PMID- 26333706
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150903
LR  - 20220317
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 7
IP  - 6
DP  - 2015 Nov
TI  - Effect of Retinoic Acid in a Mouse Model of Allergic Rhinitis.
PG  - 590-8
LID - 10.4168/aair.2015.7.6.590 [doi]
AB  - PURPOSE: All-trans retinoic acid (ATRA) modulates immune responses by affecting T 
      cells. Several studies have revealed that allergic inflammation of the lower 
      airways is negatively associated with the vitamin A concentration. However, the 
      role of ATRA in allergic inflammation of the upper airways is unclear. We 
      investigated the effects of ATRA in an allergic rhinitis mouse model. METHODS: 
      BALB/c mice except control groups (CON group) were sensitized with and challenged 
      intra-nasally with Dermatophagoides farina (AR group). The ATRA groups were 
      administered ATRA intraperitoneally. The steroid groups were administered steroid 
      intranasally (ST group). Allergic symptoms and the average eosinophil number were 
      counted. Cytokines and transcription factors were measured by Real-Time PCR and 
      Western blotting. Der f-specific immunoglobulin E (IgE) was measured. Flow 
      cytometry results of CD4(+)CD25(+)Foxp3(+) T cells were analyzed. RESULTS: The symptom 
      scores were lower in the ATRA group than in the AR group and higher than in the 
      CON group. The levels of IgE were lower in the ATRA group than in the AR group 
      and higher than in the CON and ST groups. The levels of Foxp3, TGF-beta, and IL-10 
      mRNA, as well as the percentage of CD4(+)CD25(+)Foxp3(+) T cells, were higher in the 
      ATRA group than in theAR group. In the ATRA group the levels of IFN-gamma mRNA were 
      higher, and the levels of GATA-3 and IL-4 mRNA, and ROR-gammat were lower. In Western 
      blotting analyses, the expression patterns of all factors, except Foxp3, showed 
      similar to those of mRNA expression. CONCLUSIONS: ATRA has anti-allergic effects 
      in an allergic rhinitis model, and its underlying mechanisms mainly include the 
      induction of regulatory T cells and the inhibition of Th2 responses.
FAU - Son, Hye Lim
AU  - Son HL
AD  - Department of Otolaryngology-Head and Neck Surgery, St. Vincent's Hospital, 
      College of Medicine, The Catholic University of Korea, Suwon, Korea.
FAU - Park, Hyang Rim
AU  - Park HR
AD  - Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Park, Yong Jin
AU  - Park YJ
AD  - Department of Otolaryngology-Head and Neck Surgery, St. Vincent's Hospital, 
      College of Medicine, The Catholic University of Korea, Suwon, Korea.
FAU - Kim, Soo Whan
AU  - Kim SW
AD  - Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea. 
      kshent@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20150602
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC4605932
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Th17 cells
OT  - Th2 cells
OT  - all-trans retinoic acid
OT  - regulatory T cells
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2015/09/04 06:00
MHDA- 2015/09/04 06:01
PMCR- 2015/11/01
CRDT- 2015/09/04 06:00
PHST- 2014/08/21 00:00 [received]
PHST- 2015/01/28 00:00 [revised]
PHST- 2015/02/25 00:00 [accepted]
PHST- 2015/09/04 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2015/09/04 06:01 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - 201511590 [pii]
AID - 10.4168/aair.2015.7.6.590 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2015 Nov;7(6):590-8. doi: 10.4168/aair.2015.7.6.590. 
      Epub 2015 Jun 2.