PMID- 26339755
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20180813
IS  - 2047-2927 (Electronic)
IS  - 2047-2919 (Linking)
VI  - 3
IP  - 6
DP  - 2015 Nov
TI  - Hypovitaminosis D is associated with lower urinary tract symptoms and benign 
      prostate hyperplasia in type 2 diabetes.
PG  - 1062-7
LID - 10.1111/andr.12092 [doi]
AB  - Lower urinary tract symptoms (LUTS) may develop more commonly in men with type 2 
      diabetes mellitus (T2DM). LUTS are often associated with benign prostate 
      hyperplasia (BPH), in general population. An association between LUTS and 
      hypovitaminosis D, and between hypovitaminosis D and type 2 diabetes (T2DM), has 
      also been suggested. Thus, we aim to evaluate possible relationships between 
      hypovitaminosis D, LUTS, and BPH in T2DM men. In this prospective observational 
      study, 67 T2DM males (57.9 +/- 9.28 years) underwent medical history collection, 
      International Prostate Symptom Score (IPSS) questionnaire, that allows the 
      identification and grading of LUTS, physical examination, biochemical/hormonal 
      blood tests (fasting plasma glucose, glycated haemoglobin, total cholesterol, 
      high-density lipoprotein cholesterol, triglycerides, creatinine, LH, total 
      testosterone, estradiol (E2 ), 25-OH-vitamin D, PTH, calcium, phosphate, and PSA) 
      and ultrasound transrectal prostate examination. Subdividing patients into three 
      groups, on the base of 25-OH-vitamin D concentration (sufficiency >/=50; 
      insufficiency >25 < 50; and deficiency </=25 nm), a significant progressive 
      increase of prostate volume (p = 0.037), IPSS score (p = 0.019), diastolic blood 
      pressure (p = 0.018), and a significant decrease in HDL cholesterol (p = 0.038) 
      were observed. 25-OH-Vitamin D levels were inversely correlated with both IPSS (R 
      = -0.333; p = 0.006) and prostate volume (R = -0.311; p = 0.011). At multivariate 
      analysis, hypovitaminosis D remained an independent predictor of both IPSS and 
      prostate volume. In conclusion, we showed, for the first time, an association 
      between 25-OH-vitamin D deficiency, LUTS, and BPH in T2DM men.
CI  - (c) 2015 American Society of Andrology and European Academy of Andrology.
FAU - Caretta, N
AU  - Caretta N
AD  - Department of Medicine, Section of Endocrinology and Centre for Human 
      Reproduction Pathology, University of Padova, Padova, Italy.
FAU - Vigili de Kreutzenberg, S
AU  - Vigili de Kreutzenberg S
AD  - Department of Medicine, Section of Diabetes and Metabolic Diseases, University of 
      Padova, Padova, Italy.
FAU - Valente, U
AU  - Valente U
AD  - Department of Medicine, Section of Endocrinology and Centre for Human 
      Reproduction Pathology, University of Padova, Padova, Italy.
FAU - Guarneri, G
AU  - Guarneri G
AD  - Department of Medicine, Section of Diabetes and Metabolic Diseases, University of 
      Padova, Padova, Italy.
FAU - Pizzol, D
AU  - Pizzol D
AD  - Department of Medicine, Section of Endocrinology and Centre for Human 
      Reproduction Pathology, University of Padova, Padova, Italy.
FAU - Ferlin, A
AU  - Ferlin A
AD  - Department of Medicine, Section of Endocrinology and Centre for Human 
      Reproduction Pathology, University of Padova, Padova, Italy.
FAU - Avogaro, A
AU  - Avogaro A
AD  - Department of Medicine, Section of Diabetes and Metabolic Diseases, University of 
      Padova, Padova, Italy.
FAU - Foresta, C
AU  - Foresta C
AD  - Department of Medicine, Section of Endocrinology and Centre for Human 
      Reproduction Pathology, University of Padova, Padova, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150904
PL  - England
TA  - Andrology
JT  - Andrology
JID - 101585129
RN  - 0 (Biomarkers)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
CIN - J Urol. 2017 Aug;198(2):224-225. PMID: 29370592
MH  - Aged
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/blood/*complications/diagnosis
MH  - Disease Progression
MH  - Humans
MH  - Linear Models
MH  - Lower Urinary Tract Symptoms/blood/*complications/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Prostatic Hyperplasia/blood/*complications/diagnosis
MH  - Risk Factors
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/blood/*complications/diagnosis
OTO - NOTNLM
OT  - benign prostate hyperplasia
OT  - hypovitaminosis D
OT  - lower urinary tract symptoms
OT  - type 2 diabetes
EDAT- 2015/09/05 06:00
MHDA- 2016/11/01 06:00
CRDT- 2015/09/05 06:00
PHST- 2015/01/21 00:00 [received]
PHST- 2015/06/24 00:00 [revised]
PHST- 2015/07/16 00:00 [accepted]
PHST- 2015/09/05 06:00 [entrez]
PHST- 2015/09/05 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - 10.1111/andr.12092 [doi]
PST - ppublish
SO  - Andrology. 2015 Nov;3(6):1062-7. doi: 10.1111/andr.12092. Epub 2015 Sep 4.