PMID- 26335292
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20151010
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 37
IP  - 9
DP  - 2015
TI  - MCP1 2518 A/G polymorphism affects progression of childhood focal segmental 
      glomerulosclerosis.
PG  - 1435-9
LID - 10.3109/0886022X.2015.1074474 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a highly specific chemokine for 
      monocytes and plays roles in pathogenesis of various renal diseases. The aim of 
      this study is to investigate the effect of MCP1 2518 A/G polymorphism on the 
      incidence and clinical course of focal segmental glomerulosclerosis (FSGS) in 
      children. MCP1 2518 A/G genotype was identified by PCR-RFLP in 60 biopsy-proven 
      FSGS patients, 76 steroid sensitive nephrotic syndrome (SSNS) patients, and 96 
      healthy children. MCP-1 levels in urine and serum were measured by ELISA in all 
      patients and the correlations of genotype with MCP-1 levels and clinical outcome 
      were evaluated. The genotype frequencies for MCP1 were similar in all groups. The 
      percentage of patients who develop chronic renal failure was higher in patients 
      with AA allele compared to GA or GG alleles (46% vs. 35% respectively, p < 0.01, 
      Odds ratio: 1.59). Serum MCP-1 levels were similar in all groups, whereas urinary 
      MCP-1 levels of the patients with FSGS (1680 pg/mg creatinine) were significantly 
      higher than that of patients with SSNS (365 pg/mg creatinine, p < 0.05) and 
      healthy controls (348 pg/mg creatinine; p < 0.05). Urinary MCP-1 levels were 
      correlated with the degree of proteinuria in FSGS group (r = 0.529, p = 0.016). 
      Our results suggest that the AA genotype might be a risk factor for the 
      progression of renal disease in FSGS and MCP1 genotyping may help the physicians 
      to predict prognosis in these patients.
FAU - Besbas, Nesrin
AU  - Besbas N
AD  - a Department of Pediatric Nephrology , Hacettepe University Faculty of Medicine , 
      Ankara , Turkey .
FAU - Kalyoncu, Mukaddes
AU  - Kalyoncu M
AD  - b Department of Pediatric Nephrology , Karadeniz Technical University Faculty of 
      Medicine , Trabzon , Turkey .
FAU - Cil, Onur
AU  - Cil O
AD  - a Department of Pediatric Nephrology , Hacettepe University Faculty of Medicine , 
      Ankara , Turkey .
FAU - Ozgul, Riza Koksal
AU  - Ozgul RK
AD  - c Department of Pediatric Metabolism , Hacettepe University Faculty of Medicine , 
      Ankara , Turkey .
FAU - Bakkaloglu, Aysin
AU  - Bakkaloglu A
AD  - a Department of Pediatric Nephrology , Hacettepe University Faculty of Medicine , 
      Ankara , Turkey .
FAU - Ozaltin, Fatih
AU  - Ozaltin F
AD  - a Department of Pediatric Nephrology , Hacettepe University Faculty of Medicine , 
      Ankara , Turkey .
AD  - d Nephrogenetics Laboratory, Department of Pediatric Nephrology , Hacettepe 
      University Faculty of Medicine , Ankara , Turkey , and.
AD  - e Hacettepe University Center for Biobanking and Genomics , Ankara , Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150903
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Biopsy
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*genetics/urine
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Genotype
MH  - Glomerulosclerosis, Focal Segmental/*genetics/*pathology
MH  - Humans
MH  - Infant
MH  - Kidney Failure, Chronic/*genetics
MH  - Male
MH  - Nephrotic Syndrome/*genetics
MH  - Polymorphism, Genetic
MH  - Prognosis
MH  - Proteinuria/urine
OTO - NOTNLM
OT  - Children
OT  - FSGS
OT  - MCP-1
OT  - nephrotic syndrome
OT  - polymorphism
EDAT- 2015/09/04 06:00
MHDA- 2016/08/02 06:00
CRDT- 2015/09/04 06:00
PHST- 2015/09/04 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - 10.3109/0886022X.2015.1074474 [doi]
PST - ppublish
SO  - Ren Fail. 2015;37(9):1435-9. doi: 10.3109/0886022X.2015.1074474. Epub 2015 Sep 3.