PMID- 26342279
OWN - NLM
STAT- MEDLINE
DCOM- 20160824
LR  - 20181113
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 57
IP  - 4
DP  - 2015 Dec
TI  - Propofol Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats.
PG  - 538-45
LID - 10.1007/s12031-015-0634-2 [doi]
AB  - Our previous studies demonstrated that propofol protects rat brain against focal 
      cerebral ischemia. However, whether propofol attenuates early brain injury after 
      subarachnoid hemorrhage in rats remains unknown until now. The present study was 
      performed to evaluate the effect of propofol on early brain injury after 
      subarachnoid hemorrhage in rats and further explore the potential mechanisms. 
      Sprague-Dawley rats underwent subarachnoid hemorrhage (SAH) by endovascular 
      perforation then received treatment with propofol (10 or 50 mg/kg) or vehicle 
      after 2 and 12 h of SAH. SAH grading, neurological scores, brain water content, 
      Evans blue extravasation, the myeloperoxidase activity, and malondialdehyde (MDA) 
      content were measured 24 h after SAH. Expression of nuclear factor 
      erythroid-related factor 2 (Nrf2), nuclear factor-kappa B (NF-kappaB) p65, and 
      aquaporin 4 (AQP4) expression in rat brain were detected by Western blot. 
      Expression of cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) 
      were determined by reverse transcription-polymerase chain reaction (RT-PCR). 
      Expressions of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were 
      assessed by ELISA. Neurological scores, brain water content, Evans blue 
      extravasation, the myeloperoxidase activity, and MDA content were significantly 
      reduced by propofol. Furthermore, expression of Nrf2 in rat brain was upregulated 
      by propofol, and expression of NF-kappaB p65, AQP4, COX-2, MMP-9, TNF-alpha, and IL-1beta in 
      rat brain were attenuated by propofol. Our results demonstrated that propofol 
      improves neurological scores, reduces brain edema, blood-brain barrier (BBB) 
      permeability, inflammatory reaction, and lipid peroxidation in rats of SAH. 
      Propofol exerts neuroprotection against SAH-induced early brain injury, which 
      might be associated with the inhibition of inflammation and lipid peroxidation.
FAU - Shi, Song-sheng
AU  - Shi SS
AD  - Department of Neurosurgery, The Affiliated Union Hospital of Fujian Medical 
      University, Neurosurgery Research Institute of Fujian Province, No. 29 Xinquan 
      Road, Fuzhou, Fujian, 350001, China.
FAU - Zhang, Hua-bin
AU  - Zhang HB
AD  - Department of Neurosurgery, The Affiliated Union Hospital of Fujian Medical 
      University, Neurosurgery Research Institute of Fujian Province, No. 29 Xinquan 
      Road, Fuzhou, Fujian, 350001, China.
FAU - Wang, Chun-hua
AU  - Wang CH
AD  - Department of Neurosurgery, The Affiliated Union Hospital of Fujian Medical 
      University, Neurosurgery Research Institute of Fujian Province, No. 29 Xinquan 
      Road, Fuzhou, Fujian, 350001, China.
FAU - Yang, Wei-zhong
AU  - Yang WZ
AD  - Department of Neurosurgery, The Affiliated Union Hospital of Fujian Medical 
      University, Neurosurgery Research Institute of Fujian Province, No. 29 Xinquan 
      Road, Fuzhou, Fujian, 350001, China.
FAU - Liang, Ri-sheng
AU  - Liang RS
AD  - Department of Neurosurgery, The Affiliated Union Hospital of Fujian Medical 
      University, Neurosurgery Research Institute of Fujian Province, No. 29 Xinquan 
      Road, Fuzhou, Fujian, 350001, China.
FAU - Chen, Ye
AU  - Chen Y
AD  - Department of Neurosurgery, The Affiliated Union Hospital of Fujian Medical 
      University, Neurosurgery Research Institute of Fujian Province, No. 29 Xinquan 
      Road, Fuzhou, Fujian, 350001, China.
FAU - Tu, Xian-kun
AU  - Tu XK
AD  - Department of Neurosurgery, The Affiliated Union Hospital of Fujian Medical 
      University, Neurosurgery Research Institute of Fujian Province, No. 29 Xinquan 
      Road, Fuzhou, Fujian, 350001, China. unionnstu@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150905
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Aqp4 protein, rat)
RN  - 0 (Aquaporin 4)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NF-kappa B)
RN  - 0 (Nfe2l2 protein, rat)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.35 (Mmp9 protein, rat)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Animals
MH  - Aquaporin 4/genetics/metabolism
MH  - Blood-Brain Barrier/drug effects/metabolism
MH  - Cyclooxygenase 2/genetics/metabolism
MH  - Interleukin-1beta/genetics/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 9/genetics/metabolism
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - NF-kappa B/genetics/metabolism
MH  - Propofol/pharmacology/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Subarachnoid Hemorrhage/*drug therapy/metabolism
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
OTO - NOTNLM
OT  - Cyclooxygenase-2
OT  - Inflammation
OT  - Matrix metalloproteinase-9
OT  - Nuclear factor erythroid-related factor 2
OT  - Nuclear factor-kappa B
OT  - Propofol
OT  - Subarachnoid hemorrhage
EDAT- 2015/09/08 06:00
MHDA- 2016/08/25 06:00
CRDT- 2015/09/07 06:00
PHST- 2015/06/10 00:00 [received]
PHST- 2015/07/28 00:00 [accepted]
PHST- 2015/09/07 06:00 [entrez]
PHST- 2015/09/08 06:00 [pubmed]
PHST- 2016/08/25 06:00 [medline]
AID - 10.1007/s12031-015-0634-2 [pii]
AID - 10.1007/s12031-015-0634-2 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2015 Dec;57(4):538-45. doi: 10.1007/s12031-015-0634-2. Epub 2015 
      Sep 5.