PMID- 26344727
OWN - NLM
STAT- MEDLINE
DCOM- 20170322
LR  - 20220310
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 254
IP  - 5
DP  - 2016 May
TI  - Functional and high-resolution retinal imaging monitoring photoreceptor damage in 
      acute macular neuroretinopathy.
PG  - 855-64
LID - 10.1007/s00417-015-3136-6 [doi]
AB  - BACKGROUND: To report functional and high-resolution retinal imaging 
      abnormalities, including adaptive optics (AO) throughout the course of acute 
      macular neuroretinopathy (AMNR). METHODS: Two female patients (four eyes) with a 
      diagnosis of AMNR were observed at the Clinical Investigation Center, CHNO des 
      Quinze-Vingts, Paris, France. The patients underwent detailed ophthalmic 
      examination including best-corrected visual acuity, slit-lamp examination, 
      kinetic and static perimetry, full-field and multifocal electroretinogram, 
      infrared reflectance, autofluorescence imaging and spectral-domain optical 
      coherence tomography (SD-OCT) and AO fundus imaging at presentation and during 
      follow-up. RESULTS: Both cases showed concomitant loss of integrity of the outer 
      retinal structures on SD-OCT, and marked abnormalities on AO imaging with 
      disruption of the visibility of the cone mosaic. In the first case, photoreceptor 
      damage was seen to progress during several weeks before healing. In both cases, 
      there were persistent morphological abnormalities of photoreceptors 1 year after 
      onset. CONCLUSION: This study further highlights the value of AO fundus imaging 
      to facilitate detection, mapping, and monitoring of damage to the cone outer 
      segments during AMNR. In particular, residual damage to the cone mosaic can be 
      precisely documented.
FAU - Audo, Isabelle
AU  - Audo I
AD  - Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, 
      INSERM-DHOS CIC 1423, Paris, 75012, France. isabelle.audo@inserm.fr.
AD  - INSERM, U968, Paris, 75012, France. isabelle.audo@inserm.fr.
AD  - Institut de la Vision, Sorbonne Universites, UPMC Univ Paris 06, UMR_S 968, 
      Paris, 75012, France. isabelle.audo@inserm.fr.
AD  - CNRS, UMR_7210, Paris, 75012, France. isabelle.audo@inserm.fr.
AD  - Departement de Genetique, Curie/CHNO des Quinze-Vingts, Centre de Recherche 
      Institut de la Vision, UMR S 968 Inserm / Universite Pierre et Marie, 17, rue 
      Moreau, 75012, Paris, France. isabelle.audo@inserm.fr.
FAU - Gocho, Kiyoko
AU  - Gocho K
AD  - Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, 
      INSERM-DHOS CIC 1423, Paris, 75012, France.
AD  - Ophthalmology, Nippon Medical University, Chiba Hokusoh Hospital, Inzai, Japan.
FAU - Rossant, Florence
AU  - Rossant F
AD  - Institut Superieur d'Electronique de Paris, Paris, France.
FAU - Mohand-Said, Saddek
AU  - Mohand-Said S
AD  - Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, 
      INSERM-DHOS CIC 1423, Paris, 75012, France.
AD  - INSERM, U968, Paris, 75012, France.
AD  - Institut de la Vision, Sorbonne Universites, UPMC Univ Paris 06, UMR_S 968, 
      Paris, 75012, France.
AD  - CNRS, UMR_7210, Paris, 75012, France.
FAU - Loquin, Kevin
AU  - Loquin K
AD  - Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
FAU - Bloch, Isabelle
AU  - Bloch I
AD  - Telecom Paris Tech, CNRS LTCI, Paris, France.
FAU - Sahel, Jose-Alain
AU  - Sahel JA
AD  - Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, 
      INSERM-DHOS CIC 1423, Paris, 75012, France.
AD  - INSERM, U968, Paris, 75012, France.
AD  - Institut de la Vision, Sorbonne Universites, UPMC Univ Paris 06, UMR_S 968, 
      Paris, 75012, France.
AD  - CNRS, UMR_7210, Paris, 75012, France.
AD  - Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
AD  - Academie des Sciences-Institut de France, Paris, 75006, France.
FAU - Paques, Michel
AU  - Paques M
AD  - Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU View Maintain, 
      INSERM-DHOS CIC 1423, Paris, 75012, France.
AD  - INSERM, U968, Paris, 75012, France.
AD  - Institut de la Vision, Sorbonne Universites, UPMC Univ Paris 06, UMR_S 968, 
      Paris, 75012, France.
AD  - CNRS, UMR_7210, Paris, 75012, France.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150907
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Diagnostic Imaging
MH  - Electroretinography
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Retinal Diseases/*diagnostic imaging/*physiopathology
MH  - Scotoma/physiopathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Acute macular neuroretinopathy
OT  - Adaptive optics
OT  - High-resolution retinal imaging
OT  - Multimodal retinal imaging
OT  - SD-OCT
EDAT- 2015/09/08 06:00
MHDA- 2017/03/23 06:00
CRDT- 2015/09/08 06:00
PHST- 2015/04/20 00:00 [received]
PHST- 2015/08/10 00:00 [accepted]
PHST- 2015/07/30 00:00 [revised]
PHST- 2015/09/08 06:00 [entrez]
PHST- 2015/09/08 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
AID - 10.1007/s00417-015-3136-6 [pii]
AID - 10.1007/s00417-015-3136-6 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2016 May;254(5):855-64. doi: 
      10.1007/s00417-015-3136-6. Epub 2015 Sep 7.