PMID- 26334887
OWN - NLM
STAT- MEDLINE
DCOM- 20160211
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 35
DP  - 2015 Sep
TI  - Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility: A Meta-Analysis.
PG  - e0976
LID - 10.1097/MD.0000000000000976 [doi]
LID - e0976
AB  - An increasing number of studies have explored genetic associations between the 
      functionally important polymorphisms in estrogen receptor 1 (ESR1) gene and 
      migraine susceptibility. The previously reported associations have nevertheless 
      been inconsistent.The present work incorporating the published data derived from 
      8 publications was performed to assess the impact of these polymorphisms on 
      incident migraine. Strength of the genetic risk was estimated by means of an odds 
      ratio along with the 95% confidence interval (OR and 95% CI).From the results, we 
      found individuals who harbored the 325-GG genotype, compared with those harboring 
      the CC genotype or CG and CC combined genotypes, had almost 50% greater risk of 
      migraine. The same genetic models showed notable associations in subgroups of 
      Caucasians and migraine with aura (MA). For 594G>A, a moderately increased risk 
      of migraine was seen under AG versus GG. The AA + AG versus GG model, however, 
      showed a borderline association with migraine. Subgroup analyses according to 
      ethnicity and subtype of migraine provided statistical evidence of significantly 
      increased risk of migraine in Caucasians and of a marginal association with MA, 
      respectively. Both 325C>G and 594G>A polymorphisms showed no major effects either 
      in males or in females.Based on the statistical data, we conclude some of the 
      ESR1 gene polymorphisms may have major contributions to the pathogenesis of 
      migraine in Caucasian populations.
FAU - Li, Li
AU  - Li L
AD  - From the Department of Neurology, Chinese PLA General Hospital, Haidan District, 
      Beijing (LL, RL, ZD, XW, SY), and Department of Neurology, General Hospital of 
      Jincheng Anthracite Coal Mining Group Co. Ltd, Jincheng, Shanxi Province, China 
      (LL).
FAU - Liu, Ruozhuo
AU  - Liu R
FAU - Dong, Zhao
AU  - Dong Z
FAU - Wang, Xiaolin
AU  - Wang X
FAU - Yu, Shengyuan
AU  - Yu S
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Migraine Disorders/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
MH  - White People/genetics
PMC - PMC4616512
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2015/09/04 06:00
MHDA- 2016/02/13 06:00
PMCR- 2015/09/04
CRDT- 2015/09/04 06:00
PHST- 2015/09/04 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
PHST- 2015/09/04 00:00 [pmc-release]
AID - 00005792-201509010-00007 [pii]
AID - 10.1097/MD.0000000000000976 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Sep;94(35):e0976. doi: 10.1097/MD.0000000000000976.