PMID- 26341371
OWN - NLM
STAT- MEDLINE
DCOM- 20160725
LR  - 20181113
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Linking)
VI  - 125
IP  - 2
DP  - 2015 Nov
TI  - Prognostic significance of relative 1p/19q codeletion in oligodendroglial tumors.
PG  - 249-51
LID - 10.1007/s11060-015-1906-y [doi]
AB  - 1p/19q codeletion is a favorable prognostic marker for oligodendroglial tumors 
      (OT). Compare outcome in OT with simple deletions of 1p or 19q to those with 
      relative deletions defined as the presence of both increased copy number 
      (polysomy) and 1p/19q codeletion. 525 cases were examined by fluorescence in situ 
      hybridization (FISH) using dual color probes to determine the deletion status of 
      chromosome arms 1p and 19q. Categories included simple deletions defined as a 
      proportion of either 1p32 or 19q13 FISH signals compared to 1q42 or 19p13 signals 
      less than 0.80 and relative deletions (1p or 19q) defined as the combination of a 
      <0.80 proportion with >30 % of nuclei showing increased chromosome number (based 
      on enumeration of 1q25 or 19p13). 464 (80 %) were WHO Grade II or III OT of which 
      209 (48 %) had both 1p and 19q deleted (codeletion). 72 (16 %) had relative 
      deletions for either one or both 1p and 19q of which 28 (6 %) had relative 
      deletions of 1p and 19q (relative codeletion). Overall survival in WHO Grade II 
      OT was 13 + years when 1p/19q codeleted (n = 156); 5 + years in uni- or 
      nondeleted (n = 86); 6 + years in relative deletion for either 1p or 19q (n = 
      41); and 6 + years in relative 1p/19q codeletion (n = 15). Similarly in WHO Grade 
      III OT (n = 168) overall survival was 11 + years in 1p/19q codeleted (n = 54) OT; 
      2.5 years in uni- or nondeleted (n = 70); 3 years in relative deletion for one or 
      both 1p or 19q (n = 31); and 4 + years in relative 1p/19q codeletion (n = 13). 
      Survival for OT regardless of grade with relative codeletion of 1p/19q was 
      approximately one half that of 1p/19q codeleted tumors. The presence of relative 
      1p/19q codeletion is of prognostic significance.
FAU - Chamberlain, Marc C
AU  - Chamberlain MC
AD  - Department of Neurology, University of Washington, Seattle, WA, USA. 
      chambemc@u.washington.edu.
AD  - University of Washington/Fred Hutchison Cancer Research Center, Seattle Cancer 
      Care Alliance, 825 Eastlake Ave E, POB 19023, MS G4940, Seattle, WA, 98109, USA. 
      chambemc@u.washington.edu.
FAU - Born, Donald
AU  - Born D
AD  - Department of Pathology-Neuropathology, Stanford University, Palo Alto, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20150904
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
SB  - IM
MH  - *Brain Neoplasms/classification/diagnosis/genetics
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 19
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - *Oligodendroglioma/classification/diagnosis/genetics
MH  - Prognosis
OTO - NOTNLM
OT  - Oligodendroglioma
OT  - Polysomy
OT  - Relative1p/19q codeletion
EDAT- 2015/09/06 06:00
MHDA- 2016/07/28 06:00
CRDT- 2015/09/06 06:00
PHST- 2015/03/17 00:00 [received]
PHST- 2015/08/29 00:00 [accepted]
PHST- 2015/09/06 06:00 [entrez]
PHST- 2015/09/06 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
AID - 10.1007/s11060-015-1906-y [pii]
AID - 10.1007/s11060-015-1906-y [doi]
PST - ppublish
SO  - J Neurooncol. 2015 Nov;125(2):249-51. doi: 10.1007/s11060-015-1906-y. Epub 2015 
      Sep 4.