PMID- 26338891
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 145
IP  - 10
DP  - 2015 Oct
TI  - Consumption of Honey, Sucrose, and High-Fructose Corn Syrup Produces Similar 
      Metabolic Effects in Glucose-Tolerant and -Intolerant Individuals.
PG  - 2265-72
LID - 10.3945/jn.115.218016 [doi]
AB  - BACKGROUND: Public health recommendations call for a reduction in added sugars; 
      however, controversy exists over whether all nutritive sweeteners produce similar 
      metabolic effects. OBJECTIVE: The objective was to compare the effects of the 
      chronic consumption of 3 nutritive sweeteners [honey, sucrose, and high-fructose 
      corn syrup containing 55% fructose (HFCS55)] on circulating glucose, insulin, 
      lipids, and inflammatory markers; body weight; and blood pressure in individuals 
      with normal glucose tolerance (GT) and those with impaired glucose tolerance 
      (IGT). METHODS: In a crossover design, participants consumed daily, in random 
      order, 50 g carbohydrate from assigned sweeteners for 2 wk with a 2- to 4-wk 
      washout period between treatments. Participants included 28 GT and 27 IGT 
      volunteers with a mean age of 38.9 +/- 3.6 y and 52.1 +/- 2.7 y, respectively, and a 
      body mass index (in kg/m(2)) of 26 +/- 0.8 and 31.5 +/- 1.0, respectively. Body 
      weight, blood pressure (BP), serum inflammatory markers, lipids, fasting glucose 
      and insulin, and oral-glucose-tolerance tests (OGTTs) were completed pre- and 
      post-treatment. The OGTT incremental areas under the curve (iAUCs) for glucose 
      and insulin were determined and homeostasis model assessment of insulin 
      resistance (HOMA-IR) scores were calculated. RESULTS: Body weight and serum 
      glucose, insulin, inflammatory markers, and total and LDL-cholesterol 
      concentrations were significantly higher in the IGT group than in the GT group at 
      baseline. Glucose, insulin, HOMA-IR, and the OGTT iAUC for glucose or insulin did 
      not differ by treatment, but all responses were significantly higher in the IGT 
      group compared with the GT group. Body weight was unchanged by treatment. 
      Systolic BP was unchanged, whereas diastolic BP was significantly lower in 
      response to sugar intake across all treatments. An increase in high-sensitivity 
      C-reactive protein (hsCRP) was observed in the IGT group in response to all 
      sugars. No treatment effect was observed for interleukin 6. HDL cholesterol did 
      not differ as a result of status or treatment. Triglyceride (TG) concentrations 
      increased significantly from pre- to post-treatment in response to all sugars 
      tested. CONCLUSIONS: Daily intake of 50 g carbohydrate from honey, sucrose, or 
      HFCS55 for 14 d resulted in similar effects on measures of glycemia, lipid 
      metabolism, and inflammation. All 3 increased TG concentrations in both GT and 
      IGT individuals and elevated glycemic and inflammatory responses in the latter. 
      This trial was registered at clinicaltrials.gov as NCT01371266.
CI  - (c) 2015 American Society for Nutrition.
FAU - Raatz, Susan K
AU  - Raatz SK
AUID- ORCID: 0000-0001-8965-8850
AD  - USDA Agricultural Research Service, Grand Forks Human Nutrition Research Center, 
      Grand Forks, ND; and Department of Food Science and Nutrition, University of 
      Minnesota, St. Paul, MN susan.raatz@ars.usda.gov.
FAU - Johnson, LuAnn K
AU  - Johnson LK
AUID- ORCID: 0000-0001-9225-4320
AD  - USDA Agricultural Research Service, Grand Forks Human Nutrition Research Center, 
      Grand Forks, ND; and.
FAU - Picklo, Matthew J
AU  - Picklo MJ
AD  - USDA Agricultural Research Service, Grand Forks Human Nutrition Research Center, 
      Grand Forks, ND; and.
LA  - eng
SI  - ClinicalTrials.gov/NCT01371266
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150902
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Biomarkers)
RN  - 0 (Dietary Sucrose)
RN  - 0 (High Fructose Corn Syrup)
RN  - 0 (Nutritive Sweeteners)
RN  - 0 (Triglycerides)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - C-Reactive Protein/*agonists/analysis
MH  - Cross-Over Studies
MH  - Dietary Sucrose/*adverse effects
MH  - Female
MH  - Glucose Intolerance/complications/epidemiology/immunology/*metabolism
MH  - High Fructose Corn Syrup/*adverse effects
MH  - Honey/*adverse effects
MH  - Humans
MH  - Hypertriglyceridemia/etiology/prevention & control
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - North Dakota/epidemiology
MH  - Nutritive Sweeteners/*adverse effects/therapeutic use
MH  - Obesity/complications
MH  - Overweight/complications
MH  - Patient Dropouts
MH  - Risk Factors
MH  - Triglycerides/agonists/blood
OTO - NOTNLM
OT  - glycemia
OT  - high-fructose corn syrup
OT  - honey
OT  - sucrose
OT  - triglycerides
EDAT- 2015/09/05 06:00
MHDA- 2016/01/14 06:00
CRDT- 2015/09/05 06:00
PHST- 2015/05/28 00:00 [received]
PHST- 2015/08/10 00:00 [accepted]
PHST- 2015/09/05 06:00 [entrez]
PHST- 2015/09/05 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
AID - S0022-3166(22)08888-5 [pii]
AID - 10.3945/jn.115.218016 [doi]
PST - ppublish
SO  - J Nutr. 2015 Oct;145(10):2265-72. doi: 10.3945/jn.115.218016. Epub 2015 Sep 2.