PMID- 26343470
OWN - NLM
STAT- MEDLINE
DCOM- 20160425
LR  - 20181202
IS  - 1532-8384 (Electronic)
IS  - 0010-440X (Linking)
VI  - 62
DP  - 2015 Oct
TI  - Serum brain-derived neurotrophic factor levels and psychotic symptoms in heroin 
      dependence.
PG  - 80-5
LID - S0010-440X(15)00099-1 [pii]
LID - 10.1016/j.comppsych.2015.06.008 [doi]
AB  - OBJECTIVES: Psychotic symptoms are commonly observed among heroin users. Low 
      serum brain-derived neurotrophic factor (BDNF) levels have been reported in 
      schizophrenia and psychosis; however, studies assessing the relationship between 
      serum BDNF levels and psychotic symptoms in heroin dependence are lacking. 
      METHOD: A total of 31 heroin-dependent patients who had never experienced 
      psychotic symptoms during heroin consumption and 21 patients with a history of 
      psychotic symptoms were consecutively recruited. We measured by enzyme-linked 
      immunosorbent assay (ELISA) serum BDNF levels during early abstinence. A gender- 
      and age-matched sample of healthy controls was also recruited and underwent 
      measurement of BDNF. RESULTS: BDNF levels were significantly lower in patients 
      with psychotic symptoms than in those without psychotic symptoms (P<0.001). BDNF 
      levels were not found to be correlated with sex, age, age of onset, duration of 
      heroin use, average daily dose of heroin use, frequency of heroin use, SDS 
      scores, BAI scores and BDI scores in the psychotic subsamples (all P>0.05). 
      CONCLUSIONS: Our findings suggest that heroin-dependent patients with psychotic 
      symptoms share some of the neurotrophic insult that characterizes schizophrenia 
      and psychosis.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Han, B
AU  - Han B
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Zhang, X Y
AU  - Zhang XY
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, BJ 100096, PR China; 
      Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of 
      Medicine, Houston, TX 77030, USA.
FAU - Wang, D Y
AU  - Wang DY
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China; Department of Psychiatry, 
      People's Hospital of Yueqing, Wenzhou, 325600, China.
FAU - Ren, W W
AU  - Ren WW
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Gu, Y Y
AU  - Gu YY
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Zhu, L
AU  - Zhu L
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Chang, Y L
AU  - Chang YL
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Wang, L P
AU  - Wang LP
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Wu, C W
AU  - Wu CW
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Jin, Q Q
AU  - Jin QQ
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Chen, C
AU  - Chen C
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Lyu, D Z
AU  - Lyu DZ
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Zhao, J Y
AU  - Zhao JY
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - Shao, B
AU  - Shao B
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China.
FAU - He, J C
AU  - He JC
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang Province, China. Electronic address: 
      hjc@wmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150611
PL  - United States
TA  - Compr Psychiatry
JT  - Comprehensive psychiatry
JID - 0372612
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Heroin Dependence/*blood/complications/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychotic Disorders/*blood/*complications/psychology
EDAT- 2015/09/08 06:00
MHDA- 2016/04/26 06:00
CRDT- 2015/09/08 06:00
PHST- 2015/04/01 00:00 [received]
PHST- 2015/06/06 00:00 [accepted]
PHST- 2015/09/08 06:00 [entrez]
PHST- 2015/09/08 06:00 [pubmed]
PHST- 2016/04/26 06:00 [medline]
AID - S0010-440X(15)00099-1 [pii]
AID - 10.1016/j.comppsych.2015.06.008 [doi]
PST - ppublish
SO  - Compr Psychiatry. 2015 Oct;62:80-5. doi: 10.1016/j.comppsych.2015.06.008. Epub 
      2015 Jun 11.