PMID- 26334950
OWN - NLM
STAT- MEDLINE
DCOM- 20170117
LR  - 20220310
IS  - 1879-176X (Electronic)
IS  - 0300-5712 (Linking)
VI  - 43
IP  - 11
DP  - 2015 Nov
TI  - Synthesis and characterization of novel halloysite-incorporated adhesive resins.
PG  - 1316-22
LID - S0300-5712(15)30039-7 [pii]
LID - 10.1016/j.jdent.2015.08.014 [doi]
AB  - OBJECTIVE: To investigate the effects of Halloysite(R) aluminosilicate clay 
      nanotubes (HNTs) addition on selected physical, mechanical, and biological 
      properties of experimental adhesive resins. METHODS: Experimental dentin adhesive 
      resins were prepared by mixing Bis-GMA, TEGDMA, HEMA (50/25/25wt.%), and 
      photo-initiators. As-received HNTs were then incorporated into the resin mixture 
      at distinct concentrations: 0 (HNT-free, control), 1, 2.5, 5, 7.5, 10, and 
      20wt.%. The degree of conversion (DC), radiopacity (RP), Knoop hardness (KHN), 
      flexural strength (FS), and cytotoxicity analyses were carried out for each 
      adhesive formulation. The adhesive resin of Adper Scotchbond Multi-Purpose (SBMP) 
      was used as the commercially available reference for both the RP and cytotoxicity 
      tests. Data were statistically analyzed using One-Way ANOVA and Tukey's test 
      (p</=0.05). RESULTS: All adhesives exhibited similar DC (p=0.1931). The RP of 
      adhesives was improved with the addition of up to 5wt.% of HNTs (p<0.001). 
      Adhesives containing 5-10wt.% of HNTs led to greater KHN when compared to the 
      control (p<0.001). The FS was reduced only when 20wt.% of HNTs was added 
      (p</=0.001). None of the prepared adhesives was cytotoxic. CONCLUSION: The 
      incorporation of up to 10wt.% of HNTs into the adhesive resins did not jeopardize 
      the tested physical and biological properties. CLINICAL SIGNIFICANCE: When using 
      HNTs as carriers of drugs/bioactive compounds, the amount of the former added 
      into adhesive resin materials should not exceed 10wt.%; otherwise, a significant 
      reduction in physicomechanical properties may be expected.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Feitosa, Sabrina A
AU  - Feitosa SA
AD  - Department of Biomedical and Applied Sciences, Division of Dental Biomaterials, 
      Indiana University School of Dentistry (IUSD), Indianapolis, IN 46202, USA.
FAU - Munchow, Eliseu A
AU  - Munchow EA
AD  - Department of Biomedical and Applied Sciences, Division of Dental Biomaterials, 
      Indiana University School of Dentistry (IUSD), Indianapolis, IN 46202, USA; 
      Graduate Program in Dentistry, School of Dentistry, Federal University of 
      Pelotas-UFPel, Pelotas, RS 96065-560, Brazil.
FAU - Al-Zain, Afnan O
AU  - Al-Zain AO
AD  - Department of Biomedical and Applied Sciences, Division of Dental Biomaterials, 
      Indiana University School of Dentistry (IUSD), Indianapolis, IN 46202, USA; 
      Division of Operative Dentistry, Department of Conservative Dental Sciences, 
      Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Kamocki, Krzysztof
AU  - Kamocki K
AD  - Department of Biomedical and Applied Sciences, Division of Dental Biomaterials, 
      Indiana University School of Dentistry (IUSD), Indianapolis, IN 46202, USA.
FAU - Platt, Jeffrey A
AU  - Platt JA
AD  - Department of Biomedical and Applied Sciences, Division of Dental Biomaterials, 
      Indiana University School of Dentistry (IUSD), Indianapolis, IN 46202, USA.
FAU - Bottino, Marco C
AU  - Bottino MC
AD  - Department of Biomedical and Applied Sciences, Division of Dental Biomaterials, 
      Indiana University School of Dentistry (IUSD), Indianapolis, IN 46202, USA. 
      Electronic address: mbottino@iu.edu.
LA  - eng
PT  - Journal Article
DEP - 20150831
PL  - England
TA  - J Dent
JT  - Journal of dentistry
JID - 0354422
RN  - 0 (Aluminum Silicates)
RN  - 0 (Dental Cements)
RN  - 0 (Drug Carriers)
RN  - 0 (Resins, Synthetic)
RN  - T1FAD4SS2M (Clay)
SB  - IM
MH  - Aluminum Silicates/*chemistry/toxicity
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Clay
MH  - Dental Cements/*chemistry/toxicity
MH  - Drug Carriers
MH  - Hardness
MH  - Humans
MH  - Materials Testing
MH  - Nanotubes
MH  - Resins, Synthetic/*chemistry/toxicity
OTO - NOTNLM
OT  - Adhesive
OT  - Cytotoxicity
OT  - Drug delivery
OT  - Halloysite
OT  - Nanotubes
OT  - Radiopacity
EDAT- 2015/09/04 06:00
MHDA- 2017/01/18 06:00
CRDT- 2015/09/04 06:00
PHST- 2015/03/23 00:00 [received]
PHST- 2015/08/19 00:00 [revised]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/09/04 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
AID - S0300-5712(15)30039-7 [pii]
AID - 10.1016/j.jdent.2015.08.014 [doi]
PST - ppublish
SO  - J Dent. 2015 Nov;43(11):1316-22. doi: 10.1016/j.jdent.2015.08.014. Epub 2015 Aug 
      31.