PMID- 26330656
OWN - NLM
STAT- MEDLINE
DCOM- 20160607
LR  - 20181113
IS  - 0065-7778 (Print)
IS  - 0065-7778 (Linking)
VI  - 126
DP  - 2015
TI  - Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions.
PG  - 9-19
AB  - Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins 
      which include nerve growth factor, neurotrophin 3, and neurotrophin 4. Studies 
      over the last three decades have identified mature BDNF as a key regulator of 
      neuronal differentiation, structure, and function; actions mediated by the TrkB 
      receptor. More recently identified isoforms which are translated from the bdnf 
      gene, including the uncleaved precursor, pro-BDNF, and the cleaved prodomain, 
      have been found to elicit opposing functions in neurons through the activation of 
      distinct receptors. This work emphasizes the critical roles for all three 
      isoforms of BDNF in modulating neuronal activity that impact complex human 
      behaviors including memory, anxiety, depression, and hyperphagia.
FAU - Hempstead, Barbara L
AU  - Hempstead BL
AD  - New York, New York.
LA  - eng
GR  - R01 NS030687/NS/NINDS NIH HHS/United States
GR  - R01 NS064114/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Trans Am Clin Climatol Assoc
JT  - Transactions of the American Clinical and Climatological Association
JID - 7507559
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ligands)
RN  - 0 (Protein Isoforms)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/chemistry/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Ligands
MH  - Polymorphism, Genetic
MH  - Protein Conformation
MH  - Protein Isoforms
MH  - Receptor, trkB/*metabolism
MH  - *Signal Transduction
MH  - Structure-Activity Relationship
PMC - PMC4530710
COIS- Potential Conflicts of Interest: None disclosed.
EDAT- 2015/09/04 06:00
MHDA- 2016/06/09 06:00
PMCR- 2015/01/01
CRDT- 2015/09/03 06:00
PHST- 2015/09/03 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
PST - ppublish
SO  - Trans Am Clin Climatol Assoc. 2015;126:9-19.