PMID- 26339252
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150905
LR  - 20201001
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2015
DP  - 2015
TI  - Study of Bone Marrow Mesenchymal and Tendon-Derived Stem Cells Transplantation on 
      the Regenerating Effect of Achilles Tendon Ruptures in Rats.
PG  - 984146
LID - 10.1155/2015/984146 [doi]
LID - 984146
AB  - Comparative therapeutic significance of tendon-derived stem cells (TDSCs) and 
      bone marrow mesenchymal stem cells (BMSCs) transplantation to treat ruptured 
      Achilles tendon was studied. Three groups of SD rats comprising 24 rats each, 
      designated as TDSCs and BMSCs, and nontreated were studied for regenerative 
      effects through morpho-histological evaluations and ultimate failure load. For 
      possible mechanism in tendon repair/regeneration through TDSCs and BMSCs, we 
      measured Collagen-I (Col-I), Col-III gene expression level by RT-PCR, and 
      Tenascin-C expression via immunofluorescent assay. TDSCs showed higher agility in 
      tendon healing with better appearance density and well-organized longitudinal 
      fibrous structure, though BMSCs also showed positive effects. Initially the 
      ultimate failure load was considerably higher in TDSCs than other two study 
      groups during the weeks 1 and 2, but at week 4 it attained an average or healthy 
      tendon strength of 30.2 N. Similar higher tendency in Col-I/III gene expression 
      level during weeks 1, 2, and 4 was observed in TDSCs treated group with an 
      upregulation of 1.5-fold and 1.1-fold than the other two study groups. 
      Immunofluorescent assay revealed higher expression of Tenascin-C in TDSCs at week 
      1, while both TDSCs and BMSCs treated groups showed detectable CM-Dil-labelled 
      cells at week 4. Compared with BMSCs, TDSCs showed higher regenerative potential 
      while treating ruptured Achilles tendons in rats.
FAU - Al-Ani, Mohanad Kh
AU  - Al-Ani MKh
AD  - Key Laboratory of Biorheological Science and Technology, Ministry of Education, 
      Bioengineering College, Chongqing University, Chongqing 400030, China ; 
      Veterinary College, Tikrit University, Ministry of Higher Education, Tikrit, 
      Iraq.
FAU - Xu, Kang
AU  - Xu K
AD  - Key Laboratory of Biorheological Science and Technology, Ministry of Education, 
      Bioengineering College, Chongqing University, Chongqing 400030, China.
FAU - Sun, Yanjun
AU  - Sun Y
AD  - Key Laboratory of Biorheological Science and Technology, Ministry of Education, 
      Bioengineering College, Chongqing University, Chongqing 400030, China.
FAU - Pan, Lianhong
AU  - Pan L
AD  - Key Laboratory of Biorheological Science and Technology, Ministry of Education, 
      Bioengineering College, Chongqing University, Chongqing 400030, China.
FAU - Xu, ZhiLing
AU  - Xu Z
AD  - Key Laboratory of Biorheological Science and Technology, Ministry of Education, 
      Bioengineering College, Chongqing University, Chongqing 400030, China.
FAU - Yang, Li
AU  - Yang L
AD  - Key Laboratory of Biorheological Science and Technology, Ministry of Education, 
      Bioengineering College, Chongqing University, Chongqing 400030, China.
LA  - eng
PT  - Journal Article
DEP - 20150803
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC4539207
EDAT- 2015/09/05 06:00
MHDA- 2015/09/05 06:01
PMCR- 2015/08/03
CRDT- 2015/09/05 06:00
PHST- 2014/08/13 00:00 [received]
PHST- 2014/12/23 00:00 [accepted]
PHST- 2015/09/05 06:00 [entrez]
PHST- 2015/09/05 06:00 [pubmed]
PHST- 2015/09/05 06:01 [medline]
PHST- 2015/08/03 00:00 [pmc-release]
AID - 10.1155/2015/984146 [doi]
PST - ppublish
SO  - Stem Cells Int. 2015;2015:984146. doi: 10.1155/2015/984146. Epub 2015 Aug 3.