PMID- 26345405
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1557-9891 (Electronic)
IS  - 1557-9883 (Print)
IS  - 1557-9883 (Linking)
VI  - 11
IP  - 1
DP  - 2017 Jan
TI  - Steroid Hormone Receptors as Potential Mediators of the Clinical Effects of 
      Dutasteride: A Prospective, Randomized, Double-Blind Study.
PG  - 126-133
LID - 10.1177/1557988315602961 [doi]
AB  - This study characterizes the clinical and morphofunctional effects of a 
      5alpha-reductase inhibitor on steroid hormone receptors in normal human prostate 
      tissue, as potential mediators of the clinical effects of dutasteride. This work 
      was a prospective, double-blind, and randomized study that evaluated 49 men aged 
      between 45 and 70 years, with no alterations in a digital rectal examination and 
      prostate-specific antigen measurements between 2.5 and 4.0 ng/mL. These patients 
      underwent prostate biopsy guided by transretal ultrasound with prostate neoplasia 
      being ruled out, and the patients were divided into two groups, with one group 
      receiving dutasteride ( n = 25) and one group receiving a placebo ( n = 24). The 
      patients were clinically assessed each quarter, and at the end of 12 months they 
      underwent new laboratory tests, prostate rebiopsy, and histopathological, 
      immunohistochemical and clinical analyses. The estrogen receptor-beta (ERbeta) and 
      androgen receptor immunoreactivities were higher, and the proliferation/apoptotic 
      ratio was significantly lower with predominance of the apoptotic process, 
      followed by a significant reduction in the prostate volume and the total serum 
      prostate-specific antigen levels in the dutasteride group when compared with the 
      placebo group, with a clear supremacy of ERbeta. There were no significant 
      variations in the serum estrogen and testosterone levels, in the body mass index, 
      or in the ERalpha immunoreactivities in the dutasteride and placebo groups. The 
      results demonstrated the importance of the ERbeta pathway in the activation 
      mechanisms of apoptosis, exerting a protective effect in the normal prostate, 
      indicating that this receptor might be an important mediator of the clinical 
      effects of dutasteride.
FAU - Alonso, Joao C C
AU  - Alonso JCC
AD  - 1 University of Campinas, Campinas, Sao Paulo, Brazil.
AD  - 2 Municipal Hospital of Paulinia, Paulinia, Sao Paulo, Brazil.
FAU - Reis, Leonardo O
AU  - Reis LO
AD  - 1 University of Campinas, Campinas, Sao Paulo, Brazil.
AD  - 2 Municipal Hospital of Paulinia, Paulinia, Sao Paulo, Brazil.
AD  - 3 Pontifical Catholic University of Campinas, Campinas, Sao Paulo, Brazil.
FAU - Garcia, Patrick V
AU  - Garcia PV
AD  - 1 University of Campinas, Campinas, Sao Paulo, Brazil.
FAU - Ferreira, Ubirajara
AU  - Ferreira U
AD  - 1 University of Campinas, Campinas, Sao Paulo, Brazil.
FAU - Matheus, Wagner E
AU  - Matheus WE
AD  - 1 University of Campinas, Campinas, Sao Paulo, Brazil.
FAU - Simoes, Fabiano A
AU  - Simoes FA
AD  - 2 Municipal Hospital of Paulinia, Paulinia, Sao Paulo, Brazil.
FAU - Rejowski, Ronald F
AU  - Rejowski RF
AD  - 2 Municipal Hospital of Paulinia, Paulinia, Sao Paulo, Brazil.
FAU - Alonso-Vale, Maria Isabel C
AU  - Alonso-Vale MIC
AD  - 4 Federal University of Sao Paulo, Diadema, Sao Paulo, Brazil.
FAU - Favaro, Wagner J
AU  - Favaro WJ
AD  - 1 University of Campinas, Campinas, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160708
PL  - United States
TA  - Am J Mens Health
JT  - American journal of men's health
JID - 101287723
PMC - PMC5675179
OTO - NOTNLM
OT  - 5alpha-reductase inhibitors
OT  - androgen receptor
OT  - dutasteride
OT  - estrogen receptor
OT  - prostate
OT  - steroid sex hormones
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2015/09/09 06:00
MHDA- 2015/09/09 06:01
PMCR- 2017/01/01
CRDT- 2015/09/09 06:00
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2015/09/09 06:01 [medline]
PHST- 2015/09/09 06:00 [entrez]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 1557988315602961 [pii]
AID - 10.1177_1557988315602961 [pii]
AID - 10.1177/1557988315602961 [doi]
PST - ppublish
SO  - Am J Mens Health. 2017 Jan;11(1):126-133. doi: 10.1177/1557988315602961. Epub 
      2016 Jul 8.