PMID- 26331311
OWN - NLM
STAT- MEDLINE
DCOM- 20160902
LR  - 20181202
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Print)
IS  - 1064-1963 (Linking)
VI  - 38
IP  - 1
DP  - 2016
TI  - Combination therapy with nifedipine GITS 60 mg: subanalysis of a prospective, 
      12-week observational study (AdADOSE).
PG  - 71-80
LID - 10.3109/10641963.2015.1060986 [doi]
AB  - BACKGROUND: AdADOSE was a 12-week, international, observational study conducted 
      in the Middle East and Russia where patients received nifedipine gastrointestinal 
      therapeutic system (GITS) at a daily dose of 30, 60, or 90 mg as part of an 
      antihypertensive combination therapy. This subgroup analysis of the AdADOSE study 
      assesses the efficacy and tolerability of nifedipine GITS combination therapy 
      when used specifically at the 60-mg strength. METHODS: Patients with hypertension 
      who received a daily nifedipine GITS dose of 60 mg, either at constant dose 
      (n = 686) or up-titrated from 30 mg (n = 392), were analyzed. Target blood 
      pressure (BP) was <140/90 mmHg (or <130/80 mmHg for those at high/very high 
      cardiovascular risk). RESULTS: Following nifedipine GITS combination therapy, 
      target BP was achieved by 33.7% patients in the 60 mg group (previously 
      untreated, 42.5%; previously treated, 32.0%) and 32.4% patients in the 30-60 mg 
      group (previously untreated, 45.2%; previously treated, 30.7%). Mean systolic 
      BP/diastolic BP changes were -40.3/-20.7 mmHg and -35.6/-18.5 mmHg, respectively, 
      and were similar regardless of previous antihypertensive treatment or the number 
      of concomitant diseases. Incidences of drug-related adverse events (AEs) were low 
      (3.2%, 60 mg; 2.0%, 30-60 mg group), few patients discontinued because of AEs 
      (0.6% and 1.0%, respectively), and there were no serious AEs. CONCLUSION: 
      Combination therapy with nifedipine GITS 60 mg in a real-life observational 
      setting was effective and well tolerated in hypertensive patients, with low rates 
      of treatment-related AEs.
FAU - Motaweih, Ahmed K
AU  - Motaweih AK
AD  - a Cardiovascular Medicine Department, Faculty of Medicine, Azhar University , 
      Giza , Egypt .
FAU - Usova, Elena
AU  - Usova E
AD  - b Outpatient Department , Clinical Hospital 122 , Saint Petersburg , Russia .
FAU - Hussain, Wajid
AU  - Hussain W
AD  - c Department of Cardiology , Baqai Institute of Cardiovascular Diseases , Karachi 
      , Pakistan .
FAU - Dello, Ziad
AU  - Dello Z
AD  - d Department of Cardiology , Dallah Hospital , Riyadh , Saudi Arabia , and.
FAU - Petri, Thomas
AU  - Petri T
AD  - e Global Medical Affairs Primary Care, Bayer Pharma AG , Berlin , Germany.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150902
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - I9ZF7L6G2L (Nifedipine)
SB  - IM
MH  - Adult
MH  - Antihypertensive Agents/administration & dosage/adverse effects
MH  - Blood Pressure/*drug effects
MH  - Blood Pressure Determination
MH  - Delayed-Action Preparations/administration & dosage/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Monitoring
MH  - Drug Therapy, Combination/methods
MH  - Female
MH  - Humans
MH  - Hypertension/diagnosis/*drug therapy/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Middle East
MH  - *Nifedipine/administration & dosage/adverse effects
MH  - Prospective Studies
MH  - Russia
MH  - Treatment Outcome
PMC - PMC4720040
OTO - NOTNLM
OT  - AdADOSE
OT  - cardiovascular
OT  - hypertension
OT  - nifedipine GITS
OT  - observational study
EDAT- 2015/09/04 06:00
MHDA- 2016/09/03 06:00
PMCR- 2016/01/20
CRDT- 2015/09/03 06:00
PHST- 2015/09/03 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/09/03 06:00 [medline]
PHST- 2016/01/20 00:00 [pmc-release]
AID - 1060986 [pii]
AID - 10.3109/10641963.2015.1060986 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2016;38(1):71-80. doi: 10.3109/10641963.2015.1060986. Epub 
      2015 Sep 2.