PMID- 26343231
OWN - NLM
STAT- MEDLINE
DCOM- 20151229
LR  - 20150929
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 116
IP  - 8
DP  - 2015 Oct 15
TI  - Left Ventricular Strain and Myocardial Fibrosis in Congenital Aortic Stenosis.
PG  - 1257-62
LID - S0002-9149(15)01702-6 [pii]
LID - 10.1016/j.amjcard.2015.07.042 [doi]
AB  - The aim of this study was to evaluate whether left ventricular (LV) systolic 
      strain in children and young adults with congenital aortic stenosis (AS) and 
      preserved ejection fraction was different from normal subjects and to determine 
      whether any alterations in strain were related to myocardial fibrosis. In this 
      retrospective study, 29 patients with congenital AS with a median age of 
      15.3 years (range 1.7 to 23.7), highest lifetime AS peak Doppler gradient of 
      73 mm Hg (22 to 110), most recent AS peak Doppler gradient of 49 mm Hg (0 to 90), 
      and ejection fraction of 65 (55 to 79) were included. Strain was measured using 
      2-dimensional speckle-tracking echocardiography. Cardiac magnetic resonance was 
      used to identify focal fibrosis by late gadolinium enhancement (LGE) and diffuse 
      fibrosis by calculating the extracellular volume fraction (ECV) from T1 
      measurements. Compared to age-matched controls (n = 29), patients with AS had 
      reduced LV longitudinal (17.0 +/- 3.0% vs 20.6 +/- 2.2%, p <0.001) and radial strain 
      (28.8 +/- 8.6% vs 34.9 +/- 8.5%, p = 0.01), and similar circumferential strain (26.2 
      +/- 5.9% vs 26.4 +/- 3.9%, p = 0.79). Median ECV in patients with AS was 0.27 (0.22 
      to 0.38) and was not significantly correlated with systolic strain. Patients with 
      LGE (n = 7) had lower longitudinal strain than those without LGE (n = 21; 15.0 +/- 
      2.2 vs 17.7 +/- 3.1, p = 0.036). In conclusion, in this cohort of children and 
      young adults with congenital AS and preserved ejection fraction, longitudinal and 
      radial strain were reduced, and decreased longitudinal strain was associated with 
      LGE but not ECV.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Dusenbery, Susan M
AU  - Dusenbery SM
AD  - Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; 
      Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. 
      Electronic address: susan.dusenbery@cardio.chboston.org.
FAU - Lunze, Fatima I
AU  - Lunze FI
AD  - Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; 
      Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
FAU - Jerosch-Herold, Michael
AU  - Jerosch-Herold M
AD  - Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts; 
      Department of Radiology, Harvard Medical School, Boston, Massachusetts.
FAU - Geva, Tal
AU  - Geva T
AD  - Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; 
      Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
FAU - Newburger, Jane W
AU  - Newburger JW
AD  - Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; 
      Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
FAU - Colan, Steven D
AU  - Colan SD
AD  - Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; 
      Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
FAU - Powell, Andrew J
AU  - Powell AJ
AD  - Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; 
      Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
LA  - eng
PT  - Clinical Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150728
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Adolescent
MH  - Aortic Valve Stenosis/*complications/diagnosis/*physiopathology
MH  - Cardiomyopathies/complications/diagnosis/*physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Elasticity/physiology
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Infant
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Retrospective Studies
MH  - Stroke Volume/physiology
MH  - Systole/physiology
MH  - Ventricular Dysfunction, Left/complications/diagnosis/*physiopathology
MH  - Young Adult
EDAT- 2015/09/08 06:00
MHDA- 2015/12/30 06:00
CRDT- 2015/09/08 06:00
PHST- 2015/04/28 00:00 [received]
PHST- 2015/07/16 00:00 [revised]
PHST- 2015/07/16 00:00 [accepted]
PHST- 2015/09/08 06:00 [entrez]
PHST- 2015/09/08 06:00 [pubmed]
PHST- 2015/12/30 06:00 [medline]
AID - S0002-9149(15)01702-6 [pii]
AID - 10.1016/j.amjcard.2015.07.042 [doi]
PST - ppublish
SO  - Am J Cardiol. 2015 Oct 15;116(8):1257-62. doi: 10.1016/j.amjcard.2015.07.042. 
      Epub 2015 Jul 28.