PMID- 26332651
OWN - NLM
STAT- MEDLINE
DCOM- 20160902
LR  - 20220330
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 65
IP  - 11
DP  - 2015 Nov
TI  - Clinical implication of human leukocyte antigen (HLA)-F expression in breast 
      cancer.
PG  - 569-74
LID - 10.1111/pin.12343 [doi]
AB  - Human leukocyte antigen (HLA)-F is one of the non-classical HLA class I molecules 
      that protects the fetus in pregnancy. HLA-F expression was immunohistochemically 
      examined and the association between clinical parameters and HLA-F expression was 
      analyzed. Cancerous HLA-F and stromal HLA-F-positive infiltrating cells were 
      detected in 91 (40.0%) and 186 (81.6%) cases, respectively. HLA-F positivity in 
      cancer cells was significantly associated with tumor size (P < 0.05). There was a 
      weak correlation between HLA-F positivity of cancer cells and HLA-F positive 
      infiltrative cells (P < 0.01, r = 0.11). HLA-F positivity did not affect 
      patients' survival in 209 breast cancer. However, confined to stage II breast 
      cancer, the HLA-F positive group showed significantly poorer outcomes than the 
      HLA-F negative group (P < 0.05). The present study provides the first evidence 
      that HLA-F positivity in breast carcinoma affects clinicopathological factors and 
      could be selected as a prognostic marker for limited clinical stage.
CI  - (c) 2015 The Authors. Pathology International published by Japanese Society of 
      Pathology and Wiley Publishing Asia Pty Ltd.
FAU - Harada, Aya
AU  - Harada A
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
FAU - Ishigami, Sumiya
AU  - Ishigami S
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
FAU - Kijima, Yuko
AU  - Kijima Y
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
FAU - Nakajo, Akihiro
AU  - Nakajo A
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
FAU - Arigami, Takaaki
AU  - Arigami T
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
FAU - Kurahara, Hiroshi
AU  - Kurahara H
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
FAU - Kita, Yoshiaki
AU  - Kita Y
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
FAU - Yoshinaka, Heiji
AU  - Yoshinaka H
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
FAU - Natsugoe, Shoji
AU  - Natsugoe S
AD  - Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima 
      University School of Medicine, Kagoshima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150902
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA-F antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/analysis/immunology
MH  - Breast Neoplasms/diagnosis/immunology/*metabolism
MH  - Female
MH  - Histocompatibility Antigens Class I/immunology/*metabolism
MH  - Humans
MH  - Leukocytes/*cytology/immunology
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Prognosis
OTO - NOTNLM
OT  - HLA-F
OT  - breast cancer
OT  - clinical stage
OT  - tumor infiltrating cells
EDAT- 2015/09/04 06:00
MHDA- 2016/09/03 06:00
CRDT- 2015/09/03 06:00
PHST- 2014/12/16 00:00 [received]
PHST- 2015/07/09 00:00 [accepted]
PHST- 2015/09/03 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/09/03 06:00 [medline]
AID - 10.1111/pin.12343 [doi]
PST - ppublish
SO  - Pathol Int. 2015 Nov;65(11):569-74. doi: 10.1111/pin.12343. Epub 2015 Sep 2.