PMID- 26333063 OWN - NLM STAT- MEDLINE DCOM- 20161019 LR - 20161230 IS - 1365-2222 (Electronic) IS - 0954-7894 (Linking) VI - 46 IP - 2 DP - 2016 Feb TI - Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age. PG - 329-36 LID - 10.1111/cea.12631 [doi] AB - BACKGROUND: Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring. METHODS: In a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE >/= 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414). RESULTS: There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%). CONCLUSION AND CLINICAL RELEVANCE: Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life. CI - (c) 2015 John Wiley & Sons Ltd. FAU - Hansen, S AU - Hansen S AD - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. FAU - Strom, M AU - Strom M AD - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. FAU - Olsen, S F AU - Olsen SF AD - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Dahl, R AU - Dahl R AD - The Allergy Centre, Odense University Hospital, Odense, Denmark. AD - Department of Pulmonary Medicine and Allergy, Aarhus University Hospital, Aarhus, Denmark. FAU - Hoffmann, H J AU - Hoffmann HJ AD - Department of Pulmonary Medicine and Allergy, Aarhus University Hospital, Aarhus, Denmark. FAU - Granstrom, C AU - Granstrom C AD - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. FAU - Rytter, D AU - Rytter D AD - Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark. FAU - Bech, B H AU - Bech BH AD - Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark. FAU - Linneberg, A AU - Linneberg A AD - Research Centre for Prevention and Health, the Capital Region of Denmark, Copenhagen, Denmark. AD - Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup, Denmark, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Maslova, E AU - Maslova E AD - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. FAU - Kiviranta, H AU - Kiviranta H AD - Chemicals and Health Unit, National Institute for Health and Welfare, Kuopio, Finland. FAU - Rantakokko, P AU - Rantakokko P AD - Chemicals and Health Unit, National Institute for Health and Welfare, Kuopio, Finland. FAU - Halldorsson, T I AU - Halldorsson TI AD - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. AD - Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. AD - Unit for Nutrition Research, Landspitali University Hospital, Reykjavik, Iceland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Clin Exp Allergy JT - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JID - 8906443 RN - 0 (Environmental Pollutants) RN - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) RN - 4Z87H0LKUY (Hexachlorobenzene) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Chromatography, Gas MH - Dichlorodiphenyl Dichloroethylene/adverse effects MH - Environmental Exposure/adverse effects MH - Environmental Pollutants/*adverse effects MH - Female MH - Follow-Up Studies MH - Hexachlorobenzene/adverse effects MH - Humans MH - Hypersensitivity/*epidemiology MH - Male MH - Mass Spectrometry MH - Maternal Exposure/*adverse effects MH - Polychlorinated Biphenyls/adverse effects MH - Pregnancy MH - Prenatal Exposure Delayed Effects/*epidemiology MH - Pulmonary Disease, Chronic Obstructive/*epidemiology MH - Respiratory Function Tests MH - Young Adult OTO - NOTNLM OT - allergic sensitization OT - lung function OT - persistent organic pollutants (POPs) OT - prenatal exposure EDAT- 2015/09/04 06:00 MHDA- 2016/11/12 06:00 CRDT- 2015/09/03 06:00 PHST- 2015/06/05 00:00 [received] PHST- 2015/08/24 00:00 [revised] PHST- 2015/08/25 00:00 [accepted] PHST- 2015/09/03 06:00 [entrez] PHST- 2015/09/04 06:00 [pubmed] PHST- 2016/11/12 06:00 [medline] AID - 10.1111/cea.12631 [doi] PST - ppublish SO - Clin Exp Allergy. 2016 Feb;46(2):329-36. doi: 10.1111/cea.12631.