PMID- 26341315
OWN - NLM
STAT- MEDLINE
DCOM- 20160314
LR  - 20151123
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 161
IP  - 2
DP  - 2015 Dec
TI  - Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in 
      blood.
PG  - 270-7
LID - S1521-6616(15)30030-9 [pii]
LID - 10.1016/j.clim.2015.08.014 [doi]
AB  - The breakdown of immune tolerance against islet antigens causes type 1 diabetes 
      (T1D). The antigens associated with adult-onset T1D (AT1D) remain largely 
      undefined. It is possible that AT1D patients display a unique type of CD4(+) T 
      cells specific for a certain islet antigen. Here we analyzed the cytokine 
      production profiles of CD4(+) helper T (Th) cells that are specific for three 
      islet antigens; GAD65, preproinsulin, and IGRP in patients with AT1D, 
      juvenile-onset T1D (JT1D), and age-, gender- and human leukocyte antigen 
      (HLA)-matched control adults. While IGRP-specific Th cells in AT1D patients were 
      dominantly Th1 cells, IGRP-specific Th cells in control adults and JT1D patients 
      were dominantly Th2 and T regulatory type 1 (Tr1) cells. Notably, the frequency 
      of IGRP-specific Tr1 cells was significantly lower in AT1D patients than in 
      control adults and JT1D patients. In conclusion, our study suggests that 
      IGRP-specific Th cells play a unique pathogenic role in AT1D.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Chujo, Daisuke
AU  - Chujo D
AD  - Baylor Institute for Immunology Research, Dallas, TX, USA; National Center for 
      Global Health and Medicine, Tokyo, Japan.
FAU - Nguyen, Thien-Son
AU  - Nguyen TS
AD  - Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
FAU - Foucat, Emile
AU  - Foucat E
AD  - Baylor Institute for Immunology Research, Dallas, TX, USA.
FAU - Blankenship, Derek
AU  - Blankenship D
AD  - Baylor Institute for Immunology Research, Dallas, TX, USA.
FAU - Banchereau, Jacques
AU  - Banchereau J
AD  - Baylor Institute for Immunology Research, Dallas, TX, USA.
FAU - Nepom, Gerald T
AU  - Nepom GT
AD  - Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
FAU - Chaussabel, Damien
AU  - Chaussabel D
AD  - Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
FAU - Ueno, Hideki
AU  - Ueno H
AD  - Baylor Institute for Immunology Research, Dallas, TX, USA. Electronic address: 
      HidekiU@baylorhealth.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150902
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 0 (Protein Precursors)
RN  - 61116-24-3 (preproinsulin)
RN  - EC 3.1.3.9 (Glucose-6-Phosphatase)
RN  - EC 3.1.3.9. (G6PC2 protein, human)
RN  - EC 4.1.1.15 (GAD55, human)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Amino Acid Sequence
MH  - CD4-Positive T-Lymphocytes/immunology/metabolism
MH  - Cells, Cultured
MH  - Cytokines/immunology/metabolism
MH  - Diabetes Mellitus, Type 1/blood/*immunology
MH  - Female
MH  - Glucose-6-Phosphatase/*immunology/metabolism
MH  - Glutamate Decarboxylase/immunology/metabolism
MH  - Humans
MH  - Insulin/immunology/metabolism
MH  - Islets of Langerhans/immunology
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Protein Precursors/immunology/metabolism
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - T-Lymphocytes, Helper-Inducer/*immunology/metabolism
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism
MH  - Th1 Cells/immunology/metabolism
OTO - NOTNLM
OT  - CD4 T cells
OT  - Islet antigens
OT  - Islet-specific glucose 6 phosphatase catalytic subunit-related protein
OT  - T regulatory type 1 (Tr1) cells
OT  - Type 1 diabetes
EDAT- 2015/09/06 06:00
MHDA- 2016/03/15 06:00
CRDT- 2015/09/06 06:00
PHST- 2015/06/04 00:00 [received]
PHST- 2015/08/25 00:00 [revised]
PHST- 2015/08/26 00:00 [accepted]
PHST- 2015/09/06 06:00 [entrez]
PHST- 2015/09/06 06:00 [pubmed]
PHST- 2016/03/15 06:00 [medline]
AID - S1521-6616(15)30030-9 [pii]
AID - 10.1016/j.clim.2015.08.014 [doi]
PST - ppublish
SO  - Clin Immunol. 2015 Dec;161(2):270-7. doi: 10.1016/j.clim.2015.08.014. Epub 2015 
      Sep 2.