PMID- 26336563
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150904
LR  - 20201001
IS  - 1880-4276 (Print)
IS  - 1883-2148 (Electronic)
IS  - 1880-4276 (Linking)
VI  - 31
IP  - 4
DP  - 2015 Aug
TI  - The effectiveness of cardiac resynchronization therapy for patients with New York 
      Heart Association class IV non-ambulatory heart failure.
PG  - 221-5
LID - 10.1016/j.joa.2014.12.008 [doi]
AB  - BACKGROUND: We reviewed the effectiveness and safety of cardiac resynchronization 
      therapy (CRT) for patients with New York Heart Association (NYHA) class IV 
      non-ambulatory heart failure (NAHF). METHODS: From 2006 to 2011, 310 patients 
      underwent CRT at Kobe University Hospital and Himeji Cardiovascular Center 
      because of heart failure. Of these, 29 NAHF patients were retrospectively 
      analyzed. The control group comprised 21 age- and ejection fraction-matched 
      patients with NAHF who did not undergo CRT from the ICU database of Kobe 
      University Hospital. The primary endpoint was all-cause death and hospitalization 
      for heart failure. Response was defined as a >15% reduction in left ventricular 
      end-systolic volume (LVESV). RESULTS: CRT was performed successfully without 
      serious complications in all patients. Twenty-three patients (79%) were 
      discharged 19+/-15 days after CRT implantation, while 6 (21%) died during their 
      hospital stay due to progressive heart failure. Compared with the control group, 
      patients in the CRT group showed significant improvements in the primary endpoint 
      (log-rank p=0.04). Six patients (21%) were defined as responders and the 
      Kaplan-Meier curve showed that responders experienced a better outcome than 
      non-responders (log-rank p=0.029). LV dyssynchrony before implantation was 
      significantly related to the occurrence of the primary endpoint (p=0.02). 
      CONCLUSIONS: CRT can be safely used in patients with NAHF and can improve 
      long-term patient outcomes, especially in treatment responders.
FAU - Yamashita, Soichiro
AU  - Yamashita S
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan.
FAU - Fukuzawa, Koji
AU  - Fukuzawa K
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan ; 
      Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, 
      Kobe, Japan.
FAU - Yoshida, Akihiro
AU  - Yoshida A
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan ; 
      Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, 
      Kobe, Japan.
FAU - Itoh, Mitsuaki
AU  - Itoh M
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan.
FAU - Imamura, Kimitake
AU  - Imamura K
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan.
FAU - Fujiwara, Ryudo
AU  - Fujiwara R
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan.
FAU - Suzuki, Atsushi
AU  - Suzuki A
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan.
FAU - Nakanishi, Tomoyuki
AU  - Nakanishi T
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan.
FAU - Matsumoto, Akinori
AU  - Matsumoto A
AD  - Section of Arrhythmia, Division of Cardiovascular Medicine, Kobe University 
      Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chu-ou-ku, Kobe, Japan.
FAU - Kanda, Gaku
AU  - Kanda G
AD  - Department of Cardiology, Himeji Cardiovascular Center, Himeji, Japan.
FAU - Kiuchi, Kunihiko
AU  - Kiuchi K
AD  - Department of Cardiology, Himeji Cardiovascular Center, Himeji, Japan.
FAU - Shimane, Akira
AU  - Shimane A
AD  - Department of Cardiology, Himeji Cardiovascular Center, Himeji, Japan.
FAU - Okajima, Katsunori
AU  - Okajima K
AD  - Department of Cardiology, Himeji Cardiovascular Center, Himeji, Japan.
FAU - Tanaka, Hidekazu
AU  - Tanaka H
AD  - Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, 
      Kobe, Japan.
FAU - Hirata, Ken-Ichi
AU  - Hirata K
AD  - Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, 
      Kobe, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150213
PL  - Japan
TA  - J Arrhythm
JT  - Journal of arrhythmia
JID - 101263026
PMC - PMC4556084
OTO - NOTNLM
OT  - Cardiac resynchronization therapy
OT  - Heart failure
OT  - NYHA IV
OT  - Radial strain dyssynchrony
EDAT- 2015/09/04 06:00
MHDA- 2015/09/04 06:01
PMCR- 2015/02/13
CRDT- 2015/09/04 06:00
PHST- 2014/11/18 00:00 [received]
PHST- 2014/12/12 00:00 [revised]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/09/04 06:00 [entrez]
PHST- 2015/09/04 06:00 [pubmed]
PHST- 2015/09/04 06:01 [medline]
PHST- 2015/02/13 00:00 [pmc-release]
AID - S1880-4276(15)00005-8 [pii]
AID - 10.1016/j.joa.2014.12.008 [doi]
PST - ppublish
SO  - J Arrhythm. 2015 Aug;31(4):221-5. doi: 10.1016/j.joa.2014.12.008. Epub 2015 Feb 
      13.