PMID- 26330392
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1932-2968 (Electronic)
IS  - 1932-2968 (Linking)
VI  - 10
IP  - 2
DP  - 2015 Aug 31
TI  - Structural Changes by Spectral Domain Optical Coherence Tomography in Patients 
      With Type 1 Diabetes Mellitus.
PG  - 271-6
LID - 10.1177/1932296815603371 [doi]
AB  - BACKGROUND: With a possible increase in the prevalence of type 1 diabetes 
      mellitus (DM1), the pediatric patient population is expected to be at risk for 
      other health care complications. Current imaging modalities, such as the spectral 
      domain optical coherence tomography (SD-OCT), that allow micron resolution 
      imaging of the retina have become a standard of care for showing morphological 
      changes seen in the retina in adults with diabetes. Such pathologies can be 
      associated with known risk factors such as poor glycemic control (HbA1C) and body 
      mass index (BMI). METHODS: A comprehensive screening was performed in subjects 
      with DM1 including nonmydriatic fundus imaging (Canon, CR2 Plus-AF with EOS-60D, 
      Tokyo, Japan) and SD-OCT imaging (Optovue, iVue, Fremont, CA). SD-OCT scans were 
      acquired showing macular thickness (MT) and thickness of the parafoveal regions 
      and the perifoveal regions. Associations of macular, paramacular, and perimacular 
      thickness were analyzed as a function of HbA1C and BMI by simple linear 
      regressions. RESULTS: SD-OCT changes were analyzed in eyes of subjects with DM1 
      and normal fundus appearance by color imaging. Linear regression analysis of 
      thickness of macula right eye (RT), paramacula RT, paramacula left eye (LT), 
      perimacula LT with BMI were statistically significant (P < .05). HbA1C >7.5% was 
      also found statistically significant in the macula RT, paramacula RT, paramacula 
      LT, perimacula RT, and perimacula LT. A general trend of thickening of the 
      macula, paramacula, and perimacula was observed with increasing HbA1C (>7.5%) and 
      increasing BMI; however, no statistical significance was found. CONCLUSIONS: 
      SD-OCT with retinal imaging was feasible in young individuals with DM1 and 
      revealed ultrastructural macular and perimacular changes prior to manifest 
      clinical disease.
CI  - (c) 2015 Diabetes Technology Society.
FAU - Mendez, Nicole
AU  - Mendez N
AD  - Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical 
      School, Newark, NJ, USA.
FAU - Kommana, Sumana S
AU  - Kommana SS
AD  - Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical 
      School, Newark, NJ, USA.
FAU - Szirth, Bernard
AU  - Szirth B
AD  - Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical 
      School, Newark, NJ, USA.
FAU - Khouri, Albert S
AU  - Khouri AS
AD  - Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical 
      School, Newark, NJ, USA khourias@njms.rutgers.edu.
LA  - eng
PT  - Journal Article
DEP - 20150831
PL  - United States
TA  - J Diabetes Sci Technol
JT  - Journal of diabetes science and technology
JID - 101306166
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*diagnostic imaging
MH  - Diabetic Retinopathy/*diagnostic imaging
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - Retina/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
PMC - PMC4773956
OTO - NOTNLM
OT  - diabetes
OT  - imaging methods
OT  - macula/fovea
OT  - optical coherence tomography
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2015/09/04 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/08/31
CRDT- 2015/09/03 06:00
PHST- 2015/09/03 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/08/31 00:00 [pmc-release]
AID - 1932296815603371 [pii]
AID - 10.1177_1932296815603371 [pii]
AID - 10.1177/1932296815603371 [doi]
PST - epublish
SO  - J Diabetes Sci Technol. 2015 Aug 31;10(2):271-6. doi: 10.1177/1932296815603371.