PMID- 26331133
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150902
LR  - 20201001
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 11
IP  - 4
DP  - 2015 Aug
TI  - Treadmill exercise alleviates stress-induced impairment of social interaction 
      through 5-hydroxytryptamine 1A receptor activation in rats.
PG  - 192-7
LID - 10.12965/jer.150225 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) and its receptors tyrosine kinase B 
      (trkB), and cyclic adenosine monophosphate response element binding protein 
      (CREB) have been suggested as the neurobiological risk factors causing depressive 
      disorder. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the 
      pathogenesis of depression. We in-vestigated the effect of treadmill exercise on 
      social interaction in relation with BDNF and 5-HT expressions following stress in 
      rats. Stress was induced by applying inescapable 0.2 mA electric foot shock to 
      the rats for 7 days. The rats in the exercise groups were forced to run on a 
      motorized treadmill for 30 min once a day for 4 weeks. Social interaction test 
      and western blot for BDNF, TrkB, pCREB, and 5-HT1A in the hippocampus were 
      performed. The results indicate that the spend time with unfamiliar partner was 
      decreased by stress, in contrast, treadmill exercise increased the spending time 
      in the stress-induced rats. Expressions of BDNF, TrkB, and pCREB were decreased 
      by stress, in contrast, treadmill exercise enhanced expressions of BDNF, TrkB, 
      and pCREB in the stress-induced rats. In addition, 5-HT1A receptor expression was 
      de-creased by stress, in contrast, treadmill exercise enhanced 5-HT1A expression 
      in the stress-induced rats. In the present study, treadmill exercise alleviated 
      stress-induced social interaction impairment through enhancing hippocampal 
      plasticity and serotonergic function in the hippocampus. These effects of 
      treadmill exercise are achieved through 5-HT1A receptor activation.
FAU - Kim, Tae-Woon
AU  - Kim TW
AD  - Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea.
FAU - Lim, Baek-Vin
AU  - Lim BV
AD  - Department of Exercise Prescription, Division of Leisure & Sports Science, 
      Dongseo University, Busan, Korea.
FAU - Kim, Kijeong
AU  - Kim K
AD  - Department of Exercise & Sport Science, College of Natural Sciences, University 
      of Ulsan, Ulsan, Korea.
FAU - Seo, Jin-Hee
AU  - Seo JH
AD  - Division of Sports Science, Baekseok University, Cheonan, Korea.
FAU - Kim, Chang-Ju
AU  - Kim CJ
AD  - Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20150830
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC4548675
OTO - NOTNLM
OT  - 5-hydroxytryptamine 1A receptor
OT  - Brain-derived neurotrophic factor
OT  - CREP
OT  - Social interaction
OT  - Treadmill exercise
OT  - Tyrosine kinase B
EDAT- 2015/09/04 06:00
MHDA- 2015/09/04 06:01
PMCR- 2015/08/30
CRDT- 2015/09/03 06:00
PHST- 2015/07/13 00:00 [received]
PHST- 2015/08/17 00:00 [accepted]
PHST- 2015/09/03 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2015/09/04 06:01 [medline]
PHST- 2015/08/30 00:00 [pmc-release]
AID - jer-11-4-192 [pii]
AID - 10.12965/jer.150225 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2015 Aug 30;11(4):192-7. doi: 10.12965/jer.150225. eCollection 
      2015 Aug.