PMID- 26337454
OWN - NLM
STAT- MEDLINE
DCOM- 20170612
LR  - 20190320
IS  - 1744-5205 (Electronic)
IS  - 0882-0538 (Linking)
VI  - 32
IP  - 3
DP  - 2017
TI  - Assessment of Corneal Parameters with Scheimpflug Imaging in Patients with 
      Ankylosing Spondylitis.
PG  - 276-280
LID - 10.3109/08820538.2015.1068340 [doi]
AB  - PURPOSE: To evaluate corneal parameters of patients with ankylosing spondylitis 
      (AS) by Scheimpflug imaging and also to clarify the associations between disease 
      severity and clinical status of AS and corneal parameters. METHODS: Fifty-seven 
      patients with AS and 57 healthy subjects were included in this cross-sectional 
      study. All participants underwent a detailed ophthalmological evaluation. Corneal 
      parameters were measured by Pentacam. In addition, Schirmer test, tear break-up 
      time (TBUT), corneal fluorescein staining, and Ocular Surface Disease Index 
      (OSDI) scores were evaluated. Duration of disease and scores of Bath Ankylosing 
      Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Quality of 
      Life scale (ASQoL) of the patients were recorded. The laboratory evaluation 
      consisted of human leukocyte antigen (HLA)-B27, erythrocyte sedimentation rate 
      (ESR), and C-reactive protein (CRP). RESULTS: Corneal parameters were 
      significantly different between patients with AS and healthy controls. The mean 
      central corneal thickness (538 +/- 26 microm versus 569 +/- 27 microm, p < 0.001) and the 
      mean corneal volume (59.8 +/- 3.33 mm(3) versus 62.3 +/- 3.40 mm(3), p < 0.001) were 
      reduced significantly in AS patients compared to those in healthy controls. The 
      values of TBUT and Schirmer test scores were significantly lower in AS patients 
      than in controls. Also, corneal fluorescein staining and OSDI scores were higher 
      in AS patients than in controls. Factors related to the corneal parameters were 
      dry eye tests (TBUT, Schirmer test, corneal fluorescein staining), OSDI score, 
      and CRP (p < 0.05 for all). CONCLUSION: The AS patients have thinner corneas 
      compared to control subjects, which may be affected by tear disfunction and 
      inflammatory processes.
FAU - Gunes, Alime
AU  - Gunes A
AD  - a Department of Ophthalmology , Suleyman Demirel University Faculty of Medicine , 
      Isparta , Turkey.
FAU - Erkol Inal, Esra
AU  - Erkol Inal E
AD  - b Department of Physical Medicine and Rehabilitation , Suleyman Demirel 
      University Faculty of Medicine , Isparta , Turkey.
FAU - Tok, Levent
AU  - Tok L
AD  - a Department of Ophthalmology , Suleyman Demirel University Faculty of Medicine , 
      Isparta , Turkey.
FAU - Tok, Ozlem
AU  - Tok O
AD  - a Department of Ophthalmology , Suleyman Demirel University Faculty of Medicine , 
      Isparta , Turkey.
LA  - eng
PT  - Journal Article
DEP - 20150904
PL  - England
TA  - Semin Ophthalmol
JT  - Seminars in ophthalmology
JID - 8610759
SB  - IM
MH  - Adult
MH  - Cornea/metabolism/*pathology
MH  - Corneal Topography/*methods
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Quality of Life
MH  - Severity of Illness Index
MH  - Spondylitis, Ankylosing/*complications/diagnosis
MH  - Surveys and Questionnaires
MH  - Tears/metabolism
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - Pentacam
OT  - corneal thickness
OT  - corneal volume
OT  - dry eye test
EDAT- 2015/09/05 06:00
MHDA- 2019/03/21 06:00
CRDT- 2015/09/05 06:00
PHST- 2015/09/05 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2015/09/05 06:00 [entrez]
AID - 10.3109/08820538.2015.1068340 [doi]
PST - ppublish
SO  - Semin Ophthalmol. 2017;32(3):276-280. doi: 10.3109/08820538.2015.1068340. Epub 
      2015 Sep 4.