PMID- 26336396 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150904 LR - 20201001 IS - 1731-5530 (Print) IS - 1897-4252 (Electronic) IS - 1731-5530 (Linking) VI - 11 IP - 1 DP - 2014 Mar TI - Five-year survival of patients with chronic systolic heart failure of ischemic and non-ischemic etiology: analysis of prognostic factors. PG - 56-62 LID - 10.5114/kitp.2014.41933 [doi] AB - INTRODUCTION: Despite advances in pharmacotherapy, electrotherapy and interventional treatment, chronic heart failure (HF) is still associated with poor long-term outcome. AIM OF THE STUDY: To determine the death rate and risk factors in patients with HF of ischemic and non-ischemic etiology in five-year follow-up. MATERIAL AND METHODS: Consecutive patients with chronic systolic HF hospitalized in the period 2006-2008 were analyzed retrospectively. Study exclusion criteria were: infections (< 3 months before hospitalization), hemodynamically significant valve disease, advanced chronic kidney disease, liver cirrhosis and neoplastic diseases (< 5 years before hospitalization). RESULTS: The analysis encompassed 266 patients divided into two groups: Group A, with HF of ischemic etiology (n = 157), and Group B, with HF of non-ischemic etiology (n = 109). Mortality was significantly higher in Group A than in Group B (49% vs. 28.4%, p = 0.001). The independent risk factors for death in Group A were: New York Heart Association (NYHA) class (HR = 1.81; p < 0.001); concentrations of high-sensitivity C-reactive protein (hs-CRP) (HR = 1.01; p < 0.05), fibrinogen (HR = 1.04; p < 0.001) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) (HR = 1.02; p < 0.001); and right ventricular end-diastolic diameter (RVEDd) (HR = 1.07; p < 0.01). In Group B they were age (HR = 1.07; p < 0.05) and NT-proBNP concentration (HR = 1.03; p < 0.001). CONCLUSIONS: Mortality was significantly lower in Group B than in Group A. The independent risk factors for death in Group B were age and NT-proBNP serum concentration, whilst in Group A they were NYHA class, serum concentrations of hs-CRP, NT-proBNP and fibrinogen, and RVEDd. FAU - Moscinski, Mateusz AU - Moscinski M AD - Cardiology Department, Regional Specialist Hospital No. 4 in Bytom. FAU - Szygula-Jurkiewicz, Bozena AU - Szygula-Jurkiewicz B AD - 3 Chair and Clinical Department of Cardiology, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze. FAU - Zakliczynski, Michal AU - Zakliczynski M AD - Chair and Clinical Department of Cardiac Surgery and Transplantation, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze. FAU - Rozentryt, Piotr AU - Rozentryt P AD - 3 Chair and Clinical Department of Cardiology, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze. FAU - Partyka, Robert AU - Partyka R AD - Department of Anesthesiology, Intensive Care and Emergency Medicine, Medical University of Silesia, Katowice. FAU - Zembala, Marian AU - Zembala M AD - Chair and Clinical Department of Cardiac Surgery and Transplantation, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze. FAU - Polonski, Lech AU - Polonski L AD - 3 Chair and Clinical Department of Cardiology, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze. LA - eng PT - Journal Article DEP - 20140327 PL - Poland TA - Kardiochir Torakochirurgia Pol JT - Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery JID - 101279148 PMC - PMC4283904 OTO - NOTNLM OT - chronic systolic heart failure OT - prognostic factors EDAT- 2014/03/01 00:00 MHDA- 2014/03/01 00:01 PMCR- 2014/03/01 CRDT- 2015/09/04 06:00 PHST- 2013/10/06 00:00 [received] PHST- 2013/11/26 00:00 [revised] PHST- 2014/02/13 00:00 [accepted] PHST- 2015/09/04 06:00 [entrez] PHST- 2014/03/01 00:00 [pubmed] PHST- 2014/03/01 00:01 [medline] PHST- 2014/03/01 00:00 [pmc-release] AID - 22557 [pii] AID - 10.5114/kitp.2014.41933 [doi] PST - ppublish SO - Kardiochir Torakochirurgia Pol. 2014 Mar;11(1):56-62. doi: 10.5114/kitp.2014.41933. Epub 2014 Mar 27.