PMID- 26339256
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150904
LR  - 20240322
IS  - 1735-5362 (Print)
IS  - 1735-9414 (Electronic)
IS  - 1735-5362 (Linking)
VI  - 9
IP  - 6
DP  - 2014 Nov-Dec
TI  - The effects of technical and compositional variables on the size and release 
      profile of bovine serum albumin from PLGA based particulate systems.
PG  - 407-20
AB  - Double emulsion solvent evaporation technique is one of the most attractive 
      methods used to prepare micro and nanoparticles in pharmaceutical areas of 
      interest, but because of the effects of many formulation factors on the size and 
      release behavior of the fabricated particles, optimization of the formulation 
      factors is needed. In this study various parameters including technical and 
      compositional variables were considered to achieve an optimized formulation with 
      desire characteristics especially size and the release profiles, using high shear 
      homogenizer. In this regard, bovine serum albumin (BSA) was used as the model 
      protein and double emulsion was formed with the addition of Tween 80 and Span 80 
      as surfactants for inner aqueous phase and oil phase, respectively. Hydroxypropyl 
      beta cyclodextrin was used as protein stabilizer. After optimization steps, 
      composite nanoparticles (core-shell) were made based on optimized formulation by 
      hyaluronic acid as shell and poly lactic-co-glycolic acid (PLGA) as core 
      material. Formulation of the BSA loaded PLGA nanoparticles using core shell 
      strategy improved the release pattern of the BSA and diminished burst release. 
      The final composite nanoparticles had the particle size of about 160 nm and 70 % 
      of the loaded BSA was released during 14 days and the release data was better 
      fitted to zero order release kinetics.
FAU - Taghipour, B
AU  - Taghipour B
AD  - Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University 
      of Medical Sciences, Shiraz, I.R. Iran.
FAU - Yakhchali, M
AU  - Yakhchali M
AD  - Deptartment of Pharmaceutics, School of Pharmacy, Tehran University of Medical 
      Sciences, Tehran, I.R. Iran.
FAU - Haririan, I
AU  - Haririan I
AD  - Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical 
      Sciences and Medical Biomaterials Research Centre (MBRC), Tehran, I.R. Iran.
FAU - Tamaddon, A M
AU  - Tamaddon AM
AD  - Center for Nanotechnology in Drug Delivery, Faculty of Pharmacy, Shiraz 
      University of Medical Sciences, Shiraz, I.R. Iran.
FAU - Samani, S Mohammadi
AU  - Samani SM
AD  - Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University 
      of Medical Sciences, Shiraz, I.R. Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Res Pharm Sci
JT  - Research in pharmaceutical sciences
JID - 101516968
PMC - PMC4326979
OTO - NOTNLM
OT  - Biodegradable
OT  - Drug delivery
OT  - Nanocomposite
OT  - PLGA
OT  - Protein
EDAT- 2015/09/05 06:00
MHDA- 2015/09/05 06:01
PMCR- 2014/11/01
CRDT- 2015/09/05 06:00
PHST- 2015/09/05 06:00 [entrez]
PHST- 2015/09/05 06:00 [pubmed]
PHST- 2015/09/05 06:01 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - RPS-9-407 [pii]
PST - ppublish
SO  - Res Pharm Sci. 2014 Nov-Dec;9(6):407-20.