PMID- 26339337
OWN - NLM
STAT- MEDLINE
DCOM- 20161214
LR  - 20181202
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 7
DP  - 2015
TI  - Protective effect of chronic caffeine intake on gene expression of brain derived 
      neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic 
      protein and Ki-67 in Alzheimer's disease.
PG  - 7710-28
AB  - Alzheimer's disease (AD) is a neurodegenerative disorder with progressive 
      degeneration of the hippocampal and cortical neurons. This study was designed to 
      demonstrate the protective effect of caffeine on gene expression of brain derived 
      neurotrophic factor (BDNF) and its receptor neural receptor protein-tyrosine 
      kinase-beta (TrkB) as well as glial fibrillary acidic protein (GFAP) and Ki-67 
      immunoreactivity in Aluminum chloride (AlCl3) induced animal model of AD. Fifty 
      adult rats included in this study were classified into 5 group (10 rats each); 
      negative and positive control groups (I&II), AD model group (III), group treated 
      with caffeine from the start of AD induction (IV) and group treated with caffeine 
      two weeks before AD induction (V). Hippocampal tissue BDNF and its receptor 
      (TrkB) gene expression by real time RT-PCR in addition to immunohistochemical 
      study of GFAP and Ki67 immunoreactivity were performed for all rats in the study. 
      The results of this study revealed that caffeine has protective effect through 
      improving the histological and immunohistochemical findings induced by AlCl3 as 
      well as BDNF and its receptor gene expression. It could be concluded from the 
      current study, that chronic caffeine consumption in a dose of 1.5 mg/kg body 
      weight daily has a potentially good protective effect against AD.
FAU - Ghoneim, Fatma M
AU  - Ghoneim FM
AD  - Department of Histology and Cell Biology, Mansoura University Egypt.
FAU - Khalaf, Hanaa A
AU  - Khalaf HA
AD  - Department of Histology and Cell Biology, Mansoura University Egypt.
FAU - Elsamanoudy, Ayman Z
AU  - Elsamanoudy AZ
AD  - Department of Medical Biochemistry and Molecular Biology, Mansoura University 
      Egypt.
FAU - Abo El-Khair, Salwa M
AU  - Abo El-Khair SM
AD  - Department of Medical Biochemistry and Molecular Biology, Mansoura University 
      Egypt.
FAU - Helaly, Ahmed M N
AU  - Helaly AM
AD  - Department of Forensic Medicine and Toxicology, Mansoura University Egypt.
FAU - Mahmoud, El-Hassanin M
AU  - Mahmoud el-HM
AD  - Department of Psychiatry, Faculty of Medicine, Mansoura University Egypt.
FAU - Elshafey, Saad H
AU  - Elshafey SH
AD  - Department of Histology and Cell Biology, Mansoura University Egypt.
LA  - eng
PT  - Journal Article
DEP - 20150701
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Aluminum Compounds)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Chlorides)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Ki-67 Antigen)
RN  - 3CYT62D3GA (Aluminum Chloride)
RN  - 3G6A5W338E (Caffeine)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Aluminum Chloride
MH  - Aluminum Compounds/adverse effects
MH  - Alzheimer Disease/chemically induced/*drug therapy/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Caffeine/*pharmacology
MH  - Chlorides/adverse effects
MH  - Disease Models, Animal
MH  - Gene Expression Regulation/*drug effects
MH  - Glial Fibrillary Acidic Protein/genetics/metabolism
MH  - Hippocampus/drug effects/pathology
MH  - Humans
MH  - Ki-67 Antigen/genetics/metabolism
MH  - Male
MH  - Neurons/drug effects/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/genetics/metabolism
MH  - Signal Transduction/*drug effects
PMC - PMC4555665
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BNDF signaling
OT  - Caffeine
OT  - Ki-67
OT  - glial fibrillary acidic protein
EDAT- 2015/09/05 06:00
MHDA- 2016/12/15 06:00
PMCR- 2015/07/01
CRDT- 2015/09/05 06:00
PHST- 2015/05/11 00:00 [received]
PHST- 2015/06/26 00:00 [accepted]
PHST- 2015/09/05 06:00 [entrez]
PHST- 2015/09/05 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Jul 1;8(7):7710-28. eCollection 2015.