PMID- 26335189
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20150904
IS  - 1661-4127 (Electronic)
IS  - 1661-4119 (Linking)
VI  - 22
IP  - 3
DP  - 2015
TI  - A Homeopathic Combination Preparation in the Treatment of Feverish Upper 
      Respiratory Tract Infections: An International Randomized Controlled Trial.
PG  - 163-70
LID - 10.1159/000430762 [doi]
AB  - BACKGROUND: Upper respiratory tract infections (URTI) are very common and 
      associated with considerable healthcare costs. We evaluated the clinical benefit 
      of a homeopathic add-on therapy. PATIENTS AND METHODS: In this randomized 
      controlled multinational clinical trial, patients (age range 1-65 years) with 
      feverish URTI received either on-demand symptomatic standard treatment (ST group: 
      paracetamol, ambroxol, and/or oxymetazoline), or homeopathic medication (IFC 
      group: Influcid(R)) for 7 days plus the same on-demand standard treatment. URTI 
      symptoms were assessed using the Wisconsin Upper Respiratory Symptom Survey-21. 
      Response at day 4, defined as absence of fever and absence or very mild degree of 
      URTI symptoms, was the primary outcome measure. RESULTS: 523 patients (265 IFC 
      group, 258 ST group) were randomized in 12 Ukrainian and 10 German centers. The 
      responder rate on day 4 was 15.4% in the IFC group and 6.7% in the ST group 
      (x0394;IFC-ST = 8.7%, 95% confidence interval 2.9-14.5%). The IFC group used less 
      symptomatic medication, and symptoms were alleviated 1-2 days earlier. 3 and 8 
      adverse events (AEs) in the IFC and ST group, respectively, were assessed as 
      possibly treatment-related; 2 out of the 3 AEs in the IFC group were possibly 
      related to symptomatic therapy, 1 (vomiting) to IFC treatment. CONCLUSION: The 
      homeopathic treatment shortened URTI duration, reduced the use of symptomatic 
      medication, and was well tolerated.
CI  - (c) 2015 S. Karger GmbH, Freiburg.
FAU - Thinesse-Mallwitz, Manuela
AU  - Thinesse-Mallwitz M
AD  - Private Practice, Munich, Germany.
FAU - Maydannik, Vitaly
AU  - Maydannik V
FAU - Keller, Thomas
AU  - Keller T
FAU - Klement, Petra
AU  - Klement P
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150512
PL  - Switzerland
TA  - Forsch Komplementmed
JT  - Forschende Komplementarmedizin (2006)
JID - 101269884
RN  - 0 (Materia Medica)
RN  - 0 (Respiratory System Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Fever/*therapy
MH  - Germany
MH  - Humans
MH  - Male
MH  - Materia Medica/adverse effects/*therapeutic use
MH  - Respiratory System Agents/therapeutic use
MH  - Respiratory Tract Infections/drug therapy/*therapy
MH  - Time
MH  - Treatment Outcome
MH  - Ukraine
MH  - Young Adult
EDAT- 2015/09/04 06:00
MHDA- 2015/12/17 06:00
CRDT- 2015/09/04 06:00
PHST- 2015/09/04 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - 000430762 [pii]
AID - 10.1159/000430762 [doi]
PST - ppublish
SO  - Forsch Komplementmed. 2015;22(3):163-70. doi: 10.1159/000430762. Epub 2015 May 
      12.