/04 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/09/03 06:00
PHST- 2015/01/30 00:00 [received]
PHST- 2015/07/19 00:00 [accepted]
PHST- 2015/09/03 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1933-0219(22)00875-3 [pii]
AID - 10.1038/mi.2015.77 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2016 Mar;9(2):468-78. doi: 10.1038/mi.2015.77. Epub 2015 Sep 2.