PMID- 26341949
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 234
IP  - 1
DP  - 2015 Oct 30
TI  - Serum brain-derived neurotrophic factor and cortical thickness are differently 
      related in patients with schizophrenia and controls.
PG  - 84-9
LID - S0925-4927(15)30066-4 [pii]
LID - 10.1016/j.pscychresns.2015.08.009 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been implicated in neuronal 
      plasticity, a key process related to the pathophysiology of schizophrenia. 
      However, the relationship of peripheral levels of BDNF to cortical thickness and 
      subcortical structures has not been extensively investigated. This study aims to 
      investigate the relationship of peripheral serum BDNF levels to cortical 
      thickness and volumes of the hippocampus and amygdala. Twenty-nine patients with 
      schizophrenia and 32 healthy controls were included in this study. Structural 
      magnetic resonance imaging (MRI) scans obtained in a 1.5 T scanner were performed 
      in all subjects. Images were processed using Freesurfer software. Blood samples 
      were collected on the same day of the MRI scan for BDNF peripheral levels. 
      Vertex-wise analysis revealed significantly thinner cortex in patients compared 
      with controls. BDNF levels and cortical thickness showed different patterns of 
      correlation for patients and healthy controls in one cluster in the right 
      hemisphere distributed across the supramarginal, postcentral, and inferior 
      frontal cortices.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Zugman, Andre
AU  - Zugman A
AD  - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade 
      Federal de Sao Paulo, Rua Pedro de Toledo, 669-3 degrees  andar fundos, Vila Clementino, 
      Sao Paulo, SP, Brazil; Department of Psychosis Study, Institute of Psychiatry, 
      King's College London, 16 De Crespigny Park, SE5 8AF London, UK. Electronic 
      address: andre.zugman@unifesp.br.
FAU - Pedrini, Mariana
AU  - Pedrini M
AD  - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade 
      Federal de Sao Paulo, Rua Pedro de Toledo, 669-3 degrees  andar fundos, Vila Clementino, 
      Sao Paulo, SP, Brazil.
FAU - Gadelha, Ary
AU  - Gadelha A
AD  - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade 
      Federal de Sao Paulo, Rua Pedro de Toledo, 669-3 degrees  andar fundos, Vila Clementino, 
      Sao Paulo, SP, Brazil; Schizophrenia Program, Department of Psychiatry, 
      Universidade Federal de Sao Paulo, Rua Machado Bitencourt, 222, Vila Clementino, 
      Sao Paulo, Brazil.
FAU - Kempton, Matthew J
AU  - Kempton MJ
AD  - Department of Psychosis Study, Institute of Psychiatry, King's College London, 16 
      De Crespigny Park, SE5 8AF London, UK.
FAU - Noto, Cristiano S
AU  - Noto CS
AD  - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade 
      Federal de Sao Paulo, Rua Pedro de Toledo, 669-3 degrees  andar fundos, Vila Clementino, 
      Sao Paulo, SP, Brazil; Schizophrenia Program, Department of Psychiatry, 
      Universidade Federal de Sao Paulo, Rua Machado Bitencourt, 222, Vila Clementino, 
      Sao Paulo, Brazil.
FAU - Mansur, Rodrigo B
AU  - Mansur RB
AD  - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade 
      Federal de Sao Paulo, Rua Pedro de Toledo, 669-3 degrees  andar fundos, Vila Clementino, 
      Sao Paulo, SP, Brazil.
FAU - Santoro, Marcos L
AU  - Santoro ML
AD  - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade 
      Federal de Sao Paulo, Rua Pedro de Toledo, 669-3 degrees  andar fundos, Vila Clementino, 
      Sao Paulo, SP, Brazil.
FAU - Gama, Clarissa S
AU  - Gama CS
AD  - Universidade Federal do Rio Grande do Sul, Avenida Paulo Gama, 110, Porto Alegre, 
      Brazil.
FAU - Bressan, Rodrigo A
AU  - Bressan RA
AD  - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade 
      Federal de Sao Paulo, Rua Pedro de Toledo, 669-3 degrees  andar fundos, Vila Clementino, 
      Sao Paulo, SP, Brazil; Schizophrenia Program, Department of Psychiatry, 
      Universidade Federal de Sao Paulo, Rua Machado Bitencourt, 222, Vila Clementino, 
      Sao Paulo, Brazil.
FAU - McGuire, Philip
AU  - McGuire P
AD  - Department of Psychosis Study, Institute of Psychiatry, King's College London, 16 
      De Crespigny Park, SE5 8AF London, UK.
FAU - Jackowski, Andrea P
AU  - Jackowski AP
AD  - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade 
      Federal de Sao Paulo, Rua Pedro de Toledo, 669-3 degrees  andar fundos, Vila Clementino, 
      Sao Paulo, SP, Brazil.
FAU - Brietzke, Elisa
AU  - Brietzke E
AD  - Schizophrenia Program, Department of Psychiatry, Universidade Federal de Sao 
      Paulo, Rua Machado Bitencourt, 222, Vila Clementino, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150828
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Amygdala/*pathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cerebral Cortex/*pathology/physiopathology
MH  - Female
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Organ Size
MH  - Schizophrenia/*blood/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - Cortical thickness
OT  - Schizophrenia
EDAT- 2015/09/06 06:00
MHDA- 2016/06/28 06:00
CRDT- 2015/09/06 06:00
PHST- 2014/11/08 00:00 [received]
PHST- 2015/06/13 00:00 [revised]
PHST- 2015/08/25 00:00 [accepted]
PHST- 2015/09/06 06:00 [entrez]
PHST- 2015/09/06 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
AID - S0925-4927(15)30066-4 [pii]
AID - 10.1016/j.pscychresns.2015.08.009 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Oct 30;234(1):84-9. doi: 10.1016/j.pscychresns.2015.08.009. 
      Epub 2015 Aug 28.