PMID- 26343686
OWN - NLM
STAT- MEDLINE
DCOM- 20160607
LR  - 20181113
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 13
IP  - 9
DP  - 2015 Aug 26
TI  - Interaction between Marine-Derived n-3 Long Chain Polyunsaturated Fatty Acids and 
      Uric Acid on Glucose Metabolism and Risk of Type 2 Diabetes Mellitus: A 
      Case-Control Study.
PG  - 5564-78
LID - 10.3390/md13095564 [doi]
AB  - The present case-control study explored the interaction between marine-derived 
      n-3 long chain polyunsaturated fatty acids (n-3 LC PUFAs) and uric acid (UA) on 
      glucose metabolism and risk of type 2 diabetes mellitus (T2DM). Two hundred and 
      eleven healthy subjects in control group and 268 T2DM subjects in case group were 
      included. Plasma phospholipid (PL) fatty acids and biochemical parameters were 
      detected by standard methods. Plasma PL C22:6n-3 was significantly lower in case 
      group than in control group, and was negatively correlated with fasting glucose 
      (r = -0.177, p < 0.001). Higher plasma PL C22:6n-3 was associated with lower risk 
      of T2DM, and the OR was 0.32 (95% confidence interval (CI), 0.12 to 0.80; p = 
      0.016) for per unit increase of C22:6n-3. UA was significantly lower in case 
      group than in control group. UA was positively correlated with fasting glucose in 
      healthy subjects, but this correlation became negative in T2DM subjects. A 
      significant interaction was observed between C22:6n-3 and UA on fasting glucose 
      (p for interaction = 0.005): the lowering effect of C22:6n-3 was only significant 
      in subjects with a lower level of UA. In conclusion, C22:6n-3 interacts with UA 
      to modulate glucose metabolism.
FAU - Li, Kelei
AU  - Li K
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, 
      China. wfujfqcc@sina.com.
FAU - Wu, Kejian
AU  - Wu K
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, 
      China. wkj016b@163.com.
FAU - Zhao, Yimin
AU  - Zhao Y
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, 
      China. davidzhao2147@gmail.com.
FAU - Huang, Tao
AU  - Huang T
AD  - Department of Nutrition and Epidemiology, Harvard School of Public Health, 
      Boston, MA 02115, USA. taohuang83@gmail.com.
FAU - Lou, Dajun
AU  - Lou D
AD  - Department of Endocrinology, Shaoxing Hospital, Shaoxing 312000, China. 
      loudajun@sina.com.
FAU - Yu, Xiaomei
AU  - Yu X
AD  - Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310013, China. 
      yuxiaomei_1@hotmail.com.
FAU - Li, Duo
AU  - Li D
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, 
      China. duoli@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150826
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 268B43MJ25 (Uric Acid)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Aquatic Organisms
MH  - Blood Glucose
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Fatty Acids, Omega-3/*blood
MH  - Female
MH  - Glucose/*metabolism
MH  - Humans
MH  - Lipid Metabolism
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Uric Acid/*blood
PMC - PMC4584340
OTO - NOTNLM
OT  - human
OT  - n-3 polyunsaturated fatty acids
OT  - type 2 diabetes
OT  - uric acid
EDAT- 2015/09/08 06:00
MHDA- 2016/06/09 06:00
PMCR- 2015/09/01
CRDT- 2015/09/08 06:00
PHST- 2015/05/28 00:00 [received]
PHST- 2015/07/22 00:00 [revised]
PHST- 2015/08/06 00:00 [accepted]
PHST- 2015/09/08 06:00 [entrez]
PHST- 2015/09/08 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - md13095564 [pii]
AID - marinedrugs-13-05564 [pii]
AID - 10.3390/md13095564 [doi]
PST - epublish
SO  - Mar Drugs. 2015 Aug 26;13(9):5564-78. doi: 10.3390/md13095564.