PMID- 26337813
OWN - NLM
STAT- MEDLINE
DCOM- 20170102
LR  - 20201209
IS  - 1435-5922 (Electronic)
IS  - 0944-1174 (Linking)
VI  - 51
IP  - 4
DP  - 2016 Apr
TI  - The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis 
      patients with type 2 diabetes mellitus.
PG  - 370-9
LID - 10.1007/s00535-015-1116-6 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is an established independent risk 
      factor for hepatocellular carcinoma (HCC). T2DM is associated with non-alcoholic 
      steatohepatitis (NASH), which is a major cause of non-HBV and non-HCV-related 
      HCC; nevertheless, it has been difficult to identify those patients with T2DM who 
      have a high risk of developing HCC. The aim of this study was to identify genetic 
      determinants that predispose T2DM patients to HCC by genotyping T2DM 
      susceptibility loci and PNPLA3. METHODS: We recruited 389 patients with T2DM who 
      satisfied the following three criteria: negative for HBs-Ag and anti-HCV Ab, 
      alcohol intake <60 g/day, and history of T2DM >10 years. These patients were 
      divided into two groups: T2DM patients with HCC (DM-HCC, n = 59) or those without 
      HCC (DM-non-HCC, n = 330). We genotyped 51 single-nucleotide polymorphisms (SNPs) 
      previously reported as T2DM or NASH susceptibility loci (PNPLA3) compared between 
      the DM-HCC and DM-non-HCC groups with regard to allele frequencies at each SNP. 
      RESULTS: The SNP rs738409 located in PNPLA3 was the greatest risk factor 
      associated with HCC. The frequency of the PNPLA3 G allele was significantly 
      higher among DM-HCC individuals than DM-non-HCC individuals (OR 2.53, p = 1.05 x 
      10(-5)). Among individuals homozygous for the PNPLA3 G allele (n = 115), the 
      frequency of the JAZF1 rs864745 G allele was significantly higher among DM-HCC 
      individuals than DM-non-HCC individuals (OR 3.44, p = 0.0002). CONCLUSIONS: 
      PNPLA3 and JAZF1 were associated with non-HBV and non-HCV-related HCC development 
      among Japanese patients with T2DM.
FAU - Ueyama, Misuzu
AU  - Ueyama M
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
AD  - Department of Gastroenterology, Juntendo University School of Medicine, 
      Bunkyo-Ku, Tokyo, Japan.
FAU - Nishida, Nao
AU  - Nishida N
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Korenaga, Masaaki
AU  - Korenaga M
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan. 
      dmkorenaga@hospk.ncgm.go.jp.
FAU - Korenaga, Keiko
AU  - Korenaga K
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Kumagai, Erina
AU  - Kumagai E
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
AD  - Department of Gastroenterology, Juntendo University School of Medicine, 
      Bunkyo-Ku, Tokyo, Japan.
FAU - Yanai, Hidekatsu
AU  - Yanai H
AD  - Department of Internal Medicine, National Center for Global Health and Medicine 
      Kohnodai Hospital, Ichikawa, Chiba, Japan.
FAU - Adachi, Hiroki
AU  - Adachi H
AD  - Department of Internal Medicine, National Center for Global Health and Medicine 
      Kohnodai Hospital, Ichikawa, Chiba, Japan.
FAU - Katsuyama, Hisayuki
AU  - Katsuyama H
AD  - Department of Internal Medicine, National Center for Global Health and Medicine 
      Kohnodai Hospital, Ichikawa, Chiba, Japan.
FAU - Moriyama, Sumie
AU  - Moriyama S
AD  - Department of Internal Medicine, National Center for Global Health and Medicine 
      Kohnodai Hospital, Ichikawa, Chiba, Japan.
FAU - Hamasaki, Hidetaka
AU  - Hamasaki H
AD  - Department of Internal Medicine, National Center for Global Health and Medicine 
      Kohnodai Hospital, Ichikawa, Chiba, Japan.
FAU - Sako, Akahito
AU  - Sako A
AD  - Department of Internal Medicine, National Center for Global Health and Medicine 
      Kohnodai Hospital, Ichikawa, Chiba, Japan.
FAU - Sugiyama, Masaya
AU  - Sugiyama M
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Aoki, Yoshihiko
AU  - Aoki Y
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Imamura, Masatoshi
AU  - Imamura M
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Murata, Kazumoto
AU  - Murata K
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Masaki, Naohiko
AU  - Masaki N
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Kawaguchi, Takumi
AU  - Kawaguchi T
AD  - Division of Gastroenterology, Department of Medicine, Kurume University School of 
      Medicine, Kurume, Japan.
FAU - Torimura, Takuji
AU  - Torimura T
AD  - Division of Gastroenterology, Department of Medicine, Kurume University School of 
      Medicine, Kurume, Japan.
FAU - Hyogo, Hideyuki
AU  - Hyogo H
AD  - Department of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, 
      Japan.
FAU - Aikata, Hiroshi
AU  - Aikata H
AD  - Department of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, 
      Japan.
FAU - Ito, Kiyoaki
AU  - Ito K
AD  - Division of Gastroenterology, Department of Internal Medicine, Aichi Medical 
      University School of Medicine, Nagakute, Japan.
FAU - Sumida, Yoshio
AU  - Sumida Y
AD  - Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan.
AD  - Department of Gastroenterology and Hepatology, Kyoto Prefectural University of 
      Medicine, Kamigyo-ku, Kyoto, Japan.
FAU - Kanazawa, Akio
AU  - Kanazawa A
AD  - Department of Metabolism and Endocrinology, Juntendo University Graduate School 
      of Medicine, Bunkyo-Ku, Tokyo, Japan.
FAU - Watada, Hirotaka
AU  - Watada H
AD  - Department of Metabolism and Endocrinology, Juntendo University Graduate School 
      of Medicine, Bunkyo-Ku, Tokyo, Japan.
FAU - Okamoto, Koji
AU  - Okamoto K
AD  - Department of Nephrology and Endocrinology, Department of Hemodialysis and 
      Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan.
FAU - Honda, Kenjiro
AU  - Honda K
AD  - Department of Nephrology and Endocrinology, Department of Hemodialysis and 
      Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan.
FAU - Kon, Kazuyoshi
AU  - Kon K
AD  - Department of Gastroenterology, Juntendo University School of Medicine, 
      Bunkyo-Ku, Tokyo, Japan.
FAU - Kanto, Tatsuya
AU  - Kanto T
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Mizokami, Masashi
AU  - Mizokami M
AD  - The Research Center for Hepatitis and Immunology, National Center for Global 
      Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
FAU - Watanabe, Sumio
AU  - Watanabe S
AD  - Department of Gastroenterology, Juntendo University School of Medicine, 
      Bunkyo-Ku, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150903
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (Co-Repressor Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (JAZF1 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - EC 3.1.1.3 (Lipase)
RN  - EC 3.1.1.3 (adiponutrin, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/etiology/*genetics/pathology
MH  - Co-Repressor Proteins
MH  - DNA-Binding Proteins
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Hepatitis/complications
MH  - Humans
MH  - Lipase/*genetics
MH  - Liver Neoplasms/etiology/*genetics/pathology
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Middle Aged
MH  - Neoplasm Proteins/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - JAZF1
OT  - PNPLA3
OT  - Type 2 diabetes mellitus
EDAT- 2015/09/05 06:00
MHDA- 2017/01/04 06:00
CRDT- 2015/09/05 06:00
PHST- 2015/07/10 00:00 [received]
PHST- 2015/08/14 00:00 [accepted]
PHST- 2015/09/05 06:00 [entrez]
PHST- 2015/09/05 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
AID - 10.1007/s00535-015-1116-6 [pii]
AID - 10.1007/s00535-015-1116-6 [doi]
PST - ppublish
SO  - J Gastroenterol. 2016 Apr;51(4):370-9. doi: 10.1007/s00535-015-1116-6. Epub 2015 
      Sep 3.