PMID- 26330923
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150902
LR  - 20201001
IS  - 1976-8710 (Print)
IS  - 2005-0720 (Electronic)
IS  - 1976-8710 (Linking)
VI  - 8
IP  - 3
DP  - 2015 Sep
TI  - A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in 
      Laryngeal Carcinoma.
PG  - 268-74
LID - 10.3342/ceo.2015.8.3.268 [doi]
AB  - OBJECTIVES: In numerous malignancies, angiogenin (ANG) and Maspin are important 
      proangiogenic and antiangiogenic regulators, respectively. The aim of this study 
      was to identify potential relationships between the biological roles of these two 
      proteins in laryngeal squamous cell carcinoma (LSCC). METHODS: 
      Immunohistochemical staining for ANG and Maspin was performed on specimens from 
      76 consecutive LSCC patients treated with surgery alone, considering the 
      subcellular pattern of Maspin expression. Univariate and multivariate statistical 
      models were used for prognostic purposes. RESULTS: On univariate analysis, a 
      different level of ANG expression was seen for patients stratified by subcellular 
      Maspin expression pattern: the mean ANG expression was higher in cases with a 
      nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). 
      Disease-free survival (DFS; in months) differed significantly when patients were 
      stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear 
      (i.e., it was cytoplasmic or there was none) had a significantly higher 
      recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear 
      Maspin pattern. The mean ANG expression was significantly higher in cases with 
      loco-regional recurrent disease (P=0.007); and patients with an ANG expression 
      >/=5.0% had a significantly shorter DFS than those with an ANG expression <5.0% 
      (P=0.007). On multivariate analysis, ANG expression >/=5.0% was a significant, 
      independent, negative prognostic factor in terms of DFS (P=0.041). CONCLUSION: 
      Our results support the hypothesis that a higher ANG expression is associated 
      with a nonnuclear Maspin expression pattern in patients with LSCC. Further 
      studies are needed to clarify the relationship between the ANG and Maspin 
      pathways, and their potential diagnostic and therapeutic role in LSCC.
FAU - Lovato, Andrea
AU  - Lovato A
AD  - Department of Neurosciences, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Lionello, Marco
AU  - Lionello M
AD  - Department of Neurosciences, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Staffieri, Alberto
AU  - Staffieri A
AD  - Department of Neurosciences, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Blandamura, Stella
AU  - Blandamura S
AD  - Department of Medicine, University of Padova, Padova, Italy.
FAU - Tealdo, Giulia
AU  - Tealdo G
AD  - Department of Neurosciences, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Giacomelli, Luciano
AU  - Giacomelli L
AD  - Department of Medicine, University of Padova, Padova, Italy.
FAU - Staffieri, Claudia
AU  - Staffieri C
AD  - Department of Neurosciences, Otolaryngology Section, Treviso Hospital Branch, 
      University of Padova, Treviso, Italy.
FAU - Marioni, Gino
AU  - Marioni G
AD  - Department of Neurosciences, Otolaryngology Section, University of Padova, 
      Padova, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150813
PL  - Korea (South)
TA  - Clin Exp Otorhinolaryngol
JT  - Clinical and experimental otorhinolaryngology
JID - 101474010
PMC - PMC4553359
OTO - NOTNLM
OT  - Angiogenin
OT  - Intracellular Space
OT  - Laryngeal Neoplasms
OT  - Prognosis
OT  - SERPIN-B5
COIS- CONFLICT OF INTEREST: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2015/09/04 06:00
MHDA- 2015/09/04 06:01
PMCR- 2015/09/01
CRDT- 2015/09/03 06:00
PHST- 2013/12/19 00:00 [received]
PHST- 2014/03/14 00:00 [revised]
PHST- 2014/03/23 00:00 [accepted]
PHST- 2015/09/03 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2015/09/04 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 10.3342/ceo.2015.8.3.268 [doi]
PST - ppublish
SO  - Clin Exp Otorhinolaryngol. 2015 Sep;8(3):268-74. doi: 10.3342/ceo.2015.8.3.268. 
      Epub 2015 Aug 13.