PMID- 26343077
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20221207
IS  - 2066-8643 (Electronic)
IS  - 1844-4172 (Linking)
VI  - 17
IP  - 3
DP  - 2015 Sep
TI  - Age, abdominal obesity, and glycated hemoglobin are associated with carotid 
      atherosclerosis in type 2 diabetes patients with nonalcoholic fatty liver 
      disease.
PG  - 300-7
LID - 10.11152/mu.2013.2066.173.cas [doi]
AB  - AIM: The aim of this study was to evaluate the impact of clinical parameters and 
      indices of body composition on the relation between non-alcoholic fatty liver 
      disease (NAFLD) and carotid intima-media thickness (cIMT), in a type 2 diabetes 
      mellitus population (T2DM). MATERIAL AND METHODS: We retrospectively enrolled 336 
      T2DM outpatients who regularly attended Regina Maria Clinic in Cluj. Clinical, 
      anthropometric and biochemical parameters were measured. Ultrasonography (US) was 
      used to assess hepatic steatosis (HS) in all patients and cIMT in 146 subjects. 
      Body composition was assessed by bioelectric impedance (BIA, InBody 720) in all 
      patients. RESULTS: cIMT was correlated with age (r=0.25; p=0.004), systolic blood 
      pressure (r=0.18; p=0.041), glycated haemoglobin A1C (HbA1C, r=0.20; p=0.04), and 
      with coronary artery disease (r=0.20; p=0.007). HS did not correlate with cIMT 
      (r=0.04; p=0.64). cIMT was correlated with visceral fatty area (VFA, r=0.18; 
      p=0.014) but not with other indices of body composition. Homeostasis model 
      assessment for insulin resistance (HOMA-IR) was not correlated with cIMT (r=0.17; 
      p=0.086). After multivariate analysis, age, HbA1c, and VFA were good independent 
      predictors of cIMT (r=0.45; p < 0.001). CONCLUSIONS: These results are suggestive 
      that in T2DM patients, fatty liver is not a direct mediator of early carotid 
      atherosclerosis. Our data indicate that visceral fat accumulation and HbA1C are 
      determinant factors of cIMT sugesting that controlling abdominal obesity and 
      hyperglicemia might reduce atherosclerotic disease risk in NAFLD-T2DM subjects.
FAU - Silaghi, Cristina Alina
AU  - Silaghi CA
AD  - Endocrinology Department, "Iuliu Hatieganu" University of Medicine and Pharmacy; 
      County Clinic Emergency Hospital, Cluj-Napoca, Romania.
FAU - Silaghi, Horatiu
AU  - Silaghi H
AD  - 5th Surgery Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 
      Cluj-Napoca, Romania. hsilaghi@yahoo.com.
FAU - Craciun, Anca Elena
AU  - Craciun AE
AD  - Diabet, Nutrition and Metabolic Diseases Department, "Iuliu Hatieganu" University 
      of Medicine and Pharmacy; Regina Maria Clinic, Cluj-Napoca, Romania.
FAU - Farcas, Anca
AU  - Farcas A
AD  - Regina Maria Clinic, Cluj-Napoca; 1st Internal Medicine Department, "Iuliu 
      Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
FAU - Colosi, Horatiu Alexandru
AU  - Colosi HA
AD  - Medical Informatics and Biostatistics Department, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, Cluj-Napoca, Romania.
FAU - Cosma, Daniel Tudor
AU  - Cosma DT
AD  - County Clinic Emergency Hospital, Cluj-Napoca; Diabet, Nutrition and Metabolic 
      Diseases Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 
      Cluj-Napoca, Romania.
FAU - Pais, Raluca
AU  - Pais R
AD  - Service Hepatogastroenterologie, Hopital Pitie- Salpetriere, Universite Pierre et 
      Marie Curie, INSERM UMRS 938, Paris, France.
FAU - Hancu, Nicolae
AU  - Hancu N
AD  - Regina Maria Clinic, Cluj-Napoca, Romania.
FAU - Georgescu, Carmen Emanuela
AU  - Georgescu CE
AD  - Endocrinology Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 
      Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Med Ultrason
JT  - Medical ultrasonography
JID - 101522985
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Age Factors
MH  - Body Composition
MH  - Carotid Artery Diseases/*diagnostic imaging/*etiology
MH  - Carotid Intima-Media Thickness
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Electric Impedance
MH  - Fatty Liver/*complications/*diagnostic imaging
MH  - Female
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/*complications
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2015/09/08 06:00
MHDA- 2016/06/18 06:00
CRDT- 2015/09/08 06:00
PHST- 2015/09/08 06:00 [entrez]
PHST- 2015/09/08 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
AID - 10.11152/mu.2013.2066.173.cas [doi]
PST - ppublish
SO  - Med Ultrason. 2015 Sep;17(3):300-7. doi: 10.11152/mu.2013.2066.173.cas.